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• W1990976327 abstract "Abstract Epileptiform activity (EA) in vivo and in vitro induces a loss of dendritic spines and synapses. Because CaMKII has been implicated in synaptogenesis and synaptic plasticity, we investigated the role of CaMKII in the effects of EA on spines, using rat hippocampal slice cultures. To visualize dendrites and postsynaptic densities (PSDs) in pyramidal neurons in the slices, we used biolistic transfection to express either free GFP or a PSD95‐YFP construct that specifically labels PSDs. This allowed us to distinguish two classes of dendritic protrusions: spines that contain PSDs, and filopodia that lack PSDs and that are, on average, longer than spines. By these criteria, 48 hr of EA caused a decrease specifically in the number of spines. Immunoblots showed that EA increased CaMKII activity in the slices. Inhibition of CaMKII by expression of AIP, a specific peptide inhibitor of CaMKII, reduced spine number under basal conditions and failed to prevent EA‐induced spine loss. However, under EA conditions, AIP increased the number of filopodia and the number of PSDs on the dendritic shaft. These data show at least two roles for CaMKII activity in maintenance and remodeling of dendritic spines under basal or EA conditions. First, CaMKII activity promotes the maintenance of spines and spine PSDs. Second, CaMKII activity suppresses EA‐induced formation of filopodia and suppresses an increase in shaft PSDs, apparently by promoting translocation of PSDs from dendritic shafts to spines and/or selectively stabilizing spine rather than shaft PSDs. © 2009 Wiley‐Liss, Inc." @default.
• W1990976327 created "2016-06-24" @default.
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• W1990976327 date "2009-02-23" @default.
• W1990976327 modified "2023-10-18" @default.
• W1990976327 title "Role of Ca²⁺/calmodulin-dependent protein kinase II in dendritic spine remodeling during epileptiform activity in vitro" @default.
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• W1990976327 doi "https://doi.org/10.1002/jnr.22033" @default.
• W1990976327 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2694514" @default.
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