FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990976447> ?p ?o ?g. }

• W1990976447 endingPage "2433" @default.
• W1990976447 startingPage "2433" @default.
• W1990976447 abstract "purpose. A great deal of information about functionally significant domains of a protein may be obtained by comparison of primary sequences of gene homologues over a broad phylogenetic base. This study was designed to identify evolutionarily conserved domains of the photoreceptor disc membrane protein peripherin/rds by analysis of the homologue in a primitive vertebrate, the skate. methods. A skate retinal cDNA library was screened using a mouse peripherin/rds clone. The 5′ and 3′ untranslated regions of the skate peripherin/rds (srds) cDNA were isolated by the rapid amplification of cDNA ends (RACE) approach. The gene structure was characterized by PCR amplification and sequencing of genomic fragments. Northern and Western blot analyses were used to identify srds transcript and protein, respectively. results. A new homologue of peripherin/rds was identified from the skate retinal cDNA library. SRDS is a glycoprotein with a predicted molecular mass of 40.2 kDa. The srds gene consists of two exons and one small intron and transcribes into a single 6-kb message. Phylogenetic analysis places SRDS at the base of peripherin/rds family and near the division of that group and the branch leading to rds-like and rom-1 genes. SRDS protein is 54.5% identical with peripherin/rds across species. Identity is significantly higher (73%) in the intradiscal domains. Sequence comparison revealed the conservation of all residues that have been shown, on mutation, to associate with retinitis pigmentosa and showed conservation of most residues associated with macular dystrophies. Comparison with ROM-1 and other rds-like proteins revealed the presence of a highly conserved domain in the large intradiscal loop. conclusions. Srds represents the skate orthologue of mammalian peripherin/rds genes. Conservation of most of the residues associated with human retinal diseases indicates that these residues serve important functional roles. The high degree of conservation of a short stretch within the large intradiscal loop also suggests an important function for this domain." @default.
• W1990976447 created "2016-06-24" @default.
• W1990976447 creator A5018321686 @default.
• W1990976447 creator A5031536121 @default.
• W1990976447 creator A5052219361 @default.
• W1990976447 creator A5064044258 @default.
• W1990976447 creator A5067870745 @default.
• W1990976447 date "2003-06-01" @default.
• W1990976447 modified "2023-10-18" @default.
• W1990976447 title "Molecular Characterization of the Skate Peripherin/<i>rds</i>Gene: Relationship to Its Orthologues and Paralogues" @default.
• W1990976447 cites W1501393883 @default.
• W1990976447 cites W1544329852 @default.
• W1990976447 cites W1546639740 @default.
• W1990976447 cites W1554102421 @default.
• W1990976447 cites W1556616160 @default.
• W1990976447 cites W1568107853 @default.
• W1990976447 cites W1584230006 @default.
• W1990976447 cites W1964883218 @default.
• W1990976447 cites W1965046479 @default.
• W1990976447 cites W1966206620 @default.
• W1990976447 cites W1966297372 @default.
• W1990976447 cites W1966548998 @default.
• W1990976447 cites W1967370350 @default.
• W1990976447 cites W1985194979 @default.
• W1990976447 cites W1985693274 @default.
• W1990976447 cites W1995776276 @default.
• W1990976447 cites W1999719477 @default.
• W1990976447 cites W2000232627 @default.
• W1990976447 cites W2003442477 @default.
• W1990976447 cites W2014043220 @default.
• W1990976447 cites W2016490303 @default.
• W1990976447 cites W2016552180 @default.
• W1990976447 cites W2029944729 @default.
• W1990976447 cites W2030966943 @default.
• W1990976447 cites W2038489526 @default.
• W1990976447 cites W2055691766 @default.
• W1990976447 cites W2055989493 @default.
• W1990976447 cites W2061511003 @default.
• W1990976447 cites W2064722091 @default.
• W1990976447 cites W2066780072 @default.
• W1990976447 cites W2077136636 @default.
• W1990976447 cites W2078881388 @default.
• W1990976447 cites W2080904282 @default.
• W1990976447 cites W2086470900 @default.
• W1990976447 cites W2088449181 @default.
• W1990976447 cites W2094117679 @default.
• W1990976447 cites W2100837269 @default.
• W1990976447 cites W2108388593 @default.
• W1990976447 cites W2110829301 @default.
• W1990976447 cites W2127210883 @default.
• W1990976447 cites W2137214612 @default.
• W1990976447 cites W2144634347 @default.
• W1990976447 cites W2145756842 @default.
• W1990976447 cites W2166340108 @default.
• W1990976447 cites W218200083 @default.
• W1990976447 cites W2189068326 @default.
• W1990976447 cites W2253267274 @default.
• W1990976447 cites W2473154429 @default.
• W1990976447 cites W2601913882 @default.
• W1990976447 cites W3199943451 @default.
• W1990976447 doi "https://doi.org/10.1167/iovs.02-1152" @default.
• W1990976447 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2991160" @default.
• W1990976447 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12766040" @default.
• W1990976447 hasPublicationYear "2003" @default.
• W1990976447 type Work @default.
• W1990976447 sameAs 1990976447 @default.
• W1990976447 citedByCount "13" @default.
• W1990976447 countsByYear W19909764472018 @default.
• W1990976447 countsByYear W19909764472023 @default.
• W1990976447 crossrefType "journal-article" @default.
• W1990976447 hasAuthorship W1990976447A5018321686 @default.
• W1990976447 hasAuthorship W1990976447A5031536121 @default.
• W1990976447 hasAuthorship W1990976447A5052219361 @default.
• W1990976447 hasAuthorship W1990976447A5064044258 @default.
• W1990976447 hasAuthorship W1990976447A5067870745 @default.
• W1990976447 hasBestOaLocation W19909764472 @default.
• W1990976447 hasConcept C104317684 @default.
• W1990976447 hasConcept C187882448 @default.
• W1990976447 hasConcept C28521208 @default.
• W1990976447 hasConcept C36823959 @default.
• W1990976447 hasConcept C54355233 @default.
• W1990976447 hasConcept C86803240 @default.
• W1990976447 hasConcept C94671646 @default.
• W1990976447 hasConceptScore W1990976447C104317684 @default.
• W1990976447 hasConceptScore W1990976447C187882448 @default.
• W1990976447 hasConceptScore W1990976447C28521208 @default.
• W1990976447 hasConceptScore W1990976447C36823959 @default.
• W1990976447 hasConceptScore W1990976447C54355233 @default.
• W1990976447 hasConceptScore W1990976447C86803240 @default.
• W1990976447 hasConceptScore W1990976447C94671646 @default.
• W1990976447 hasIssue "6" @default.
• W1990976447 hasLocation W19909764471 @default.
• W1990976447 hasLocation W19909764472 @default.
• W1990976447 hasLocation W19909764473 @default.
• W1990976447 hasOpenAccess W1990976447 @default.
• W1990976447 hasPrimaryLocation W19909764471 @default.
• W1990976447 hasRelatedWork W1967095384 @default.
• W1990976447 hasRelatedWork W1980617967 @default.

• next