FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990980958> ?p ?o ?g. }

• W1990980958 endingPage "2220" @default.
• W1990980958 startingPage "2210" @default.
• W1990980958 abstract "Elevated signs of anxiety are observed in both humans and rodents during withdrawal from chronic as well as acute ethanol exposure, and it represents an important motivational factor for ethanol relapse. Several reports have suggested the involvement of brain adenosine receptors in different actions produced by ethanol such as motor incoordination and hypnotic effects. In addition, we have recently demonstrated that adenosine A1 receptors modulate the anxiolytic-like effect induced by ethanol in mice. In the present study, we evaluated the potential of adenosine A1 and A2A receptor agonists in reducing the anxiety-like behavior during acute ethanol withdrawal (hangover) in mice. Animals received a single intraperitoneal administration of saline or ethanol (4 g/kg) and were tested in the elevated plus maze after an interval of 0.5–24 h. The results indicated that hangover-induced anxiety was most pronounced between 12 and 18 h after ethanol administration, as indicated by a significant reduction in the exploration of the open arms of the maze. At this time interval, ethanol was completely cleared. The acute administration of ‘nonanxiolytic’ doses of adenosine and the selective adenosine A1 receptor agonist 2-chloro-N6-cyclopentyladenosine (CCPA), but not the adenosine A2A receptor agonist N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl]adenosine (DPMA), at the onset of peak withdrawal (18 h), reduced this anxiogenic-like response. In addition, the effect of CCPA on the anxiety-like behavior of ethanol hangover was reversed by pretreatment with the selective adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX). These results reinforce the notion of the involvement of adenosine receptors in the anxiety-like responses and indicate the potential of adenosine A1 receptor agonists to reduce the anxiogenic effects during ethanol withdrawal." @default.
• W1990980958 created "2016-06-24" @default.
• W1990980958 creator A5016272027 @default.
• W1990980958 creator A5025881418 @default.
• W1990980958 creator A5037947961 @default.
• W1990980958 creator A5061294250 @default.
• W1990980958 creator A5083646557 @default.
• W1990980958 date "2006-01-11" @default.
• W1990980958 modified "2023-10-17" @default.
• W1990980958 title "Activation of Adenosine A1 Receptors Reduces Anxiety-Like Behavior During Acute Ethanol Withdrawal (Hangover) in Mice" @default.
• W1990980958 cites W1490848194 @default.
• W1990980958 cites W1520157843 @default.
• W1990980958 cites W1521659744 @default.
• W1990980958 cites W1965051624 @default.
• W1990980958 cites W1968400267 @default.
• W1990980958 cites W1972204245 @default.
• W1990980958 cites W1982883582 @default.
• W1990980958 cites W1982888042 @default.
• W1990980958 cites W1984327929 @default.
• W1990980958 cites W1992860266 @default.
• W1990980958 cites W1995941325 @default.
• W1990980958 cites W1997696271 @default.
• W1990980958 cites W1997723786 @default.
• W1990980958 cites W1999470485 @default.
• W1990980958 cites W2005456011 @default.
• W1990980958 cites W2006076158 @default.
• W1990980958 cites W2009363746 @default.
• W1990980958 cites W2010392058 @default.
• W1990980958 cites W2012783828 @default.
• W1990980958 cites W2017436597 @default.
• W1990980958 cites W2017885112 @default.
• W1990980958 cites W2029733595 @default.
• W1990980958 cites W2034354321 @default.
• W1990980958 cites W2041561931 @default.
• W1990980958 cites W2043153453 @default.
• W1990980958 cites W2043961415 @default.
• W1990980958 cites W2044911631 @default.
• W1990980958 cites W2047130413 @default.
• W1990980958 cites W2053269045 @default.
• W1990980958 cites W2053566600 @default.
• W1990980958 cites W2055724397 @default.
• W1990980958 cites W2055768964 @default.
• W1990980958 cites W2060207467 @default.
• W1990980958 cites W2060985317 @default.
• W1990980958 cites W2066928707 @default.
• W1990980958 cites W2067438050 @default.
• W1990980958 cites W2067467266 @default.
• W1990980958 cites W2070572428 @default.
• W1990980958 cites W2079562583 @default.
• W1990980958 cites W2082369948 @default.
• W1990980958 cites W2083822913 @default.
• W1990980958 cites W2084275938 @default.
• W1990980958 cites W2087036957 @default.
• W1990980958 cites W2088133485 @default.
• W1990980958 cites W2093337711 @default.
• W1990980958 cites W2095679609 @default.
• W1990980958 cites W2106711665 @default.
• W1990980958 cites W2117715610 @default.
• W1990980958 cites W2138416809 @default.
• W1990980958 cites W2155090722 @default.
• W1990980958 cites W4230656139 @default.
• W1990980958 cites W4237131259 @default.
• W1990980958 cites W4239237742 @default.
• W1990980958 cites W53455726 @default.
• W1990980958 doi "https://doi.org/10.1038/sj.npp.1301001" @default.
• W1990980958 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16407902" @default.
• W1990980958 hasPublicationYear "2006" @default.
• W1990980958 type Work @default.
• W1990980958 sameAs 1990980958 @default.
• W1990980958 citedByCount "89" @default.
• W1990980958 countsByYear W19909809582012 @default.
• W1990980958 countsByYear W19909809582013 @default.
• W1990980958 countsByYear W19909809582014 @default.
• W1990980958 countsByYear W19909809582015 @default.
• W1990980958 countsByYear W19909809582016 @default.
• W1990980958 countsByYear W19909809582017 @default.
• W1990980958 countsByYear W19909809582018 @default.
• W1990980958 countsByYear W19909809582019 @default.
• W1990980958 countsByYear W19909809582020 @default.
• W1990980958 countsByYear W19909809582021 @default.
• W1990980958 countsByYear W19909809582022 @default.
• W1990980958 crossrefType "journal-article" @default.
• W1990980958 hasAuthorship W1990980958A5016272027 @default.
• W1990980958 hasAuthorship W1990980958A5025881418 @default.
• W1990980958 hasAuthorship W1990980958A5037947961 @default.
• W1990980958 hasAuthorship W1990980958A5061294250 @default.
• W1990980958 hasAuthorship W1990980958A5083646557 @default.
• W1990980958 hasBestOaLocation W19909809581 @default.
• W1990980958 hasConcept C118552586 @default.
• W1990980958 hasConcept C126322002 @default.
• W1990980958 hasConcept C134018914 @default.
• W1990980958 hasConcept C15744967 @default.
• W1990980958 hasConcept C170493617 @default.
• W1990980958 hasConcept C173586616 @default.
• W1990980958 hasConcept C182683403 @default.
• W1990980958 hasConcept C185592680 @default.
• W1990980958 hasConcept C205044023 @default.
• W1990980958 hasConcept C2776991684 @default.

• next