FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990985871> ?p ?o ?g. }

• W1990985871 endingPage "126" @default.
• W1990985871 startingPage "118" @default.
• W1990985871 abstract "Objective: CYR61 (cysteine-rich 61) belongs to the CCN (CYR61/CTGF/NOV) protein family and is involved in tumorigenesis. We have previously confirmed that the level of CYR61 protein is decreased in gastric carcinoma compared with nontumoral mucosa, by conducting proteome-based analyses. In this study, we examine the relationship between CYR61 expression and clinicopathological data of MMP-7 expression in human gastric mucosae and tumors. Methods: Immunohistochemical and/or immunofluorescence analyses were performed to examine the histological expression of CYR61 in normal gastric mucosa, intestinal metaplasia, 33 adenomas, and 127 carcinomas. Seven gastric carcinoma cell lines were used to examine the expression of CYR61 and MMP-7 by Western blotting. Results: The CYR61-expressing cells mostly coincided with the serotonin-containing cells, not only in nontumoral epithelia, but also among tumor cells. CYR61 expression was positive (labeling index: >2%) in 43 of 49 early gastric carcinomas (87.8%) and in 19 of 78 advanced gastric carcinomas (24.4%), the frequency being significantly lower in the latter (p < 0.001). All the normal mucosae, intestinal metaplasias and adenomas were in the positive group. The reduction in CYR61 expression correlated significantly with histological differentiation (p < 0.05), depth of invasion (p < 0.001), lymphatic invasion (p < 0.001), venous invasion (p < 0.001), lymph node metastasis (p < 0.001) and clinical stage (p < 0.001). Immunohistochemistry and Western blotting revealed the expression of CYR61 to be inversely correlated with that of MMP-7 (p < 0.001). Conclusions: CYR61 is expressed in serotonin-containing cells, and downregulation of the expression might contribute to the progression of cancer by promoting MMP-7 expression in human gastric carcinomas." @default.
• W1990985871 created "2016-06-24" @default.
• W1990985871 creator A5028784529 @default.
• W1990985871 creator A5033310099 @default.
• W1990985871 creator A5045633917 @default.
• W1990985871 creator A5047343907 @default.
• W1990985871 creator A5051104721 @default.
• W1990985871 creator A5086333336 @default.
• W1990985871 creator A5090384790 @default.
• W1990985871 date "2007-01-01" @default.
• W1990985871 modified "2023-09-25" @default.
• W1990985871 title "CYR61 Downregulation Correlates with Tumor Progression by Promoting MMP-7 Expression in Human Gastric Carcinoma" @default.
• W1990985871 cites W1521892157 @default.
• W1990985871 cites W1530583206 @default.
• W1990985871 cites W1574327030 @default.
• W1990985871 cites W1793987231 @default.
• W1990985871 cites W1886431664 @default.
• W1990985871 cites W1970409267 @default.
• W1990985871 cites W1980368281 @default.
• W1990985871 cites W1989012228 @default.
• W1990985871 cites W1999353913 @default.
• W1990985871 cites W2003500892 @default.
• W1990985871 cites W2004588239 @default.
• W1990985871 cites W2032912914 @default.
• W1990985871 cites W2035497705 @default.
• W1990985871 cites W2037477567 @default.
• W1990985871 cites W2049976919 @default.
• W1990985871 cites W2072114758 @default.
• W1990985871 cites W2077562220 @default.
• W1990985871 cites W2092315786 @default.
• W1990985871 cites W2104692426 @default.
• W1990985871 cites W2114752142 @default.
• W1990985871 cites W2130358475 @default.
• W1990985871 cites W2152110564 @default.
• W1990985871 cites W2158545941 @default.
• W1990985871 cites W2161702414 @default.
• W1990985871 cites W2166239763 @default.
• W1990985871 cites W2167292518 @default.
• W1990985871 cites W2169883682 @default.
• W1990985871 cites W2170963456 @default.
• W1990985871 cites W2322173990 @default.
• W1990985871 cites W2414023435 @default.
• W1990985871 cites W2938764154 @default.
• W1990985871 cites W2939515967 @default.
• W1990985871 cites W3146812933 @default.
• W1990985871 cites W4233611416 @default.
• W1990985871 cites W4247740511 @default.
• W1990985871 cites W4297119621 @default.
• W1990985871 doi "https://doi.org/10.1159/000121000" @default.
• W1990985871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18337624" @default.
• W1990985871 hasPublicationYear "2007" @default.
• W1990985871 type Work @default.
• W1990985871 sameAs 1990985871 @default.
• W1990985871 citedByCount "24" @default.
• W1990985871 countsByYear W19909858712012 @default.
• W1990985871 countsByYear W19909858712014 @default.
• W1990985871 countsByYear W19909858712015 @default.
• W1990985871 countsByYear W19909858712016 @default.
• W1990985871 countsByYear W19909858712017 @default.
• W1990985871 countsByYear W19909858712018 @default.
• W1990985871 countsByYear W19909858712021 @default.
• W1990985871 countsByYear W19909858712023 @default.
• W1990985871 crossrefType "journal-article" @default.
• W1990985871 hasAuthorship W1990985871A5028784529 @default.
• W1990985871 hasAuthorship W1990985871A5033310099 @default.
• W1990985871 hasAuthorship W1990985871A5045633917 @default.
• W1990985871 hasAuthorship W1990985871A5047343907 @default.
• W1990985871 hasAuthorship W1990985871A5051104721 @default.
• W1990985871 hasAuthorship W1990985871A5086333336 @default.
• W1990985871 hasAuthorship W1990985871A5090384790 @default.
• W1990985871 hasBestOaLocation W19909858712 @default.
• W1990985871 hasConcept C104317684 @default.
• W1990985871 hasConcept C121608353 @default.
• W1990985871 hasConcept C126322002 @default.
• W1990985871 hasConcept C127561419 @default.
• W1990985871 hasConcept C142724271 @default.
• W1990985871 hasConcept C170493617 @default.
• W1990985871 hasConcept C204232928 @default.
• W1990985871 hasConcept C2775960820 @default.
• W1990985871 hasConcept C2778753947 @default.
• W1990985871 hasConcept C2779013556 @default.
• W1990985871 hasConcept C2780631158 @default.
• W1990985871 hasConcept C502942594 @default.
• W1990985871 hasConcept C55493867 @default.
• W1990985871 hasConcept C555283112 @default.
• W1990985871 hasConcept C71924100 @default.
• W1990985871 hasConcept C86803240 @default.
• W1990985871 hasConceptScore W1990985871C104317684 @default.
• W1990985871 hasConceptScore W1990985871C121608353 @default.
• W1990985871 hasConceptScore W1990985871C126322002 @default.
• W1990985871 hasConceptScore W1990985871C127561419 @default.
• W1990985871 hasConceptScore W1990985871C142724271 @default.
• W1990985871 hasConceptScore W1990985871C170493617 @default.
• W1990985871 hasConceptScore W1990985871C204232928 @default.
• W1990985871 hasConceptScore W1990985871C2775960820 @default.
• W1990985871 hasConceptScore W1990985871C2778753947 @default.
• W1990985871 hasConceptScore W1990985871C2779013556 @default.
• W1990985871 hasConceptScore W1990985871C2780631158 @default.

• next