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- W1990988128 abstract "Neonatal primates have been reported to receive pig hearts without hyperacute rejection (HAR). We examined the ontogeny of the anti-pig xenoantibody (XenoAb) and HAR in the neonatal and infant monkeys.Twenty-six serum samples from 15 monkeys ages 14-192 days were subjected to hemagglutination titration against pig erythrocytes. Ten pig hearts were heterotopically transplanted into the monkeys.Six monkeys, ages 52-114 days, received pig hearts without HAR, and those ages 129-191 days hyperacutely rejected them. XenoAb titers were increased according to the age (Spearman's rank correlation value=0.909 (P<0.01)). XenoAb titers in 16 monkeys <4 months were significantly (P<0.01) lower than those in 10 monkeys >4 months.Anti-pig XenoAb titers increased with the age of the monkeys. XenoAb levels in monkeys >4 months are high enough to reject pig hearts hyperacutely." @default.
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- W1990988128 date "2000-08-01" @default.
- W1990988128 modified "2023-09-27" @default.
- W1990988128 title "ONTOGENY OF ANTIPIG XENOANTIBODY AND HYPERACUTE REJECTION1" @default.
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- W1990988128 doi "https://doi.org/10.1097/00007890-200008270-00025" @default.
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