Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990992912> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1990992912 endingPage "1884" @default.
- W1990992912 startingPage "1878" @default.
- W1990992912 abstract "Background —Endothelium-dependent dilator responses mediated by NO and endothelium-derived hyperpolarizing factor (EDHF) are altered in arteriosclerosis and sepsis. The possibility that proinflammatory mediators that stimulate the expression of inducible NO synthase (NOS II) affect the generation of EDHF was examined in isolated arteries. Methods and Results —Under combined blockade of NOS and cyclooxygenase, EDHF-mediated relaxation elicited by several agonists was significantly attenuated in rabbit carotid and porcine coronary arteries exposed to cytokines and lipopolysaccharide. The blunted relaxation was coincident with NOS II expression and was prevented by inhibition of NOS II as well as of global protein synthesis. The NO donor CAS 1609 and 8-bromo-cGMP mimicked the proinflammatory mediator effect. In contrast, long-term blockade of endothelial NO generation increased the relaxation in carotid but not in coronary arteries. Proinflammatory mediators reduced the synthesis of EDHF assessed as hyperpolarization of vascular smooth muscle cells elicited by the effluent from bradykinin-stimulated coronary arteries. Proinflammatory mediators induced NOS II expression in cultured endothelial cells and decreased the expression of cytochrome P450 enzymes, which are the most probable candidates for the synthesis of EDHF. Conclusions —Proinflammatory mediators inhibit the formation of EDHF in isolated arteries. This impairment is coincident with NOS II expression in the arterial wall and seems to be mediated through the induced generation of NO, which downregulates the putative EDHF-forming enzyme. Thus, a decreased formation of EDHF may contribute to the endothelial dysfunction in arteriosclerosis and sepsis." @default.
- W1990992912 created "2016-06-24" @default.
- W1990992912 creator A5000684986 @default.
- W1990992912 creator A5035811651 @default.
- W1990992912 creator A5050471583 @default.
- W1990992912 creator A5068617049 @default.
- W1990992912 date "1999-04-13" @default.
- W1990992912 modified "2023-10-17" @default.
- W1990992912 title "Proinflammatory Mediators Chronically Downregulate the Formation of the Endothelium-Derived Hyperpolarizing Factor in Arteries Via a Nitric Oxide/Cyclic GMP–Dependent Mechanism" @default.
- W1990992912 cites W1990251248 @default.
- W1990992912 cites W2020433268 @default.
- W1990992912 cites W2051048068 @default.
- W1990992912 cites W2058472159 @default.
- W1990992912 cites W2068057396 @default.
- W1990992912 cites W2076783344 @default.
- W1990992912 cites W2078964700 @default.
- W1990992912 cites W2092517767 @default.
- W1990992912 cites W2094470225 @default.
- W1990992912 cites W2139948472 @default.
- W1990992912 cites W4249419788 @default.
- W1990992912 doi "https://doi.org/10.1161/01.cir.99.14.1878" @default.
- W1990992912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10199886" @default.
- W1990992912 hasPublicationYear "1999" @default.
- W1990992912 type Work @default.
- W1990992912 sameAs 1990992912 @default.
- W1990992912 citedByCount "84" @default.
- W1990992912 countsByYear W19909929122012 @default.
- W1990992912 countsByYear W19909929122013 @default.
- W1990992912 countsByYear W19909929122014 @default.
- W1990992912 countsByYear W19909929122015 @default.
- W1990992912 countsByYear W19909929122016 @default.
- W1990992912 countsByYear W19909929122018 @default.
- W1990992912 countsByYear W19909929122019 @default.
- W1990992912 crossrefType "journal-article" @default.
- W1990992912 hasAuthorship W1990992912A5000684986 @default.
- W1990992912 hasAuthorship W1990992912A5035811651 @default.
- W1990992912 hasAuthorship W1990992912A5050471583 @default.
- W1990992912 hasAuthorship W1990992912A5068617049 @default.
- W1990992912 hasBestOaLocation W19909929121 @default.
- W1990992912 hasConcept C126322002 @default.
- W1990992912 hasConcept C134018914 @default.
- W1990992912 hasConcept C164027704 @default.
- W1990992912 hasConcept C170493617 @default.
- W1990992912 hasConcept C2776914184 @default.
- W1990992912 hasConcept C2776992346 @default.
- W1990992912 hasConcept C2777622882 @default.
- W1990992912 hasConcept C2778010969 @default.
- W1990992912 hasConcept C2779591629 @default.
- W1990992912 hasConcept C2780419564 @default.
- W1990992912 hasConcept C2780733407 @default.
- W1990992912 hasConcept C519581460 @default.
- W1990992912 hasConcept C71924100 @default.
- W1990992912 hasConceptScore W1990992912C126322002 @default.
- W1990992912 hasConceptScore W1990992912C134018914 @default.
- W1990992912 hasConceptScore W1990992912C164027704 @default.
- W1990992912 hasConceptScore W1990992912C170493617 @default.
- W1990992912 hasConceptScore W1990992912C2776914184 @default.
- W1990992912 hasConceptScore W1990992912C2776992346 @default.
- W1990992912 hasConceptScore W1990992912C2777622882 @default.
- W1990992912 hasConceptScore W1990992912C2778010969 @default.
- W1990992912 hasConceptScore W1990992912C2779591629 @default.
- W1990992912 hasConceptScore W1990992912C2780419564 @default.
- W1990992912 hasConceptScore W1990992912C2780733407 @default.
- W1990992912 hasConceptScore W1990992912C519581460 @default.
- W1990992912 hasConceptScore W1990992912C71924100 @default.
- W1990992912 hasIssue "14" @default.
- W1990992912 hasLocation W19909929121 @default.
- W1990992912 hasLocation W19909929122 @default.
- W1990992912 hasOpenAccess W1990992912 @default.
- W1990992912 hasPrimaryLocation W19909929121 @default.
- W1990992912 hasRelatedWork W1509822090 @default.
- W1990992912 hasRelatedWork W1978269165 @default.
- W1990992912 hasRelatedWork W1993137140 @default.
- W1990992912 hasRelatedWork W2085449603 @default.
- W1990992912 hasRelatedWork W2091193879 @default.
- W1990992912 hasRelatedWork W2092620816 @default.
- W1990992912 hasRelatedWork W2137175764 @default.
- W1990992912 hasRelatedWork W2151554519 @default.
- W1990992912 hasRelatedWork W2164913792 @default.
- W1990992912 hasRelatedWork W3172103796 @default.
- W1990992912 hasVolume "99" @default.
- W1990992912 isParatext "false" @default.
- W1990992912 isRetracted "false" @default.
- W1990992912 magId "1990992912" @default.
- W1990992912 workType "article" @default.