Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990995969> ?p ?o ?g. }
- W1990995969 endingPage "271" @default.
- W1990995969 startingPage "257" @default.
- W1990995969 abstract "HER2-targeted therapies have radically changed the prognosis of HER2-positive breast cancer over the last few years. However, resistance to these therapies has been a constant, leading to treatment-failure and new tumor progression. Recently, the kinase-impaired HER3 emerged as a pivotal player in oncogenic signaling, with an important role in both non-treated progression and treatment response. HER2/HER3 dimerization is required for full signaling potential and constitutes the key oncogenic unit. Also, when inhibiting PI3K/AKT pathway (as with anti-HER2 drugs) feedback mechanisms lead to a rebound in HER3 activity, which is one of the main roads to resistance. As current strategies to treat HER2-positive breast cancer are unable to inhibit this feedback response, two great promises emerged: the combination of targeted-therapies and drugs targeting HER3. In this article HER2 and HER3-targeted drugs and possible combinations between them, as well as the biomarkers to predict and monitor these drugs effect, are reviewed." @default.
- W1990995969 created "2016-06-24" @default.
- W1990995969 creator A5015356197 @default.
- W1990995969 creator A5022430676 @default.
- W1990995969 creator A5079794846 @default.
- W1990995969 creator A5081800814 @default.
- W1990995969 creator A5091749871 @default.
- W1990995969 date "2015-03-01" @default.
- W1990995969 modified "2023-09-25" @default.
- W1990995969 title "Targeting HER family in HER2-positive metastatic breast cancer: potential biomarkers and novel targeted therapies" @default.
- W1990995969 cites W1582187753 @default.
- W1990995969 cites W1964321121 @default.
- W1990995969 cites W1966598535 @default.
- W1990995969 cites W1969653304 @default.
- W1990995969 cites W1978421730 @default.
- W1990995969 cites W1993804787 @default.
- W1990995969 cites W1997579117 @default.
- W1990995969 cites W1999814889 @default.
- W1990995969 cites W2001739596 @default.
- W1990995969 cites W2009218955 @default.
- W1990995969 cites W2010373607 @default.
- W1990995969 cites W2010601523 @default.
- W1990995969 cites W2014457594 @default.
- W1990995969 cites W2017081079 @default.
- W1990995969 cites W2017693082 @default.
- W1990995969 cites W2018204057 @default.
- W1990995969 cites W2027515445 @default.
- W1990995969 cites W2037737356 @default.
- W1990995969 cites W2040142253 @default.
- W1990995969 cites W2052953726 @default.
- W1990995969 cites W2059769719 @default.
- W1990995969 cites W2060362748 @default.
- W1990995969 cites W2061764831 @default.
- W1990995969 cites W2063819389 @default.
- W1990995969 cites W2066081464 @default.
- W1990995969 cites W2069526613 @default.
- W1990995969 cites W2070727232 @default.
- W1990995969 cites W2088145034 @default.
- W1990995969 cites W2090237134 @default.
- W1990995969 cites W2091164695 @default.
- W1990995969 cites W2092897704 @default.
- W1990995969 cites W2095659509 @default.
- W1990995969 cites W2096362504 @default.
- W1990995969 cites W2097255042 @default.
- W1990995969 cites W2098827180 @default.
- W1990995969 cites W2106787323 @default.
- W1990995969 cites W2107846614 @default.
- W1990995969 cites W2110444464 @default.
- W1990995969 cites W2112522176 @default.
- W1990995969 cites W2116424772 @default.
- W1990995969 cites W2117123328 @default.
- W1990995969 cites W2120213327 @default.
- W1990995969 cites W2120661754 @default.
- W1990995969 cites W2128196636 @default.
- W1990995969 cites W2128307445 @default.
- W1990995969 cites W2129484423 @default.
- W1990995969 cites W2129750399 @default.
- W1990995969 cites W2129837161 @default.
- W1990995969 cites W2133105825 @default.
- W1990995969 cites W2137086207 @default.
- W1990995969 cites W2138523273 @default.
- W1990995969 cites W2139135964 @default.
- W1990995969 cites W2139444209 @default.
- W1990995969 cites W2141393790 @default.
- W1990995969 cites W2141525353 @default.
- W1990995969 cites W2143651667 @default.
- W1990995969 cites W2145477245 @default.
- W1990995969 cites W2146284460 @default.
- W1990995969 cites W2154246971 @default.
- W1990995969 cites W2155228605 @default.
- W1990995969 cites W2158859033 @default.
- W1990995969 cites W2159459001 @default.
- W1990995969 cites W2159639650 @default.
- W1990995969 cites W2159967578 @default.
- W1990995969 cites W2160499123 @default.
- W1990995969 cites W2160574552 @default.
- W1990995969 cites W2160892471 @default.
- W1990995969 cites W2161428561 @default.
- W1990995969 cites W2165226517 @default.
- W1990995969 cites W2166199281 @default.
- W1990995969 cites W2170241131 @default.
- W1990995969 cites W2222638000 @default.
- W1990995969 cites W2271179689 @default.
- W1990995969 cites W2315705238 @default.
- W1990995969 cites W2318605753 @default.
- W1990995969 cites W4234749243 @default.
- W1990995969 doi "https://doi.org/10.2217/pgs.14.133" @default.
- W1990995969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25712189" @default.
- W1990995969 hasPublicationYear "2015" @default.
- W1990995969 type Work @default.
- W1990995969 sameAs 1990995969 @default.
- W1990995969 citedByCount "23" @default.
- W1990995969 countsByYear W19909959692015 @default.
- W1990995969 countsByYear W19909959692016 @default.
- W1990995969 countsByYear W19909959692017 @default.
- W1990995969 countsByYear W19909959692018 @default.
- W1990995969 countsByYear W19909959692019 @default.
- W1990995969 countsByYear W19909959692020 @default.