FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990997412> ?p ?o ?g. }

• W1990997412 endingPage "285" @default.
• W1990997412 startingPage "277" @default.
• W1990997412 abstract "During mouse pancreas development, the transient expression of Neurogenin3 (Neurog3) in uncommitted pancreas progenitors is required to determine endocrine destiny. However it has been reported that Neurog3-expressing cells can eventually adopt acinar or ductal fates and that Neurog3 levels were important to secure the islet destiny. It is not known whether the competence of Neurog3-induced cells to give rise to non-endocrine lineages is an intrinsic property of these progenitors or depends on pancreas developmental stage. Using temporal genetic labeling approaches we examined the dynamic of endocrine progenitor differentiation and explored the plasticity of Neurog3-induced cells throughout development. We found that Neurog3(+) progenitors develop into hormone-expressing cells in a fast process taking less then 10h. Furthermore, fate-mapping studies in heterozygote (Neurog3(CreERT/+)) and Neurog3-deficient (Neurog3(CreERT/CreERT)) embryos revealed that Neurog3-induced cells have different potential over time. At the early bud stage, failed endocrine progenitors can adopt acinar or ductal fate, whereas later in the branching pancreas they do not contribute to the acinar lineage but Neurog3-deficient cells eventually differentiate into duct cells. Thus these results provide evidence that the plasticity of Neurog3-induced cells becomes restricted during development. Furthermore these data suggest that during the secondary transition, endocrine progenitor cells arise from bipotent precursors already committed to the duct/endocrine lineages and not from domain of cells having distinct potentialities." @default.
• W1990997412 created "2016-06-24" @default.
• W1990997412 creator A5009159671 @default.
• W1990997412 creator A5015984702 @default.
• W1990997412 creator A5042936779 @default.
• W1990997412 creator A5049656203 @default.
• W1990997412 creator A5058540019 @default.
• W1990997412 creator A5059214573 @default.
• W1990997412 date "2012-01-01" @default.
• W1990997412 modified "2023-09-30" @default.
• W1990997412 title "Competence of failed endocrine progenitors to give rise to acinar but not ductal cells is restricted to early pancreas development" @default.
• W1990997412 cites W1608404232 @default.
• W1990997412 cites W1721336579 @default.
• W1990997412 cites W1768274470 @default.
• W1990997412 cites W1830287761 @default.
• W1990997412 cites W1981362835 @default.
• W1990997412 cites W1985708072 @default.
• W1990997412 cites W1990826732 @default.
• W1990997412 cites W1993055783 @default.
• W1990997412 cites W2006017090 @default.
• W1990997412 cites W2010399023 @default.
• W1990997412 cites W2011710385 @default.
• W1990997412 cites W2031337142 @default.
• W1990997412 cites W2031959007 @default.
• W1990997412 cites W2041777158 @default.
• W1990997412 cites W2042742511 @default.
• W1990997412 cites W2044638670 @default.
• W1990997412 cites W2052234382 @default.
• W1990997412 cites W2054361177 @default.
• W1990997412 cites W2056058916 @default.
• W1990997412 cites W2056123267 @default.
• W1990997412 cites W2057906413 @default.
• W1990997412 cites W2089328941 @default.
• W1990997412 cites W2107414039 @default.
• W1990997412 cites W2109627278 @default.
• W1990997412 cites W2110447217 @default.
• W1990997412 cites W2110982118 @default.
• W1990997412 cites W2112754181 @default.
• W1990997412 cites W2113430812 @default.
• W1990997412 cites W2122245493 @default.
• W1990997412 cites W2131145532 @default.
• W1990997412 cites W2137987484 @default.
• W1990997412 cites W2141421937 @default.
• W1990997412 cites W2148078342 @default.
• W1990997412 cites W2160400743 @default.
• W1990997412 cites W2162822589 @default.
• W1990997412 cites W2169745228 @default.
• W1990997412 cites W2223979714 @default.
• W1990997412 doi "https://doi.org/10.1016/j.ydbio.2011.10.025" @default.
• W1990997412 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3251922" @default.
• W1990997412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22056785" @default.
• W1990997412 hasPublicationYear "2012" @default.
• W1990997412 type Work @default.
• W1990997412 sameAs 1990997412 @default.
• W1990997412 citedByCount "32" @default.
• W1990997412 countsByYear W19909974122012 @default.
• W1990997412 countsByYear W19909974122013 @default.
• W1990997412 countsByYear W19909974122014 @default.
• W1990997412 countsByYear W19909974122015 @default.
• W1990997412 countsByYear W19909974122016 @default.
• W1990997412 countsByYear W19909974122017 @default.
• W1990997412 countsByYear W19909974122018 @default.
• W1990997412 countsByYear W19909974122019 @default.
• W1990997412 countsByYear W19909974122021 @default.
• W1990997412 crossrefType "journal-article" @default.
• W1990997412 hasAuthorship W1990997412A5009159671 @default.
• W1990997412 hasAuthorship W1990997412A5015984702 @default.
• W1990997412 hasAuthorship W1990997412A5042936779 @default.
• W1990997412 hasAuthorship W1990997412A5049656203 @default.
• W1990997412 hasAuthorship W1990997412A5058540019 @default.
• W1990997412 hasAuthorship W1990997412A5059214573 @default.
• W1990997412 hasBestOaLocation W19909974121 @default.
• W1990997412 hasConcept C103395026 @default.
• W1990997412 hasConcept C134018914 @default.
• W1990997412 hasConcept C15729860 @default.
• W1990997412 hasConcept C201750760 @default.
• W1990997412 hasConcept C2778148616 @default.
• W1990997412 hasConcept C2778764654 @default.
• W1990997412 hasConcept C28328180 @default.
• W1990997412 hasConcept C46699223 @default.
• W1990997412 hasConcept C71315377 @default.
• W1990997412 hasConcept C86803240 @default.
• W1990997412 hasConcept C95444343 @default.
• W1990997412 hasConceptScore W1990997412C103395026 @default.
• W1990997412 hasConceptScore W1990997412C134018914 @default.
• W1990997412 hasConceptScore W1990997412C15729860 @default.
• W1990997412 hasConceptScore W1990997412C201750760 @default.
• W1990997412 hasConceptScore W1990997412C2778148616 @default.
• W1990997412 hasConceptScore W1990997412C2778764654 @default.
• W1990997412 hasConceptScore W1990997412C28328180 @default.
• W1990997412 hasConceptScore W1990997412C46699223 @default.
• W1990997412 hasConceptScore W1990997412C71315377 @default.
• W1990997412 hasConceptScore W1990997412C86803240 @default.
• W1990997412 hasConceptScore W1990997412C95444343 @default.
• W1990997412 hasFunder F4320321589 @default.
• W1990997412 hasFunder F4320332161 @default.
• W1990997412 hasFunder F4320337357 @default.
• W1990997412 hasIssue "2" @default.

• next