FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991000319> ?p ?o ?g. }

• W1991000319 endingPage "9" @default.
• W1991000319 startingPage "1" @default.
• W1991000319 abstract "Glial cell line-derived neurotrophic factor (GDNF) has been identified as a potent survival factor for both central and peripheral neurons. GDNF has been shown to be a potent survival factor for motor neurons during programmed cell death and continuous treatment with GDNF maintains hyperinnervation of skeletal muscle in adulthood. However, little is known about factors regulating normal production of endogenous GDNF in skeletal muscle. This study aimed to examine the role that motor neurons play in regulating GDNF secretion by skeletal muscle. A co-culture of skeletal muscle cells (C2C12) and cholinergic neurons, glioma × neuroblastoma hybrid cells (NG108-15) were used to create nerve-muscle interactions in vitro. Acetylcholine receptors (AChRs) on nerve–myotube co-cultures were blocked with alpha-bungarotoxin (α-BTX). GDNF protein content in cells and in culture medium was analyzed by enzyme-linked immunosorbant assay (ELISA) and western blotting. GDNF localization was examined by immunocytochemistry. The nerve–muscle co-culture study indicated that the addition of motor neurons to skeletal muscle cells reduced the secretion of GDNF by skeletal muscle. The results also showed that blocking AChRs with α-BTX reversed the action of neural cells on GDNF secretion by skeletal muscle. Although ELISA results showed no GDNF in differentiated NG108-15 cells grown alone, immunocytochemical analysis showed that GDNF was localized in NG108-15 cells co-cultured with C2C12 myotubes. These results suggest that motor neurons may be regulating their own supply of GDNF secreted by skeletal muscle and that activation of AChRs may be involved in this process." @default.
• W1991000319 created "2016-06-24" @default.
• W1991000319 creator A5041452527 @default.
• W1991000319 creator A5064596355 @default.
• W1991000319 date "2011-05-01" @default.
• W1991000319 modified "2023-10-17" @default.
• W1991000319 title "Cholinergic neurons regulate secretion of glial cell line-derived neurotrophic factor by skeletal muscle cells in culture" @default.
• W1991000319 cites W1844154778 @default.
• W1991000319 cites W1971644755 @default.
• W1991000319 cites W1975964507 @default.
• W1991000319 cites W1989434542 @default.
• W1991000319 cites W1989744157 @default.
• W1991000319 cites W1994452959 @default.
• W1991000319 cites W1995729951 @default.
• W1991000319 cites W1998953662 @default.
• W1991000319 cites W2003783012 @default.
• W1991000319 cites W2009705816 @default.
• W1991000319 cites W2013884827 @default.
• W1991000319 cites W2017286200 @default.
• W1991000319 cites W2020023197 @default.
• W1991000319 cites W2030404710 @default.
• W1991000319 cites W2034261648 @default.
• W1991000319 cites W2039317677 @default.
• W1991000319 cites W2048028185 @default.
• W1991000319 cites W2053365512 @default.
• W1991000319 cites W2054810445 @default.
• W1991000319 cites W2060747165 @default.
• W1991000319 cites W2065819744 @default.
• W1991000319 cites W2069210581 @default.
• W1991000319 cites W2072027696 @default.
• W1991000319 cites W2073947804 @default.
• W1991000319 cites W2082584428 @default.
• W1991000319 cites W2085766554 @default.
• W1991000319 cites W2093230613 @default.
• W1991000319 cites W2103706525 @default.
• W1991000319 cites W2111016560 @default.
• W1991000319 cites W2128524394 @default.
• W1991000319 cites W2136511265 @default.
• W1991000319 cites W2139696718 @default.
• W1991000319 cites W2076922057 @default.
• W1991000319 doi "https://doi.org/10.1016/j.brainres.2011.03.030" @default.
• W1991000319 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3085632" @default.
• W1991000319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21420941" @default.
• W1991000319 hasPublicationYear "2011" @default.
• W1991000319 type Work @default.
• W1991000319 sameAs 1991000319 @default.
• W1991000319 citedByCount "21" @default.
• W1991000319 countsByYear W19910003192012 @default.
• W1991000319 countsByYear W19910003192013 @default.
• W1991000319 countsByYear W19910003192014 @default.
• W1991000319 countsByYear W19910003192015 @default.
• W1991000319 countsByYear W19910003192017 @default.
• W1991000319 countsByYear W19910003192020 @default.
• W1991000319 countsByYear W19910003192022 @default.
• W1991000319 countsByYear W19910003192023 @default.
• W1991000319 crossrefType "journal-article" @default.
• W1991000319 hasAuthorship W1991000319A5041452527 @default.
• W1991000319 hasAuthorship W1991000319A5064596355 @default.
• W1991000319 hasBestOaLocation W19910003192 @default.
• W1991000319 hasConcept C104966671 @default.
• W1991000319 hasConcept C126322002 @default.
• W1991000319 hasConcept C134018914 @default.
• W1991000319 hasConcept C160539049 @default.
• W1991000319 hasConcept C169760540 @default.
• W1991000319 hasConcept C170493617 @default.
• W1991000319 hasConcept C185856081 @default.
• W1991000319 hasConcept C207200792 @default.
• W1991000319 hasConcept C22885893 @default.
• W1991000319 hasConcept C2779959927 @default.
• W1991000319 hasConcept C35866371 @default.
• W1991000319 hasConcept C3763915 @default.
• W1991000319 hasConcept C55493867 @default.
• W1991000319 hasConcept C60278653 @default.
• W1991000319 hasConcept C71924100 @default.
• W1991000319 hasConcept C86803240 @default.
• W1991000319 hasConcept C94296188 @default.
• W1991000319 hasConcept C95444343 @default.
• W1991000319 hasConceptScore W1991000319C104966671 @default.
• W1991000319 hasConceptScore W1991000319C126322002 @default.
• W1991000319 hasConceptScore W1991000319C134018914 @default.
• W1991000319 hasConceptScore W1991000319C160539049 @default.
• W1991000319 hasConceptScore W1991000319C169760540 @default.
• W1991000319 hasConceptScore W1991000319C170493617 @default.
• W1991000319 hasConceptScore W1991000319C185856081 @default.
• W1991000319 hasConceptScore W1991000319C207200792 @default.
• W1991000319 hasConceptScore W1991000319C22885893 @default.
• W1991000319 hasConceptScore W1991000319C2779959927 @default.
• W1991000319 hasConceptScore W1991000319C35866371 @default.
• W1991000319 hasConceptScore W1991000319C3763915 @default.
• W1991000319 hasConceptScore W1991000319C55493867 @default.
• W1991000319 hasConceptScore W1991000319C60278653 @default.
• W1991000319 hasConceptScore W1991000319C71924100 @default.
• W1991000319 hasConceptScore W1991000319C86803240 @default.
• W1991000319 hasConceptScore W1991000319C94296188 @default.
• W1991000319 hasConceptScore W1991000319C95444343 @default.
• W1991000319 hasFunder F4320309563 @default.
• W1991000319 hasLocation W19910003191 @default.
• W1991000319 hasLocation W19910003192 @default.

• next