FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991001320> ?p ?o ?g. }

• W1991001320 endingPage "45" @default.
• W1991001320 startingPage "41" @default.
• W1991001320 abstract "Objective. Tumor necrosis factor-α (TNF-α) antagonists bring about significant improvement in chronic inflammatory diseases such as rheumatoid arthritis (RA) and spondyloarthritis (SpA). There is some evidence that they can also have negative myocardial effects, but to date this issue has not been clarified. We evaluated changes in electrocardiographic measures [QT interval, corrected, dispersion, and dispersion corrected (QT, QTc, QTd, QTdc, respectively)] in patients with RA or SpA treated with anti-TNF agents (infliximab and etanercept), those treated with other biological agents (rituximab), and with methotrexate. Methods. We studied 38 consecutive patients with RA (21 patients) or SpA (19 patients) being treated with TNF-α antagonists, 8 patients with RA being treated with rituximab, and 13 patients (8 with RA and 5 with SpA) taking methotrexate. Electrocardiographs (ECG) were performed on all participants at baseline and 12 months after initiation of treatment, and the QT, QTc, and QTd were calculated with standard procedures. Results. After 12 months of treatment, significant increases over baseline values were observed in the mean QT (p < 0.009), QTd (p < 0.0001), and QTdc (p < 0.0001) of the anti-TNF group, but no significant changes were observed in those taking rituximab. QT changes in the anti-TNF group were unrelated to the disease (RA vs SpA) or drug (infliximab vs etanercept), and none were associated with clinical manifestations of cardiac disease. Conclusion. In patients with RA and SpA, TNF-α antagonists seem to increase the QT and QTd measures. Although these changes were completely asymptomatic, ECG may be indicated in patients being considered for anti-TNF therapy to identify those at risk for cardiac complications." @default.
• W1991001320 created "2016-06-24" @default.
• W1991001320 creator A5039970068 @default.
• W1991001320 creator A5041485901 @default.
• W1991001320 creator A5044480806 @default.
• W1991001320 creator A5079992777 @default.
• W1991001320 creator A5083687141 @default.
• W1991001320 creator A5087114501 @default.
• W1991001320 creator A5089912115 @default.
• W1991001320 date "2011-11-01" @default.
• W1991001320 modified "2023-10-15" @default.
• W1991001320 title "Biological Drug Treatment of Rheumatoid Arthritis and Spondyloarthritis: Effects on QT Interval and QT Dispersion" @default.
• W1991001320 cites W1983015524 @default.
• W1991001320 cites W1987312456 @default.
• W1991001320 cites W1992424884 @default.
• W1991001320 cites W2008860329 @default.
• W1991001320 cites W2010988235 @default.
• W1991001320 cites W2012576732 @default.
• W1991001320 cites W2016782456 @default.
• W1991001320 cites W2017769012 @default.
• W1991001320 cites W2031060162 @default.
• W1991001320 cites W2037921660 @default.
• W1991001320 cites W2037976962 @default.
• W1991001320 cites W2039138983 @default.
• W1991001320 cites W2047427653 @default.
• W1991001320 cites W2068821113 @default.
• W1991001320 cites W2086266200 @default.
• W1991001320 cites W2102980544 @default.
• W1991001320 cites W2104679117 @default.
• W1991001320 cites W2116581628 @default.
• W1991001320 cites W2131308754 @default.
• W1991001320 cites W2138784551 @default.
• W1991001320 cites W2145175796 @default.
• W1991001320 cites W2150114083 @default.
• W1991001320 cites W2152348310 @default.
• W1991001320 cites W2159513257 @default.
• W1991001320 cites W2161999690 @default.
• W1991001320 cites W2170874916 @default.
• W1991001320 doi "https://doi.org/10.3899/jrheum.110158" @default.
• W1991001320 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22045840" @default.
• W1991001320 hasPublicationYear "2011" @default.
• W1991001320 type Work @default.
• W1991001320 sameAs 1991001320 @default.
• W1991001320 citedByCount "11" @default.
• W1991001320 countsByYear W19910013202016 @default.
• W1991001320 countsByYear W19910013202017 @default.
• W1991001320 countsByYear W19910013202018 @default.
• W1991001320 countsByYear W19910013202019 @default.
• W1991001320 countsByYear W19910013202020 @default.
• W1991001320 countsByYear W19910013202022 @default.
• W1991001320 crossrefType "journal-article" @default.
• W1991001320 hasAuthorship W1991001320A5039970068 @default.
• W1991001320 hasAuthorship W1991001320A5041485901 @default.
• W1991001320 hasAuthorship W1991001320A5044480806 @default.
• W1991001320 hasAuthorship W1991001320A5079992777 @default.
• W1991001320 hasAuthorship W1991001320A5083687141 @default.
• W1991001320 hasAuthorship W1991001320A5087114501 @default.
• W1991001320 hasAuthorship W1991001320A5089912115 @default.
• W1991001320 hasBestOaLocation W19910013201 @default.
• W1991001320 hasConcept C118441451 @default.
• W1991001320 hasConcept C126322002 @default.
• W1991001320 hasConcept C17991360 @default.
• W1991001320 hasConcept C2777138892 @default.
• W1991001320 hasConcept C2777226972 @default.
• W1991001320 hasConcept C2777575956 @default.
• W1991001320 hasConcept C2777910003 @default.
• W1991001320 hasConcept C2779338263 @default.
• W1991001320 hasConcept C2780132546 @default.
• W1991001320 hasConcept C2780653079 @default.
• W1991001320 hasConcept C2781059491 @default.
• W1991001320 hasConcept C71924100 @default.
• W1991001320 hasConcept C90924648 @default.
• W1991001320 hasConceptScore W1991001320C118441451 @default.
• W1991001320 hasConceptScore W1991001320C126322002 @default.
• W1991001320 hasConceptScore W1991001320C17991360 @default.
• W1991001320 hasConceptScore W1991001320C2777138892 @default.
• W1991001320 hasConceptScore W1991001320C2777226972 @default.
• W1991001320 hasConceptScore W1991001320C2777575956 @default.
• W1991001320 hasConceptScore W1991001320C2777910003 @default.
• W1991001320 hasConceptScore W1991001320C2779338263 @default.
• W1991001320 hasConceptScore W1991001320C2780132546 @default.
• W1991001320 hasConceptScore W1991001320C2780653079 @default.
• W1991001320 hasConceptScore W1991001320C2781059491 @default.
• W1991001320 hasConceptScore W1991001320C71924100 @default.
• W1991001320 hasConceptScore W1991001320C90924648 @default.
• W1991001320 hasIssue "1" @default.
• W1991001320 hasLocation W19910013201 @default.
• W1991001320 hasLocation W19910013202 @default.
• W1991001320 hasLocation W19910013203 @default.
• W1991001320 hasOpenAccess W1991001320 @default.
• W1991001320 hasPrimaryLocation W19910013201 @default.
• W1991001320 hasRelatedWork W1973470095 @default.
• W1991001320 hasRelatedWork W1976481621 @default.
• W1991001320 hasRelatedWork W1993992685 @default.
• W1991001320 hasRelatedWork W2038285281 @default.
• W1991001320 hasRelatedWork W2064215099 @default.
• W1991001320 hasRelatedWork W2095714646 @default.
• W1991001320 hasRelatedWork W2141436693 @default.

• next