Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991008945> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1991008945 endingPage "415" @default.
- W1991008945 startingPage "403" @default.
- W1991008945 abstract "Intensive chemotherapy in patients with leukemia produces immunosuppression. The level of immunocompetence correlates with prognosis. The immunological function of 29 children with acute lymphoblastic leukemia (ALL) in complete remission and on 2 different maintenance therapies was evaluated and compared with 16 normal children (Group A). Sixteen children (Group B) with ALL received 6 mercaptopurine (6MP) daily and methotrexate (MTX) twice a week, and 13 children (Group C) received 6MP and MTX weekly for maintenance. There was depression of both cellular immunity, measured by the number of T cells and skin tests, and humoral immunity, measured by number of B cells, primary antibody production to typhoid vaccine, and levels of immunoglobulins. However, continuous maintenance therapy (Group B) produced significantly more severe immunosuppression of cellular immunity than the intermittent therapy (Group C). Humoral immunity was equally depressed in both groups of leukemia patients, but was less altered than cellular immunity. Concomitantly, patients with intermittent maintenance chemotherapy had less hematologic depression, fewer episodes of infection, and fewer died in complete remission. Patients of both groups with higher levels of immunocompetence had better prognosis with longer duration of complete remission than patients with severe immunosuppression. Out of 6 patients with “favorable immunocompetence” only 1 relapsed at 7 months and the other 5 remain in complete remission from 8 to 31 months. Among 23 leukemic patients with “unfavorable immunocompetence,” 15 relapsed and 8 remain in complete remission from 9 to 26 months." @default.
- W1991008945 created "2016-06-24" @default.
- W1991008945 creator A5007007507 @default.
- W1991008945 creator A5027131553 @default.
- W1991008945 creator A5040300777 @default.
- W1991008945 creator A5053292305 @default.
- W1991008945 creator A5083190653 @default.
- W1991008945 creator A5089828940 @default.
- W1991008945 date "1976-01-01" @default.
- W1991008945 modified "2023-10-03" @default.
- W1991008945 title "Immunocompetence and prognosis in children with acute lymphoblastic leukemia: Combination of two different maintenance therapies" @default.
- W1991008945 cites W2002983094 @default.
- W1991008945 cites W2005255139 @default.
- W1991008945 cites W2013188055 @default.
- W1991008945 cites W2027793972 @default.
- W1991008945 cites W2041460620 @default.
- W1991008945 cites W2128461204 @default.
- W1991008945 cites W2162701168 @default.
- W1991008945 cites W2170410865 @default.
- W1991008945 cites W2317096380 @default.
- W1991008945 cites W2407061276 @default.
- W1991008945 cites W2419624115 @default.
- W1991008945 doi "https://doi.org/10.1002/mpo.2950020407" @default.
- W1991008945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1069898" @default.
- W1991008945 hasPublicationYear "1976" @default.
- W1991008945 type Work @default.
- W1991008945 sameAs 1991008945 @default.
- W1991008945 citedByCount "13" @default.
- W1991008945 crossrefType "journal-article" @default.
- W1991008945 hasAuthorship W1991008945A5007007507 @default.
- W1991008945 hasAuthorship W1991008945A5027131553 @default.
- W1991008945 hasAuthorship W1991008945A5040300777 @default.
- W1991008945 hasAuthorship W1991008945A5053292305 @default.
- W1991008945 hasAuthorship W1991008945A5083190653 @default.
- W1991008945 hasAuthorship W1991008945A5089828940 @default.
- W1991008945 hasConcept C126322002 @default.
- W1991008945 hasConcept C203014093 @default.
- W1991008945 hasConcept C2776548049 @default.
- W1991008945 hasConcept C2776694085 @default.
- W1991008945 hasConcept C2777422395 @default.
- W1991008945 hasConcept C2778283404 @default.
- W1991008945 hasConcept C2778461978 @default.
- W1991008945 hasConcept C2779341262 @default.
- W1991008945 hasConcept C2780252810 @default.
- W1991008945 hasConcept C2781059491 @default.
- W1991008945 hasConcept C2781107101 @default.
- W1991008945 hasConcept C2909962599 @default.
- W1991008945 hasConcept C3017875465 @default.
- W1991008945 hasConcept C71924100 @default.
- W1991008945 hasConcept C8891405 @default.
- W1991008945 hasConceptScore W1991008945C126322002 @default.
- W1991008945 hasConceptScore W1991008945C203014093 @default.
- W1991008945 hasConceptScore W1991008945C2776548049 @default.
- W1991008945 hasConceptScore W1991008945C2776694085 @default.
- W1991008945 hasConceptScore W1991008945C2777422395 @default.
- W1991008945 hasConceptScore W1991008945C2778283404 @default.
- W1991008945 hasConceptScore W1991008945C2778461978 @default.
- W1991008945 hasConceptScore W1991008945C2779341262 @default.
- W1991008945 hasConceptScore W1991008945C2780252810 @default.
- W1991008945 hasConceptScore W1991008945C2781059491 @default.
- W1991008945 hasConceptScore W1991008945C2781107101 @default.
- W1991008945 hasConceptScore W1991008945C2909962599 @default.
- W1991008945 hasConceptScore W1991008945C3017875465 @default.
- W1991008945 hasConceptScore W1991008945C71924100 @default.
- W1991008945 hasConceptScore W1991008945C8891405 @default.
- W1991008945 hasIssue "4" @default.
- W1991008945 hasLocation W19910089451 @default.
- W1991008945 hasLocation W19910089452 @default.
- W1991008945 hasOpenAccess W1991008945 @default.
- W1991008945 hasPrimaryLocation W19910089451 @default.
- W1991008945 hasRelatedWork W124612284 @default.
- W1991008945 hasRelatedWork W187703812 @default.
- W1991008945 hasRelatedWork W1975225419 @default.
- W1991008945 hasRelatedWork W2031253481 @default.
- W1991008945 hasRelatedWork W2112819617 @default.
- W1991008945 hasRelatedWork W2357199695 @default.
- W1991008945 hasRelatedWork W2400266751 @default.
- W1991008945 hasRelatedWork W4213421740 @default.
- W1991008945 hasRelatedWork W4283821855 @default.
- W1991008945 hasRelatedWork W4381570565 @default.
- W1991008945 hasVolume "2" @default.
- W1991008945 isParatext "false" @default.
- W1991008945 isRetracted "false" @default.
- W1991008945 magId "1991008945" @default.
- W1991008945 workType "article" @default.