Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991015655> ?p ?o ?g. }
- W1991015655 endingPage "50" @default.
- W1991015655 startingPage "42" @default.
- W1991015655 abstract "In this study, we have used two-dimensional electrophoresis, protein sequencing, immunoblotting, and immunohistochemistry to identify proteins that were differentially expressed during aging in human and rat skeletal muscles. Ubiquitin was identified. It was expressed at high levels in old fast-twitch muscles but at low levels in young fast-twitch muscles. It was also discovered that exogenous ubiquitin could suppress the growth of C2C12 cells, in vitro. The reduction in C2C12 cell growth was not attributed to an increase in apoptosis but to an inhibition in cell cycle entry. Furthermore, it was possible to induce muscles to degenerate in vivo by injecting a high dose of exogenous ubiquitin into young healthy skeletal muscles. These results suggest that hyperactivity of the ubiquitin-proteasome pathway is involved in the aging process of fast-twitch muscles. In addition, ubiquitin-dependent growth suppression in satellite cells may be associated with the poor healing potential of old skeletal muscles." @default.
- W1991015655 created "2016-06-24" @default.
- W1991015655 creator A5030872921 @default.
- W1991015655 creator A5042277250 @default.
- W1991015655 creator A5055960115 @default.
- W1991015655 creator A5072303641 @default.
- W1991015655 creator A5077627215 @default.
- W1991015655 date "2004-05-01" @default.
- W1991015655 modified "2023-10-10" @default.
- W1991015655 title "Ubiquitin expression is up-regulated in human and rat skeletal muscles during aging" @default.
- W1991015655 cites W1489591743 @default.
- W1991015655 cites W161994666 @default.
- W1991015655 cites W1723026733 @default.
- W1991015655 cites W1729354010 @default.
- W1991015655 cites W1799879229 @default.
- W1991015655 cites W1870980090 @default.
- W1991015655 cites W1970909662 @default.
- W1991015655 cites W1972984824 @default.
- W1991015655 cites W1975884987 @default.
- W1991015655 cites W1979408355 @default.
- W1991015655 cites W1979888967 @default.
- W1991015655 cites W1980189287 @default.
- W1991015655 cites W1981327989 @default.
- W1991015655 cites W1981916517 @default.
- W1991015655 cites W1983919306 @default.
- W1991015655 cites W1984111867 @default.
- W1991015655 cites W1997546274 @default.
- W1991015655 cites W1999098583 @default.
- W1991015655 cites W2004497980 @default.
- W1991015655 cites W2005247710 @default.
- W1991015655 cites W2015997780 @default.
- W1991015655 cites W2018571987 @default.
- W1991015655 cites W2021009107 @default.
- W1991015655 cites W2022961230 @default.
- W1991015655 cites W2025039213 @default.
- W1991015655 cites W2031569153 @default.
- W1991015655 cites W2033967854 @default.
- W1991015655 cites W2034496259 @default.
- W1991015655 cites W2040607662 @default.
- W1991015655 cites W2045593834 @default.
- W1991015655 cites W2047117385 @default.
- W1991015655 cites W2050277077 @default.
- W1991015655 cites W2081079988 @default.
- W1991015655 cites W2081744774 @default.
- W1991015655 cites W2083405476 @default.
- W1991015655 cites W2083615074 @default.
- W1991015655 cites W2087721389 @default.
- W1991015655 cites W2087803244 @default.
- W1991015655 cites W2114918609 @default.
- W1991015655 cites W2132024812 @default.
- W1991015655 cites W2139352935 @default.
- W1991015655 cites W2144074899 @default.
- W1991015655 cites W2153188529 @default.
- W1991015655 cites W2175093343 @default.
- W1991015655 cites W2176966894 @default.
- W1991015655 cites W2176985336 @default.
- W1991015655 cites W2178503716 @default.
- W1991015655 cites W2313109730 @default.
- W1991015655 cites W2317210331 @default.
- W1991015655 cites W2321385920 @default.
- W1991015655 cites W2322424896 @default.
- W1991015655 cites W4249768868 @default.
- W1991015655 cites W4251683570 @default.
- W1991015655 cites W4293247451 @default.
- W1991015655 cites W4378799180 @default.
- W1991015655 doi "https://doi.org/10.1016/j.abb.2004.02.027" @default.
- W1991015655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15081892" @default.
- W1991015655 hasPublicationYear "2004" @default.
- W1991015655 type Work @default.
- W1991015655 sameAs 1991015655 @default.
- W1991015655 citedByCount "55" @default.
- W1991015655 countsByYear W19910156552012 @default.
- W1991015655 countsByYear W19910156552014 @default.
- W1991015655 countsByYear W19910156552015 @default.
- W1991015655 countsByYear W19910156552016 @default.
- W1991015655 countsByYear W19910156552017 @default.
- W1991015655 countsByYear W19910156552018 @default.
- W1991015655 countsByYear W19910156552019 @default.
- W1991015655 countsByYear W19910156552021 @default.
- W1991015655 countsByYear W19910156552022 @default.
- W1991015655 crossrefType "journal-article" @default.
- W1991015655 hasAuthorship W1991015655A5030872921 @default.
- W1991015655 hasAuthorship W1991015655A5042277250 @default.
- W1991015655 hasAuthorship W1991015655A5055960115 @default.
- W1991015655 hasAuthorship W1991015655A5072303641 @default.
- W1991015655 hasAuthorship W1991015655A5077627215 @default.
- W1991015655 hasConcept C104317684 @default.
- W1991015655 hasConcept C134018914 @default.
- W1991015655 hasConcept C153911025 @default.
- W1991015655 hasConcept C185592680 @default.
- W1991015655 hasConcept C190283241 @default.
- W1991015655 hasConcept C195580219 @default.
- W1991015655 hasConcept C207200792 @default.
- W1991015655 hasConcept C25602115 @default.
- W1991015655 hasConcept C27740335 @default.
- W1991015655 hasConcept C2779959927 @default.
- W1991015655 hasConcept C3675279 @default.
- W1991015655 hasConcept C3763915 @default.