FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991019780> ?p ?o ?g. }

• W1991019780 endingPage "358" @default.
• W1991019780 startingPage "351" @default.
• W1991019780 abstract "To evaluate the effects of low-dose prostacyclin on intestinal perfusion during endotoxemia.A randomized, blinded experimental study.A university laboratory.Sixteen anesthetized cats.The animals received endotoxin by continuous intravenous infusion (0.5 mg/kg plus 0.5 mg x kg(-1) x hr(-1)) and a continuous volume replacement throughout the experiment. Four hours after the start of endotoxin, the animals were randomized to receive an infusion of either prostacyclin at a dose of 1 ng x kg(-1) x min(-1) (prostacyclin group) or vehicle (control group) during the next 4 hrs.Intestinal vascular resistance was calculated from systemic arterial pressure, central venous pressure, and superior mesenteric artery blood flow, and intestinal oxygen delivery and uptake were calculated from superior mesenteric artery and vein blood samples and blood flow. Interstitial lactate, pyruvate, glucose, and glycerol in the ileal wall were measured by using microdialysis. There were no differences in baseline values between the groups. Systemic blood pressure decreased initially but recovered and remained stable in both groups. In the control group, intestinal vascular resistance increased from 10.9 +/- 1.0 to 24.7 +/- 5.3 mm Hg x mL x min(-1) x kg(-1) (p <.05) at 8 hrs, and oxygen delivery decreased from 2.6 +/- 0.2 to 1.3 +/- 0.3 mL x min(-1) x kg(-1) (p <.05). Simultaneously, microdialysis lactate increased from 1.6 +/- 0.1 to 3.6 +/- 0.5 mmol/L (p <.05) with concomitant pyruvate increase and unchanged lactate/pyruvate ratio. Blood lactate increased and pH decreased. In the prostacyclin group at 8 hrs, intestinal vascular resistance of 6.9 +/- 0.8 mm Hg x mL x min(-1) x kg(-1) was lower and intestinal oxygen delivery of 3.2 +/- 0.3 was higher (p <.05) than in the control group at 8 hrs. Intestinal oxygen uptake of 0.54 +/- 0.10 mL x min(-1) x kg(-1) was higher than in the control group, in which oxygen uptake was 0.26 +/- 0.04 mL x min(-1) x kg(-1). Lactate, pyruvate, and pH were normalized at 8 hrs in the prostacyclin group.Low-dose prostacyclin has beneficial effects on small intestinal perfusion during endotoxemia in this experimental cat model." @default.
• W1991019780 created "2016-06-24" @default.
• W1991019780 creator A5023233134 @default.
• W1991019780 creator A5084430265 @default.
• W1991019780 date "2001-02-01" @default.
• W1991019780 modified "2023-10-17" @default.
• W1991019780 title "Beneficial effects of low-dose prostacyclin on cat intestinal perfusion during endotoxemia as evaluated with microdialysis and oxygen transport variables" @default.
• W1991019780 cites W1964109762 @default.
• W1991019780 cites W1993064069 @default.
• W1991019780 cites W1999392420 @default.
• W1991019780 cites W1999788344 @default.
• W1991019780 cites W2001394229 @default.
• W1991019780 cites W2001697590 @default.
• W1991019780 cites W2002294971 @default.
• W1991019780 cites W2007135488 @default.
• W1991019780 cites W2011464464 @default.
• W1991019780 cites W2020772383 @default.
• W1991019780 cites W2021403302 @default.
• W1991019780 cites W2023242450 @default.
• W1991019780 cites W2028892076 @default.
• W1991019780 cites W2030456606 @default.
• W1991019780 cites W2031846488 @default.
• W1991019780 cites W2037078502 @default.
• W1991019780 cites W2048856505 @default.
• W1991019780 cites W2050867993 @default.
• W1991019780 cites W2052303540 @default.
• W1991019780 cites W2054402026 @default.
• W1991019780 cites W2055833016 @default.
• W1991019780 cites W2059813008 @default.
• W1991019780 cites W2060844478 @default.
• W1991019780 cites W2068275837 @default.
• W1991019780 cites W2070805549 @default.
• W1991019780 cites W2071833178 @default.
• W1991019780 cites W2079493147 @default.
• W1991019780 cites W2083436685 @default.
• W1991019780 cites W2111961055 @default.
• W1991019780 cites W2144499458 @default.
• W1991019780 cites W2419360016 @default.
• W1991019780 cites W4300830264 @default.
• W1991019780 cites W78888789 @default.
• W1991019780 doi "https://doi.org/10.1097/00003246-200102000-00025" @default.
• W1991019780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11246316" @default.
• W1991019780 hasPublicationYear "2001" @default.
• W1991019780 type Work @default.
• W1991019780 sameAs 1991019780 @default.
• W1991019780 citedByCount "17" @default.
• W1991019780 countsByYear W19910197802012 @default.
• W1991019780 crossrefType "journal-article" @default.
• W1991019780 hasAuthorship W1991019780A5023233134 @default.
• W1991019780 hasAuthorship W1991019780A5084430265 @default.
• W1991019780 hasConcept C126322002 @default.
• W1991019780 hasConcept C134018914 @default.
• W1991019780 hasConcept C146957229 @default.
• W1991019780 hasConcept C178853913 @default.
• W1991019780 hasConcept C2781046184 @default.
• W1991019780 hasConcept C2781128415 @default.
• W1991019780 hasConcept C42219234 @default.
• W1991019780 hasConcept C50156730 @default.
• W1991019780 hasConcept C529278444 @default.
• W1991019780 hasConcept C58245268 @default.
• W1991019780 hasConcept C71924100 @default.
• W1991019780 hasConceptScore W1991019780C126322002 @default.
• W1991019780 hasConceptScore W1991019780C134018914 @default.
• W1991019780 hasConceptScore W1991019780C146957229 @default.
• W1991019780 hasConceptScore W1991019780C178853913 @default.
• W1991019780 hasConceptScore W1991019780C2781046184 @default.
• W1991019780 hasConceptScore W1991019780C2781128415 @default.
• W1991019780 hasConceptScore W1991019780C42219234 @default.
• W1991019780 hasConceptScore W1991019780C50156730 @default.
• W1991019780 hasConceptScore W1991019780C529278444 @default.
• W1991019780 hasConceptScore W1991019780C58245268 @default.
• W1991019780 hasConceptScore W1991019780C71924100 @default.
• W1991019780 hasIssue "2" @default.
• W1991019780 hasLocation W19910197801 @default.
• W1991019780 hasLocation W19910197802 @default.
• W1991019780 hasOpenAccess W1991019780 @default.
• W1991019780 hasPrimaryLocation W19910197801 @default.
• W1991019780 hasRelatedWork W1963593847 @default.
• W1991019780 hasRelatedWork W1971961588 @default.
• W1991019780 hasRelatedWork W1989766674 @default.
• W1991019780 hasRelatedWork W1991019780 @default.
• W1991019780 hasRelatedWork W2019086812 @default.
• W1991019780 hasRelatedWork W2045709236 @default.
• W1991019780 hasRelatedWork W2057241772 @default.
• W1991019780 hasRelatedWork W2133205685 @default.
• W1991019780 hasRelatedWork W2407786405 @default.
• W1991019780 hasRelatedWork W2419344602 @default.
• W1991019780 hasVolume "29" @default.
• W1991019780 isParatext "false" @default.
• W1991019780 isRetracted "false" @default.
• W1991019780 magId "1991019780" @default.
• W1991019780 workType "article" @default.