FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991026121> ?p ?o ?g. }

• W1991026121 endingPage "286" @default.
• W1991026121 startingPage "281" @default.
• W1991026121 abstract "The growth and function of the prostate is dependent on androgens. The two predominant androgens are testosterone, which is formed in the testis from androstenedione and 5alpha-dihydrotestosterone, which is formed from testosterone by 5alpha-reductases and is the most active androgen in the prostate. Prostate cancer is one of the most common cancers among men and androgens are involved in controlling the growth of androgen-sensitive malignant prostatic cells. The endocrine therapy used to treat prostate cancer aims to eliminate androgenic activity from the prostatic tissue. Most prostate cancers are initially responsive to androgen withdrawal but become later refractory to the therapy and begin to grow androgen-independently. Using LNCaP prostate cancer cell line we have developed a cell model to study the progression of prostate cancer. In the model androgen-sensitive LNCaP cells are transformed in culture conditions into more aggressive, androgen-independent cells. The model was used to study androgen and estrogen metabolism during the transformation process. Our results indicate that substantial changes in androgen and estrogen metabolism occur in the cells during the process. A remarkable decrease in the oxidative 17beta-hydroxysteroid dehydrogenase activity was seen whereas the reductive activity seemed to increase. The changes suggest that during transformation estrogen influence is increasing in the cells. This is supported by the cDNA microarray screening results which showed over-expression of several genes up-regulated by estrogens in the LNCaP cells line representing progressive prostate cancer. Since local steroid metabolism controls the bioavailability of active steroid hormones in the prostate, the variations in steroid-metabolizing enzymes during cancer progression may be crucial in the regulation of the growth and function of the organ." @default.
• W1991026121 created "2016-06-24" @default.
• W1991026121 creator A5002693527 @default.
• W1991026121 creator A5025569186 @default.
• W1991026121 creator A5035850380 @default.
• W1991026121 creator A5047467006 @default.
• W1991026121 creator A5049245443 @default.
• W1991026121 creator A5064745020 @default.
• W1991026121 creator A5072131496 @default.
• W1991026121 creator A5073475135 @default.
• W1991026121 creator A5075377112 @default.
• W1991026121 creator A5086576972 @default.
• W1991026121 creator A5089260333 @default.
• W1991026121 creator A5090944717 @default.
• W1991026121 date "2004-11-01" @default.
• W1991026121 modified "2023-10-01" @default.
• W1991026121 title "Sex steroid hormone metabolism and prostate cancer" @default.
• W1991026121 cites W1525342509 @default.
• W1991026121 cites W1561060695 @default.
• W1991026121 cites W1967910995 @default.
• W1991026121 cites W1970546734 @default.
• W1991026121 cites W1970964955 @default.
• W1991026121 cites W1971069172 @default.
• W1991026121 cites W1971097859 @default.
• W1991026121 cites W1977189077 @default.
• W1991026121 cites W1979434633 @default.
• W1991026121 cites W1982926605 @default.
• W1991026121 cites W1983100996 @default.
• W1991026121 cites W1989738395 @default.
• W1991026121 cites W1991354897 @default.
• W1991026121 cites W1999504845 @default.
• W1991026121 cites W2006788503 @default.
• W1991026121 cites W2007363086 @default.
• W1991026121 cites W2011762849 @default.
• W1991026121 cites W2014783542 @default.
• W1991026121 cites W2026800989 @default.
• W1991026121 cites W2031465452 @default.
• W1991026121 cites W2038608100 @default.
• W1991026121 cites W2041146811 @default.
• W1991026121 cites W2049232448 @default.
• W1991026121 cites W2055675331 @default.
• W1991026121 cites W2059972525 @default.
• W1991026121 cites W2063246984 @default.
• W1991026121 cites W2081922333 @default.
• W1991026121 cites W2091643266 @default.
• W1991026121 cites W2092195423 @default.
• W1991026121 cites W2093954677 @default.
• W1991026121 cites W2110103797 @default.
• W1991026121 cites W2111482994 @default.
• W1991026121 cites W2125072209 @default.
• W1991026121 cites W2139372640 @default.
• W1991026121 cites W4231286136 @default.
• W1991026121 cites W4233050112 @default.
• W1991026121 cites W4233717237 @default.
• W1991026121 cites W4238598808 @default.
• W1991026121 cites W4240256139 @default.
• W1991026121 cites W4255897877 @default.
• W1991026121 doi "https://doi.org/10.1016/j.jsbmb.2004.10.004" @default.
• W1991026121 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15663991" @default.
• W1991026121 hasPublicationYear "2004" @default.
• W1991026121 type Work @default.
• W1991026121 sameAs 1991026121 @default.
• W1991026121 citedByCount "81" @default.
• W1991026121 countsByYear W19910261212012 @default.
• W1991026121 countsByYear W19910261212013 @default.
• W1991026121 countsByYear W19910261212014 @default.
• W1991026121 countsByYear W19910261212015 @default.
• W1991026121 countsByYear W19910261212016 @default.
• W1991026121 countsByYear W19910261212017 @default.
• W1991026121 countsByYear W19910261212018 @default.
• W1991026121 countsByYear W19910261212019 @default.
• W1991026121 countsByYear W19910261212021 @default.
• W1991026121 countsByYear W19910261212022 @default.
• W1991026121 crossrefType "journal-article" @default.
• W1991026121 hasAuthorship W1991026121A5002693527 @default.
• W1991026121 hasAuthorship W1991026121A5025569186 @default.
• W1991026121 hasAuthorship W1991026121A5035850380 @default.
• W1991026121 hasAuthorship W1991026121A5047467006 @default.
• W1991026121 hasAuthorship W1991026121A5049245443 @default.
• W1991026121 hasAuthorship W1991026121A5064745020 @default.
• W1991026121 hasAuthorship W1991026121A5072131496 @default.
• W1991026121 hasAuthorship W1991026121A5073475135 @default.
• W1991026121 hasAuthorship W1991026121A5075377112 @default.
• W1991026121 hasAuthorship W1991026121A5086576972 @default.
• W1991026121 hasAuthorship W1991026121A5089260333 @default.
• W1991026121 hasAuthorship W1991026121A5090944717 @default.
• W1991026121 hasConcept C121608353 @default.
• W1991026121 hasConcept C126322002 @default.
• W1991026121 hasConcept C134018914 @default.
• W1991026121 hasConcept C2776235491 @default.
• W1991026121 hasConcept C2777164284 @default.
• W1991026121 hasConcept C2777911890 @default.
• W1991026121 hasConcept C2779279991 @default.
• W1991026121 hasConcept C2779723316 @default.
• W1991026121 hasConcept C2779881493 @default.
• W1991026121 hasConcept C2780192828 @default.
• W1991026121 hasConcept C502942594 @default.
• W1991026121 hasConcept C61367390 @default.

• next