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- W1991027508 abstract "Porous titanium-nickel (PTN) implants represent an alternative to traditional intervertebral fusion cages. Indeed, PTN materials possess interconnecting pores with cell capillarity properties that may promote bone ingrowth and intervertebral fusion without the need for bone grafting. In this study, a PTN intervertebral fusion device was compared to a conventional TiAlV cage packed with autologous bone in a sheep model. The two devices were implanted at two noncontiguous intervertebral lumbar sites for 3, 6, and 12 months. PTN osseointegration showed a time-dependent trend increasing from 21.4% to 37.6% (3-12 months), whereas TiAlV cages remained at the same level of bone ingrowth (22.7%-25.4%; 3-12 months). Furthermore, PTN bone apposition (10.9%-24.2%; 3-12 months) was significantly higher than that of TiAlV implants (1.1%-5.1%; 3-12 months; p < 0.001, ANOVA). Radiological fusion scores increased with postsurgery time regardless of material type, but were consistently superior for PTN (12.5-18.5; 3-12 months) than for TiAlV cages (2.0-15.0; 3-12 months; p < 0.001, ANOVA). Implant materials were not significantly different according to the radiological interbody index based on preoperative disc height: Interbody index began at 132.6% (PTN) and 123.5% (TiAlV) immediately after surgery, then declined to 80.8% (PTN) and 91.0% (TiAlV) after 12 months. Nevertheless, ungrafted PTN constituted an excellent substrate for osteogenic cell integration and represents a new osteoconductive biomaterial with improved fusion characteristics in comparison to conventional TiAlV cages." @default.
- W1991027508 created "2016-06-24" @default.
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- W1991027508 date "2003-01-03" @default.
- W1991027508 modified "2023-10-18" @default.
- W1991027508 title "Porous titanium-nickel for intervertebral fusion in a sheep model: Part 1. Histomorphometric and radiological analysis1" @default.
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- W1991027508 doi "https://doi.org/10.1002/jbm.b.10530" @default.
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