Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991029303> ?p ?o ?g. }
- W1991029303 endingPage "729" @default.
- W1991029303 startingPage "721" @default.
- W1991029303 abstract "In vitro studies revealed serotonin transporter (5-HTT) decline in Parkinson's disease (PD). Yet, few studies investigated thalamic 5-HTT in vivo and its effect on PD heterogeneity. We analyzed thalamic [(123)I]beta-CIT binding (mainly reflecting 5-HTT binding) in 32 drug-naïve PD patients and 13 controls with SPECT. Twenty-six patients were examined twice (17 months apart). Based on UPDRS scores, we identified subgroups of patients with moderate/severe tremor (PD(T)) and without tremor (PD(WT)) at the time of clinical diagnosis. Additionally, depressive symptoms were evaluated using the Beck Depression Inventory (BDI) at baseline. Mean thalamic specific to non-specific [(123)I]beta-CIT binding ratio was lower in patients when compared to controls, and further decreased during follow-up. At baseline, average thalamic ratio was significantly lower in the PD(T) than in the PD(WT) subgroup. No correlation was found between BDI scores and thalamic binding ratios. Our findings show decline of [(123)I]beta-CIT binding to thalamic 5-HTT in PD and its possible contribution to tremor onset." @default.
- W1991029303 created "2016-06-24" @default.
- W1991029303 creator A5017091939 @default.
- W1991029303 creator A5023413872 @default.
- W1991029303 creator A5025574771 @default.
- W1991029303 creator A5028342485 @default.
- W1991029303 creator A5041100881 @default.
- W1991029303 creator A5052133972 @default.
- W1991029303 creator A5053017424 @default.
- W1991029303 creator A5053670767 @default.
- W1991029303 creator A5058966121 @default.
- W1991029303 creator A5063552454 @default.
- W1991029303 date "2008-03-12" @default.
- W1991029303 modified "2023-10-16" @default.
- W1991029303 title "Loss of thalamic serotonin transporters in early drug-naïve Parkinson’s disease patients is associated with tremor: an [123I]β-CIT SPECT study" @default.
- W1991029303 cites W1623913572 @default.
- W1991029303 cites W1649311764 @default.
- W1991029303 cites W1965358782 @default.
- W1991029303 cites W1966448916 @default.
- W1991029303 cites W1968431546 @default.
- W1991029303 cites W1983944942 @default.
- W1991029303 cites W1991529684 @default.
- W1991029303 cites W1994061136 @default.
- W1991029303 cites W1997081993 @default.
- W1991029303 cites W2002431963 @default.
- W1991029303 cites W2002506451 @default.
- W1991029303 cites W2003817082 @default.
- W1991029303 cites W2007510516 @default.
- W1991029303 cites W2008054152 @default.
- W1991029303 cites W2010616666 @default.
- W1991029303 cites W2016071746 @default.
- W1991029303 cites W2023673457 @default.
- W1991029303 cites W2024498737 @default.
- W1991029303 cites W2024642609 @default.
- W1991029303 cites W2027448435 @default.
- W1991029303 cites W2029239144 @default.
- W1991029303 cites W2030970694 @default.
- W1991029303 cites W2041550755 @default.
- W1991029303 cites W2055779291 @default.
- W1991029303 cites W2056145524 @default.
- W1991029303 cites W2057679038 @default.
- W1991029303 cites W2063784421 @default.
- W1991029303 cites W2067302859 @default.
- W1991029303 cites W2070154553 @default.
- W1991029303 cites W2073449985 @default.
- W1991029303 cites W2079857284 @default.
- W1991029303 cites W2084311288 @default.
- W1991029303 cites W2084333768 @default.
- W1991029303 cites W2084691554 @default.
- W1991029303 cites W2087936593 @default.
- W1991029303 cites W2092027166 @default.
- W1991029303 cites W2095857082 @default.
- W1991029303 cites W2108772304 @default.
- W1991029303 cites W2108993083 @default.
- W1991029303 cites W2114177397 @default.
- W1991029303 cites W2139783122 @default.
- W1991029303 cites W2145665803 @default.
- W1991029303 cites W2147730137 @default.
- W1991029303 cites W2149612026 @default.
- W1991029303 cites W2165604870 @default.
- W1991029303 cites W2334150216 @default.
- W1991029303 cites W2396339896 @default.
- W1991029303 cites W2415802915 @default.
- W1991029303 cites W2464687139 @default.
- W1991029303 cites W4230111148 @default.
- W1991029303 cites W4238241060 @default.
- W1991029303 cites W4252938415 @default.
- W1991029303 cites W4366065562 @default.
- W1991029303 doi "https://doi.org/10.1007/s00702-007-0015-2" @default.
- W1991029303 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2440940" @default.
- W1991029303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18335163" @default.
- W1991029303 hasPublicationYear "2008" @default.
- W1991029303 type Work @default.
- W1991029303 sameAs 1991029303 @default.
- W1991029303 citedByCount "50" @default.
- W1991029303 countsByYear W19910293032012 @default.
- W1991029303 countsByYear W19910293032013 @default.
- W1991029303 countsByYear W19910293032014 @default.
- W1991029303 countsByYear W19910293032015 @default.
- W1991029303 countsByYear W19910293032016 @default.
- W1991029303 countsByYear W19910293032017 @default.
- W1991029303 countsByYear W19910293032019 @default.
- W1991029303 countsByYear W19910293032020 @default.
- W1991029303 countsByYear W19910293032021 @default.
- W1991029303 countsByYear W19910293032022 @default.
- W1991029303 countsByYear W19910293032023 @default.
- W1991029303 crossrefType "journal-article" @default.
- W1991029303 hasAuthorship W1991029303A5017091939 @default.
- W1991029303 hasAuthorship W1991029303A5023413872 @default.
- W1991029303 hasAuthorship W1991029303A5025574771 @default.
- W1991029303 hasAuthorship W1991029303A5028342485 @default.
- W1991029303 hasAuthorship W1991029303A5041100881 @default.
- W1991029303 hasAuthorship W1991029303A5052133972 @default.
- W1991029303 hasAuthorship W1991029303A5053017424 @default.
- W1991029303 hasAuthorship W1991029303A5053670767 @default.
- W1991029303 hasAuthorship W1991029303A5058966121 @default.
- W1991029303 hasAuthorship W1991029303A5063552454 @default.
- W1991029303 hasBestOaLocation W19910293031 @default.