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• W1991036161 abstract "Fibroblast migration is directed by gradients of platelet-derived growth factor (PDGF) during wound healing. As in other chemotactic systems, it has been shown recently that localized stimulation of intracellular phosphoinositide (PI) 3-kinase activity and production of 3' PI lipids in the plasma membrane are important events in the signaling of spatially biased motility processes. In turn, 3' PI localization depends on the effective diffusion coefficient, D, and turnover rate constant, k, of these lipids. Here we present a systematic and direct comparison of mathematical model calculations and experimental measurements to estimate the values of the effective 3' PI diffusion coefficient, D, turnover rate constant, k, and other parameters in individual fibroblasts stimulated uniformly with PDGF. In the context of our uniform stimulation model, the values of D and k in each cell were typically estimated within 10-20% or less, and the mean values across all of the cells analyzed were D = 0.37 +/- 0.25 microm2/s and k = 1.18 +/- 0.54 min(-1). In addition, we report that 3' PI turnover is not affected by PDGF receptor signaling in our cells, allowing us to focus our attention on the regulation of 3' PI production as this system is studied further." @default.
• W1991036161 created "2016-06-24" @default.
• W1991036161 creator A5042446847 @default.
• W1991036161 creator A5081447259 @default.
• W1991036161 date "2004-01-01" @default.
• W1991036161 modified "2023-10-12" @default.
• W1991036161 title "Spatial Analysis of 3′ Phosphoinositide Signaling in Living Fibroblasts: II. Parameter Estimates for Individual Cells from Experiments" @default.
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• W1991036161 doi "https://doi.org/10.1016/s0006-3495(04)74138-7" @default.
• W1991036161 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1303829" @default.
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• W1991036161 hasPublicationYear "2004" @default.
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