FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991052557> ?p ?o ?g. }

• W1991052557 endingPage "1052" @default.
• W1991052557 startingPage "1045" @default.
• W1991052557 abstract "Several enzymes with the capacity to degrade glutamate have been suggested as possible neuroprotectants. We initially evaluated the kinetic properties of glutamate pyruvate transaminase (GPT; also known as alanine aminotransferase), glutamine synthetase, and glutamate dehydrogenase under physiologic conditions to degrade neurotoxic concentrations of glutamate. Although all three enzymes initially degraded glutamate rapidly, only GPT was able to reduce toxic (500 microM) levels of glutamate into the physiologic (<20 microM) range. Primary cultures of fetal murine cortical neurons were subjected to paradigms of either exogenous or endogenous glutamate toxicity to evaluate the neuroprotective value of GPT. Neuronal survival after exposure to added glutamate ranging from 100 to 500 microM was improved significantly in the presence of GPT (> or =1 U/ml). Cultures were also exposed to the glutamate transporter inhibitor L-trans-pyrrolidine-2,4-dicarboxylate (PDC), which produces neuronal injury by elevating extracellular glutamate. GPT significantly reduced the toxicity of PDC. This reduction was associated with a reduction in the PDC-dependent rise in the medium concentration of glutamate. These results suggest that enzymatic degradation of glutamate by GPT can be an alternative to glutamate receptor blockade as a strategy to protect neurons from excitotoxic injury." @default.
• W1991052557 created "2016-06-24" @default.
• W1991052557 creator A5004456921 @default.
• W1991052557 creator A5044237308 @default.
• W1991052557 creator A5058412797 @default.
• W1991052557 creator A5060555082 @default.
• W1991052557 date "2002-01-04" @default.
• W1991052557 modified "2023-10-14" @default.
• W1991052557 title "Enzymatic Degradation Protects Neurons from Glutamate Excitotoxicity" @default.
• W1991052557 cites W1530906906 @default.
• W1991052557 cites W1570138648 @default.
• W1991052557 cites W1582272079 @default.
• W1991052557 cites W1600495850 @default.
• W1991052557 cites W1809841703 @default.
• W1991052557 cites W1896952141 @default.
• W1991052557 cites W1957958801 @default.
• W1991052557 cites W1967081763 @default.
• W1991052557 cites W1972175290 @default.
• W1991052557 cites W1975715220 @default.
• W1991052557 cites W1981993146 @default.
• W1991052557 cites W1982888478 @default.
• W1991052557 cites W1986950542 @default.
• W1991052557 cites W1992868992 @default.
• W1991052557 cites W1994907534 @default.
• W1991052557 cites W1997243628 @default.
• W1991052557 cites W1998510465 @default.
• W1991052557 cites W2002173877 @default.
• W1991052557 cites W2003066583 @default.
• W1991052557 cites W2004202588 @default.
• W1991052557 cites W2007514801 @default.
• W1991052557 cites W2012454384 @default.
• W1991052557 cites W2015308817 @default.
• W1991052557 cites W2016575029 @default.
• W1991052557 cites W2019483700 @default.
• W1991052557 cites W2026300560 @default.
• W1991052557 cites W2027824573 @default.
• W1991052557 cites W2029659812 @default.
• W1991052557 cites W2029835882 @default.
• W1991052557 cites W2034541947 @default.
• W1991052557 cites W2035750459 @default.
• W1991052557 cites W2036273748 @default.
• W1991052557 cites W2036291450 @default.
• W1991052557 cites W2037560475 @default.
• W1991052557 cites W2052954167 @default.
• W1991052557 cites W2057359585 @default.
• W1991052557 cites W2062860475 @default.
• W1991052557 cites W2065929873 @default.
• W1991052557 cites W2082969312 @default.
• W1991052557 cites W2089202206 @default.
• W1991052557 cites W2092034907 @default.
• W1991052557 cites W2111102537 @default.
• W1991052557 cites W2114745427 @default.
• W1991052557 cites W2127778297 @default.
• W1991052557 cites W2132949150 @default.
• W1991052557 cites W2136733807 @default.
• W1991052557 cites W2148999943 @default.
• W1991052557 cites W2149497936 @default.
• W1991052557 cites W2152684842 @default.
• W1991052557 cites W2157853053 @default.
• W1991052557 cites W2160228434 @default.
• W1991052557 cites W2273557250 @default.
• W1991052557 cites W4235966908 @default.
• W1991052557 doi "https://doi.org/10.1046/j.1471-4159.2000.0751045.x" @default.
• W1991052557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10936185" @default.
• W1991052557 hasPublicationYear "2002" @default.
• W1991052557 type Work @default.
• W1991052557 sameAs 1991052557 @default.
• W1991052557 citedByCount "58" @default.
• W1991052557 countsByYear W19910525572012 @default.
• W1991052557 countsByYear W19910525572013 @default.
• W1991052557 countsByYear W19910525572015 @default.
• W1991052557 countsByYear W19910525572016 @default.
• W1991052557 countsByYear W19910525572018 @default.
• W1991052557 countsByYear W19910525572019 @default.
• W1991052557 countsByYear W19910525572020 @default.
• W1991052557 countsByYear W19910525572021 @default.
• W1991052557 countsByYear W19910525572022 @default.
• W1991052557 countsByYear W19910525572023 @default.
• W1991052557 crossrefType "journal-article" @default.
• W1991052557 hasAuthorship W1991052557A5004456921 @default.
• W1991052557 hasAuthorship W1991052557A5044237308 @default.
• W1991052557 hasAuthorship W1991052557A5058412797 @default.
• W1991052557 hasAuthorship W1991052557A5060555082 @default.
• W1991052557 hasBestOaLocation W19910525571 @default.
• W1991052557 hasConcept C170493617 @default.
• W1991052557 hasConcept C178790620 @default.
• W1991052557 hasConcept C185592680 @default.
• W1991052557 hasConcept C25498285 @default.
• W1991052557 hasConcept C2777202666 @default.
• W1991052557 hasConcept C2778740566 @default.
• W1991052557 hasConcept C2779289688 @default.
• W1991052557 hasConcept C2779349466 @default.
• W1991052557 hasConcept C2779491297 @default.
• W1991052557 hasConcept C2781012912 @default.
• W1991052557 hasConcept C29730261 @default.
• W1991052557 hasConcept C515207424 @default.
• W1991052557 hasConcept C55493867 @default.
• W1991052557 hasConcept C61174792 @default.

• next