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- W1991069607 abstract "SB-219383 is a naturally occurring antibiotic, which acts by inhibition of tyrosyl tRNA synthetase. Semi-synthetic derivatives of SB-219383 were prepared with the objective of elucidating the key features required for inhibition of tyrosyl tRNA synthetase in order to improve the antibacterial activity. Some ester and amide derivatives as well as monocyclic analogues exhibited sub-nanomolar inhibitory activity against tyrosyl tRNA synthetase." @default.
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- W1991069607 date "2000-01-01" @default.
- W1991069607 modified "2023-10-01" @default.
- W1991069607 title "Synthesis and Activity of Analogues of SB-219383. Novel Potent Inhibitors of Bacterial Tyrosyl tRNA Synthetase." @default.
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- W1991069607 doi "https://doi.org/10.7164/antibiotics.53.1282" @default.
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