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• W1991075691 abstract "In the past 15 years, a novel form of gene regulation has been discovered that is driven by the interaction of short, non-coding RNAs known as microRNAs (miRNAs) with target mRNA transcripts. On the basis of imperfect basepairing with the 3′-untranslated regions (UTRs) of target mRNAs, miRNAs negatively regulate both protein translation and mRNA stability. One of the first miRNAs to be discovered was let-7. First described as a regulator of developmental timing in the nematode, several studies in the past few years have suggested a role for the let-7 miRNA family in tumorigenesis. 1 Viswanathan SR Daley GQ Gregory RI Selective blockade of microRNA processing by Lin28. Science. 2008; 320: 97-100 Crossref PubMed Scopus (1167) Google Scholar , 2 Yu F Yao H Zhu P et al. let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell. 2007; 131: 1109-1123 Summary Full Text Full Text PDF PubMed Scopus (1615) Google Scholar , 3 Iliopoulos D Hirsch HA Struhl K An epigenetic switch involving NF-κB, Lin28, Let-7 microRNA, and IL6 links inflammation to cell transformation. Cell. 2009; 139: 693-706 Summary Full Text Full Text PDF PubMed Scopus (1126) Google Scholar Expression of mature let-7-family miRNAs is suppressed in various cancer types. Moreover, this suppression frequently occurs via overactivation of the LIN28 oncogene, which specifically blocks the processing of let-7 into a functional miRNA. 1 Viswanathan SR Daley GQ Gregory RI Selective blockade of microRNA processing by Lin28. Science. 2008; 320: 97-100 Crossref PubMed Scopus (1167) Google Scholar A 3′-untranslated region KRAS variant and triple-negative breast cancer: a case-control and genetic analysisThe KRAS variant might be a genetic marker for development of triple-negative breast cancer in premenopausal women, and altered gene and miRNA expression signatures should enable molecular and biological stratification of patients with this subgroup of breast cancer. Full-Text PDF MicroRNA therapeutics in preclinical cancer modelsSubstantial progress has been made in the past decade that links the expression of various microRNAs (miRNAs) with cancer. Despite their small sizes at about 22 nucleotides, these endogenous non-coding RNAs have an enormous effect on protein-coding-gene expression, and regulate various cellular events including proliferation, apoptosis, and differentiation. As would be expected, aberrant miRNA expression can have adverse effects on these processes, ultimately contributing to tumour initiation, promotion, and progression. Full-Text PDF" @default.
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• W1991075691 date "2011-04-01" @default.
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• W1991075691 title "KRAS 3′-UTR variants and stratification of breast-cancer risk" @default.
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• W1991075691 doi "https://doi.org/10.1016/s1470-2045(11)70065-1" @default.
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