FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991081808> ?p ?o ?g. }

• W1991081808 endingPage "254" @default.
• W1991081808 startingPage "247" @default.
• W1991081808 abstract "The antihypertensive effects of an angiotensin II antagonist, candesartan cilexetil (TCV-116), and other classes of antihypertensive drugs (including a calcium antagonist, manidipine; a diuretic, hydrochlorothiazide (HCTZ); an α-blocker, prazosin; and a β-blocker, atenolol) administered in combination were examined in spontaneously hypertensive rats by oral administration daily for 2wk. TCV-116 at 1mg/kg lowered the blood pressure by about 50 and 30mmHg, 5 and 24h after dosing, respectively. The blood pressure was slightly lowered by HCTZ at 10mg/kg, but it was synergistically reduced when HCTZ was given in combination with TCV-116. Manidipine at 3mg/kg lowered the blood pressure by about 50 mmHg 1h after administration. When manidipine was given in combination with TCV-116, blood pressure was reduced additively. Prazosin at 1mg/kg lowered the blood pressure by 40 to 50mmHg 1h after dosing. When prazosin was given in combination with TCV-116, the reduction was intensified more than additively, to about 100mmHg. Atenolol at 50mg/kg lowered the blood pressure by 10 to 20 mmHg 5h after dosing. Even when atenolol was administered in combination with TCV-116, the reduction in blood pressure was virtually the same as that observed when TCV-116 was given alone. TCV-116 and HCTZ had no effect on the pulse rate, whereas manidipine and prazosin both increased it, owing to reflex tachycardia, and atenolol decreased it. TCV-116 had no effect on the change in the pulse rate induced by these antihypertensive drugs and no effect on HCTZ-induced diuresis. TCV-116 and HCTZ each caused a significant increase in plasma renin concentration (PRC), and prazosin caused a slight elevation. Manidipine had no effect on the PRC, whereas atenolol reduced it. Given in combination with TCV-116, these antihypertensive drugs had the same effect on the elevated PRC induced by TCV-116 as they did on the basal PRC when administered alone. These results suggest that antihypertensive drugs that cause compensatory activation of the renin-angiotensin system have more marked antihypertensive activity when given in combination with TCV-116, but that there will is no combined effect on the pulse rate. (Hypertens Res 1996; 19: 247-254)" @default.
• W1991081808 created "2016-06-24" @default.
• W1991081808 creator A5012400943 @default.
• W1991081808 creator A5014701262 @default.
• W1991081808 creator A5014798054 @default.
• W1991081808 creator A5069546436 @default.
• W1991081808 creator A5083688123 @default.
• W1991081808 creator A5087936762 @default.
• W1991081808 date "1996-01-01" @default.
• W1991081808 modified "2023-10-18" @default.
• W1991081808 title "Combined Effects of the Angiotensin II Antagonist Candesartan Cilexetil(TCV-116) and Other Classes of Antihypertensive Drugs in Spontaneously Hypertensive Rats." @default.
• W1991081808 cites W1488521817 @default.
• W1991081808 cites W1891400372 @default.
• W1991081808 cites W1896649133 @default.
• W1991081808 cites W1971083741 @default.
• W1991081808 cites W1973920411 @default.
• W1991081808 cites W1979605016 @default.
• W1991081808 cites W1990377157 @default.
• W1991081808 cites W2005139263 @default.
• W1991081808 cites W2006305864 @default.
• W1991081808 cites W2008363767 @default.
• W1991081808 cites W2014197056 @default.
• W1991081808 cites W2014209213 @default.
• W1991081808 cites W2023967992 @default.
• W1991081808 cites W2026885101 @default.
• W1991081808 cites W2028869082 @default.
• W1991081808 cites W2031315917 @default.
• W1991081808 cites W2041462266 @default.
• W1991081808 cites W2063722503 @default.
• W1991081808 cites W2065216546 @default.
• W1991081808 cites W2092764178 @default.
• W1991081808 cites W2105746151 @default.
• W1991081808 cites W2138732272 @default.
• W1991081808 cites W2186883299 @default.
• W1991081808 cites W2232290564 @default.
• W1991081808 cites W2261416373 @default.
• W1991081808 cites W2289785680 @default.
• W1991081808 cites W2315103522 @default.
• W1991081808 cites W2516430170 @default.
• W1991081808 doi "https://doi.org/10.1291/hypres.19.247" @default.
• W1991081808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8986455" @default.
• W1991081808 hasPublicationYear "1996" @default.
• W1991081808 type Work @default.
• W1991081808 sameAs 1991081808 @default.
• W1991081808 citedByCount "15" @default.
• W1991081808 countsByYear W19910818082014 @default.
• W1991081808 countsByYear W19910818082016 @default.
• W1991081808 countsByYear W19910818082018 @default.
• W1991081808 countsByYear W19910818082021 @default.
• W1991081808 crossrefType "journal-article" @default.
• W1991081808 hasAuthorship W1991081808A5012400943 @default.
• W1991081808 hasAuthorship W1991081808A5014701262 @default.
• W1991081808 hasAuthorship W1991081808A5014798054 @default.
• W1991081808 hasAuthorship W1991081808A5069546436 @default.
• W1991081808 hasAuthorship W1991081808A5083688123 @default.
• W1991081808 hasAuthorship W1991081808A5087936762 @default.
• W1991081808 hasBestOaLocation W19910818081 @default.
• W1991081808 hasConcept C126322002 @default.
• W1991081808 hasConcept C134018914 @default.
• W1991081808 hasConcept C170493617 @default.
• W1991081808 hasConcept C2776525901 @default.
• W1991081808 hasConcept C2776885963 @default.
• W1991081808 hasConcept C2780036600 @default.
• W1991081808 hasConcept C2780361556 @default.
• W1991081808 hasConcept C2780648677 @default.
• W1991081808 hasConcept C2908929049 @default.
• W1991081808 hasConcept C71924100 @default.
• W1991081808 hasConcept C84393581 @default.
• W1991081808 hasConcept C98274493 @default.
• W1991081808 hasConceptScore W1991081808C126322002 @default.
• W1991081808 hasConceptScore W1991081808C134018914 @default.
• W1991081808 hasConceptScore W1991081808C170493617 @default.
• W1991081808 hasConceptScore W1991081808C2776525901 @default.
• W1991081808 hasConceptScore W1991081808C2776885963 @default.
• W1991081808 hasConceptScore W1991081808C2780036600 @default.
• W1991081808 hasConceptScore W1991081808C2780361556 @default.
• W1991081808 hasConceptScore W1991081808C2780648677 @default.
• W1991081808 hasConceptScore W1991081808C2908929049 @default.
• W1991081808 hasConceptScore W1991081808C71924100 @default.
• W1991081808 hasConceptScore W1991081808C84393581 @default.
• W1991081808 hasConceptScore W1991081808C98274493 @default.
• W1991081808 hasIssue "4" @default.
• W1991081808 hasLocation W19910818081 @default.
• W1991081808 hasLocation W19910818082 @default.
• W1991081808 hasOpenAccess W1991081808 @default.
• W1991081808 hasPrimaryLocation W19910818081 @default.
• W1991081808 hasRelatedWork W1643020507 @default.
• W1991081808 hasRelatedWork W177762941 @default.
• W1991081808 hasRelatedWork W2011930145 @default.
• W1991081808 hasRelatedWork W2028008214 @default.
• W1991081808 hasRelatedWork W2055873472 @default.
• W1991081808 hasRelatedWork W2074951346 @default.
• W1991081808 hasRelatedWork W2151865548 @default.
• W1991081808 hasRelatedWork W2241925007 @default.
• W1991081808 hasRelatedWork W2363151701 @default.
• W1991081808 hasRelatedWork W2392044478 @default.
• W1991081808 hasVolume "19" @default.
• W1991081808 isParatext "false" @default.

• next