FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991083963> ?p ?o ?g. }

• W1991083963 endingPage "440" @default.
• W1991083963 startingPage "436" @default.
• W1991083963 abstract "Evidence is accumulating that the illness and pathology observed in malaria are not caused directly by parasite products, but by normal components of the immune response, mainly monokines such as tumor necrosis factor (TNF), produced in excess. These mediators are released from the host's monocytes and macrophages, apparently in response to stimulation by parasite products. Recombinant TNF, if injected into a range of animal species or into tumour patients, is demonstrably toxic, giving rise to changes typical of acute malaria, and several groups have detected circulating TNF in serum from patients acutely ill with malaria. The short serum clearance time of TNF and TNF tolerance have to be considered when interpreting such data. Current studies indicate that some malarial antigens, in the absence of lipopolysaccharide, can trigger release of TNF. This and other monokines could contribute to cerebral malaria in at least 2 ways: by increasing thrombospondin secretion, and hence favouring local sequestration of knob-bearing parasitized red cells, and, as has been demonstrated in clinical trials in tumour patients, by causing neurological symptoms directly. In addition, it seems that TNF does not act alone, but as part of an interdependent synergizing network of polypeptide mediators. These evidently act together to induce secretion of other cell products, such as platelet-activating factor, prostaglandins, reactive oxygen species and procoagulant activity, that actually cause illness, biochemical change and tissue damage. Understanding these processes should lead to a range of new therapeutic interventions." @default.
• W1991083963 created "2016-06-24" @default.
• W1991083963 creator A5032488465 @default.
• W1991083963 creator A5076752790 @default.
• W1991083963 creator A5084713074 @default.
• W1991083963 date "1989-07-01" @default.
• W1991083963 modified "2023-10-16" @default.
• W1991083963 title "Roles of tumour necrosis factor in the illness and pathology of malaria" @default.
• W1991083963 cites W1538118659 @default.
• W1991083963 cites W1710867374 @default.
• W1991083963 cites W1832124212 @default.
• W1991083963 cites W1926917528 @default.
• W1991083963 cites W1964911589 @default.
• W1991083963 cites W1970925929 @default.
• W1991083963 cites W1971473545 @default.
• W1991083963 cites W1977130245 @default.
• W1991083963 cites W1999246265 @default.
• W1991083963 cites W2001541164 @default.
• W1991083963 cites W2011291552 @default.
• W1991083963 cites W2013114215 @default.
• W1991083963 cites W2024871040 @default.
• W1991083963 cites W2033136036 @default.
• W1991083963 cites W2033684442 @default.
• W1991083963 cites W2037046526 @default.
• W1991083963 cites W2038434279 @default.
• W1991083963 cites W2046358093 @default.
• W1991083963 cites W2047183254 @default.
• W1991083963 cites W2058776294 @default.
• W1991083963 cites W2074535583 @default.
• W1991083963 cites W2076970414 @default.
• W1991083963 cites W2082162853 @default.
• W1991083963 cites W2085077927 @default.
• W1991083963 cites W2117257649 @default.
• W1991083963 cites W2166542918 @default.
• W1991083963 cites W2417960111 @default.
• W1991083963 cites W268359948 @default.
• W1991083963 doi "https://doi.org/10.1016/0035-9203(89)90240-x" @default.
• W1991083963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2694475" @default.
• W1991083963 hasPublicationYear "1989" @default.
• W1991083963 type Work @default.
• W1991083963 sameAs 1991083963 @default.
• W1991083963 citedByCount "122" @default.
• W1991083963 countsByYear W19910839632012 @default.
• W1991083963 countsByYear W19910839632013 @default.
• W1991083963 countsByYear W19910839632014 @default.
• W1991083963 countsByYear W19910839632015 @default.
• W1991083963 countsByYear W19910839632016 @default.
• W1991083963 countsByYear W19910839632017 @default.
• W1991083963 countsByYear W19910839632018 @default.
• W1991083963 countsByYear W19910839632021 @default.
• W1991083963 countsByYear W19910839632022 @default.
• W1991083963 crossrefType "journal-article" @default.
• W1991083963 hasAuthorship W1991083963A5032488465 @default.
• W1991083963 hasAuthorship W1991083963A5076752790 @default.
• W1991083963 hasAuthorship W1991083963A5084713074 @default.
• W1991083963 hasConcept C142724271 @default.
• W1991083963 hasConcept C17991360 @default.
• W1991083963 hasConcept C203014093 @default.
• W1991083963 hasConcept C2776914184 @default.
• W1991083963 hasConcept C2778048844 @default.
• W1991083963 hasConcept C2778371730 @default.
• W1991083963 hasConcept C2778754761 @default.
• W1991083963 hasConcept C2908793570 @default.
• W1991083963 hasConcept C49382859 @default.
• W1991083963 hasConcept C503630168 @default.
• W1991083963 hasConcept C71924100 @default.
• W1991083963 hasConcept C86803240 @default.
• W1991083963 hasConcept C8891405 @default.
• W1991083963 hasConceptScore W1991083963C142724271 @default.
• W1991083963 hasConceptScore W1991083963C17991360 @default.
• W1991083963 hasConceptScore W1991083963C203014093 @default.
• W1991083963 hasConceptScore W1991083963C2776914184 @default.
• W1991083963 hasConceptScore W1991083963C2778048844 @default.
• W1991083963 hasConceptScore W1991083963C2778371730 @default.
• W1991083963 hasConceptScore W1991083963C2778754761 @default.
• W1991083963 hasConceptScore W1991083963C2908793570 @default.
• W1991083963 hasConceptScore W1991083963C49382859 @default.
• W1991083963 hasConceptScore W1991083963C503630168 @default.
• W1991083963 hasConceptScore W1991083963C71924100 @default.
• W1991083963 hasConceptScore W1991083963C86803240 @default.
• W1991083963 hasConceptScore W1991083963C8891405 @default.
• W1991083963 hasIssue "4" @default.
• W1991083963 hasLocation W19910839631 @default.
• W1991083963 hasLocation W19910839632 @default.
• W1991083963 hasOpenAccess W1991083963 @default.
• W1991083963 hasPrimaryLocation W19910839631 @default.
• W1991083963 hasRelatedWork W1983582201 @default.
• W1991083963 hasRelatedWork W2039976430 @default.
• W1991083963 hasRelatedWork W2049659301 @default.
• W1991083963 hasRelatedWork W2077977733 @default.
• W1991083963 hasRelatedWork W2100828460 @default.
• W1991083963 hasRelatedWork W2131503133 @default.
• W1991083963 hasRelatedWork W2403302911 @default.
• W1991083963 hasRelatedWork W4300951857 @default.
• W1991083963 hasRelatedWork W4307427571 @default.
• W1991083963 hasRelatedWork W4386073946 @default.
• W1991083963 hasVolume "83" @default.
• W1991083963 isParatext "false" @default.

• next