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• W1991105234 abstract "This study was performed to evaluate how the loss of a guanine base affects the structure and stability of the three-tetrad G-quadruplex of 5'-dG(3)(TTAG(3))(3), the basic quadruplex-forming unit of the human telomere DNA. None of the 12 possible abasic sites hindered the formation of quadruplexes, but all reduced the thermodynamic stability of the parent quadruplex in both NaCl and KCl. The base loss did not change the Na(+)-stabilized intramolecular antiparallel architecture, based on CD spectra, but held up the conformational change induced in dG(3)(TTAG(3))(3) in physiological concentration of KCl. The reduced stability and the inhibited conformational transitions observed here in vitro for the first time may predict that unrepaired abasic sites in G-quadruplexes could lead to changes in the chromosome's terminal protection in vivo." @default.
• W1991105234 created "2016-06-24" @default.
• W1991105234 creator A5037858149 @default.
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• W1991105234 date "2010-08-01" @default.
• W1991105234 modified "2023-10-15" @default.
• W1991105234 title "Quadruplexes of human telomere dG3(TTAG3)3 sequences containing guanine abasic sites" @default.
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• W1991105234 doi "https://doi.org/10.1016/j.bbrc.2010.07.055" @default.
• W1991105234 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20643102" @default.
• W1991105234 hasPublicationYear "2010" @default.
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