Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991105889> ?p ?o ?g. }
- W1991105889 endingPage "308" @default.
- W1991105889 startingPage "300" @default.
- W1991105889 abstract "This work reports on the formation of a carrier-in-carrier device for the systemic delivery and targeting of hydrophobic drugs mediated by micelle-loaded mesenchymal stromal cells (MSCs) (carrier-in-carrier) to be administered by intravenous injection. The innate ability of MSCs to reach injured tissues such as the central nervous system or other damaged tissues, is the key for the second order delivery and first order targeting. Inulin-d-alfa-tocopherol succinate micelles (INVITE M) are able to incorporate highly hydrophobic drugs and, due to their dimensions (≈7 nm diameter), to penetrate the cell membrane easily and quickly. This study demonstrates that the curcumin loaded micelles (INVITE MC), sterilized by filtration, reached the maximum loading in MSCs in few minutes and that the loading was concentration-dependent. When “naked” curcumin was used, an evident cytotoxicity on MSCs was detected, while INVITE micelles protected them from this effect. Moreover, MSCs loaded with INVITE MC are able to release the entrapped drug. This study strongly supports the feasibility of the carrier-in-carrier approach for the therapy of selected diseases, i.e., this innovative drug delivery system will be proposed for the treatment of the amyotrophic lateral sclerosis (ALS)." @default.
- W1991105889 created "2016-06-24" @default.
- W1991105889 creator A5000040467 @default.
- W1991105889 creator A5008122742 @default.
- W1991105889 creator A5008154639 @default.
- W1991105889 creator A5012039400 @default.
- W1991105889 creator A5023628950 @default.
- W1991105889 creator A5027131517 @default.
- W1991105889 creator A5077332342 @default.
- W1991105889 creator A5078938938 @default.
- W1991105889 creator A5079241742 @default.
- W1991105889 creator A5081720047 @default.
- W1991105889 creator A5084789414 @default.
- W1991105889 creator A5089242141 @default.
- W1991105889 date "2015-01-01" @default.
- W1991105889 modified "2023-10-16" @default.
- W1991105889 title "Mesenchymal stromal cells loading curcumin-INVITE-micelles: A drug delivery system for neurodegenerative diseases" @default.
- W1991105889 cites W1512256229 @default.
- W1991105889 cites W1564553363 @default.
- W1991105889 cites W1920534265 @default.
- W1991105889 cites W1966045502 @default.
- W1991105889 cites W1966100398 @default.
- W1991105889 cites W1968803367 @default.
- W1991105889 cites W1976194786 @default.
- W1991105889 cites W1978274834 @default.
- W1991105889 cites W1978350090 @default.
- W1991105889 cites W1983179218 @default.
- W1991105889 cites W1983342786 @default.
- W1991105889 cites W1984179022 @default.
- W1991105889 cites W1988435134 @default.
- W1991105889 cites W1990950572 @default.
- W1991105889 cites W1999360673 @default.
- W1991105889 cites W2000630485 @default.
- W1991105889 cites W2017351406 @default.
- W1991105889 cites W2020085931 @default.
- W1991105889 cites W2021222438 @default.
- W1991105889 cites W2023956684 @default.
- W1991105889 cites W2024679196 @default.
- W1991105889 cites W2025371271 @default.
- W1991105889 cites W2025751503 @default.
- W1991105889 cites W2033960117 @default.
- W1991105889 cites W2037602102 @default.
- W1991105889 cites W2038434857 @default.
- W1991105889 cites W2045174723 @default.
- W1991105889 cites W2046413934 @default.
- W1991105889 cites W2046784389 @default.
- W1991105889 cites W2047646153 @default.
- W1991105889 cites W2059520952 @default.
- W1991105889 cites W2063825051 @default.
- W1991105889 cites W2064659525 @default.
- W1991105889 cites W2067553824 @default.
- W1991105889 cites W2072175441 @default.
- W1991105889 cites W2082511916 @default.
- W1991105889 cites W2085626804 @default.
- W1991105889 cites W2088970027 @default.
- W1991105889 cites W2131357228 @default.
- W1991105889 cites W2134578689 @default.
- W1991105889 cites W2137571679 @default.
- W1991105889 cites W2146022283 @default.
- W1991105889 cites W2155137515 @default.
- W1991105889 cites W2163119148 @default.
- W1991105889 cites W2166042133 @default.
- W1991105889 cites W2324365382 @default.
- W1991105889 cites W4253288154 @default.
- W1991105889 doi "https://doi.org/10.1016/j.colsurfb.2014.11.034" @default.
- W1991105889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25524221" @default.
- W1991105889 hasPublicationYear "2015" @default.
- W1991105889 type Work @default.
- W1991105889 sameAs 1991105889 @default.
- W1991105889 citedByCount "56" @default.
- W1991105889 countsByYear W19911058892015 @default.
- W1991105889 countsByYear W19911058892016 @default.
- W1991105889 countsByYear W19911058892017 @default.
- W1991105889 countsByYear W19911058892018 @default.
- W1991105889 countsByYear W19911058892019 @default.
- W1991105889 countsByYear W19911058892020 @default.
- W1991105889 countsByYear W19911058892021 @default.
- W1991105889 countsByYear W19911058892022 @default.
- W1991105889 countsByYear W19911058892023 @default.
- W1991105889 crossrefType "journal-article" @default.
- W1991105889 hasAuthorship W1991105889A5000040467 @default.
- W1991105889 hasAuthorship W1991105889A5008122742 @default.
- W1991105889 hasAuthorship W1991105889A5008154639 @default.
- W1991105889 hasAuthorship W1991105889A5012039400 @default.
- W1991105889 hasAuthorship W1991105889A5023628950 @default.
- W1991105889 hasAuthorship W1991105889A5027131517 @default.
- W1991105889 hasAuthorship W1991105889A5077332342 @default.
- W1991105889 hasAuthorship W1991105889A5078938938 @default.
- W1991105889 hasAuthorship W1991105889A5079241742 @default.
- W1991105889 hasAuthorship W1991105889A5081720047 @default.
- W1991105889 hasAuthorship W1991105889A5084789414 @default.
- W1991105889 hasAuthorship W1991105889A5089242141 @default.
- W1991105889 hasConcept C109316439 @default.
- W1991105889 hasConcept C11268172 @default.
- W1991105889 hasConcept C13245373 @default.
- W1991105889 hasConcept C136229726 @default.
- W1991105889 hasConcept C142724271 @default.
- W1991105889 hasConcept C147789679 @default.