FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991106842> ?p ?o ?g. }

• W1991106842 endingPage "686" @default.
• W1991106842 startingPage "677" @default.
• W1991106842 abstract "Mechanisms of excitotoxic degeneration of retinal ganglion cells (RGCs) remain controversial, due to the lack of suitable in vitro experimental systems for evaluation of RGC death. In this study, we investigated acute excitotoxicity in RGCs using eyecup preparations obtained from adult rats, with special reference to ionic dependence of N-methyl-D-aspartate (NMDA) and kainate toxicity. Retrograde labeling of RGCs with a fluorescent tracer diamidino yellow, combined with labeling of dead cells by propidium iodide, enabled us to discriminate dead RGCs from other cells in the ganglion cell layer. Exposure of eyecups to NMDA or kainate for 30min followed by 6h post-incubation caused cell death in a subpopulation of RGCs as well as other (presumably displaced amacrine) cells. RGCs in the peripheral area of the retina were less sensitive to NMDA toxicity than those in the central area. Death of RGCs and other retinal cells by NMDA or kainate was largely abolished by substitution of extracellular Cl(-), whereas chelation of extracellular Ca(2+) did not inhibit NMDA or kainate toxicity in RGCs. Strychnine but not bicuculline partially inhibited NMDA-induced RGC death, although these drugs were not effective against kainate-induced RGC death. On the other hand, niflumic acid, a Cl(-) channel blocker, markedly inhibited RGC death induced by kainate as well as by NMDA. These results underscore the important role of Cl(-) in acute excitotoxicity in adult rat RGCs." @default.
• W1991106842 created "2016-06-24" @default.
• W1991106842 creator A5022871013 @default.
• W1991106842 creator A5048153044 @default.
• W1991106842 creator A5054041519 @default.
• W1991106842 creator A5059452732 @default.
• W1991106842 creator A5089074853 @default.
• W1991106842 date "2008-10-01" @default.
• W1991106842 modified "2023-09-26" @default.
• W1991106842 title "Chloride-dependent acute excitotoxicity in adult rat retinal ganglion cells" @default.
• W1991106842 cites W1591728700 @default.
• W1991106842 cites W1897205131 @default.
• W1991106842 cites W1910864442 @default.
• W1991106842 cites W1936849452 @default.
• W1991106842 cites W1964255678 @default.
• W1991106842 cites W1964842209 @default.
• W1991106842 cites W1966217447 @default.
• W1991106842 cites W1968144200 @default.
• W1991106842 cites W1987961317 @default.
• W1991106842 cites W1997366340 @default.
• W1991106842 cites W2008124762 @default.
• W1991106842 cites W2008378754 @default.
• W1991106842 cites W2011270545 @default.
• W1991106842 cites W2024405068 @default.
• W1991106842 cites W2028476182 @default.
• W1991106842 cites W2029693875 @default.
• W1991106842 cites W2045248116 @default.
• W1991106842 cites W2049760844 @default.
• W1991106842 cites W2051395367 @default.
• W1991106842 cites W2062066883 @default.
• W1991106842 cites W2067675217 @default.
• W1991106842 cites W2076176473 @default.
• W1991106842 cites W2079713083 @default.
• W1991106842 cites W2090093046 @default.
• W1991106842 cites W2090396101 @default.
• W1991106842 cites W2098210918 @default.
• W1991106842 cites W2107967179 @default.
• W1991106842 cites W2118756235 @default.
• W1991106842 cites W2121429522 @default.
• W1991106842 cites W2135426025 @default.
• W1991106842 cites W2146082930 @default.
• W1991106842 cites W2147917838 @default.
• W1991106842 cites W2290010678 @default.
• W1991106842 doi "https://doi.org/10.1016/j.neuropharm.2008.06.006" @default.
• W1991106842 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18586043" @default.
• W1991106842 hasPublicationYear "2008" @default.
• W1991106842 type Work @default.
• W1991106842 sameAs 1991106842 @default.
• W1991106842 citedByCount "9" @default.
• W1991106842 countsByYear W19911068422012 @default.
• W1991106842 countsByYear W19911068422015 @default.
• W1991106842 countsByYear W19911068422017 @default.
• W1991106842 countsByYear W19911068422019 @default.
• W1991106842 countsByYear W19911068422021 @default.
• W1991106842 crossrefType "journal-article" @default.
• W1991106842 hasAuthorship W1991106842A5022871013 @default.
• W1991106842 hasAuthorship W1991106842A5048153044 @default.
• W1991106842 hasAuthorship W1991106842A5054041519 @default.
• W1991106842 hasAuthorship W1991106842A5059452732 @default.
• W1991106842 hasAuthorship W1991106842A5089074853 @default.
• W1991106842 hasConcept C160268369 @default.
• W1991106842 hasConcept C169760540 @default.
• W1991106842 hasConcept C170493617 @default.
• W1991106842 hasConcept C185592680 @default.
• W1991106842 hasConcept C189184402 @default.
• W1991106842 hasConcept C190283241 @default.
• W1991106842 hasConcept C2776108384 @default.
• W1991106842 hasConcept C2777093970 @default.
• W1991106842 hasConcept C2777624874 @default.
• W1991106842 hasConcept C2781012912 @default.
• W1991106842 hasConcept C31573885 @default.
• W1991106842 hasConcept C55493867 @default.
• W1991106842 hasConcept C61174792 @default.
• W1991106842 hasConcept C67018056 @default.
• W1991106842 hasConcept C86803240 @default.
• W1991106842 hasConcept C95444343 @default.
• W1991106842 hasConcept C98274493 @default.
• W1991106842 hasConceptScore W1991106842C160268369 @default.
• W1991106842 hasConceptScore W1991106842C169760540 @default.
• W1991106842 hasConceptScore W1991106842C170493617 @default.
• W1991106842 hasConceptScore W1991106842C185592680 @default.
• W1991106842 hasConceptScore W1991106842C189184402 @default.
• W1991106842 hasConceptScore W1991106842C190283241 @default.
• W1991106842 hasConceptScore W1991106842C2776108384 @default.
• W1991106842 hasConceptScore W1991106842C2777093970 @default.
• W1991106842 hasConceptScore W1991106842C2777624874 @default.
• W1991106842 hasConceptScore W1991106842C2781012912 @default.
• W1991106842 hasConceptScore W1991106842C31573885 @default.
• W1991106842 hasConceptScore W1991106842C55493867 @default.
• W1991106842 hasConceptScore W1991106842C61174792 @default.
• W1991106842 hasConceptScore W1991106842C67018056 @default.
• W1991106842 hasConceptScore W1991106842C86803240 @default.
• W1991106842 hasConceptScore W1991106842C95444343 @default.
• W1991106842 hasConceptScore W1991106842C98274493 @default.
• W1991106842 hasIssue "5" @default.
• W1991106842 hasLocation W19911068421 @default.
• W1991106842 hasLocation W19911068422 @default.
• W1991106842 hasOpenAccess W1991106842 @default.

• next