Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991106926> ?p ?o ?g. }
- W1991106926 endingPage "295" @default.
- W1991106926 startingPage "286" @default.
- W1991106926 abstract "The de novo design of αtα, a helical hairpin peptide, is described. αtα (α-helix/turn/α-helix) was developed to provide a model system for protein folding at the level of secondary structure association and stabilization. According to the prevailing models of protein folding, the second step in the folding process is the association and stabilization of secondary structural elements or microdomains. A brief description of the design, along with CD and NMR evidence confirming the conformation of the peptide in solution, has been published (Fezoui Y, Weaver DL, Osterhout JJ, 1994, Proc Natl Acad Sci USA 91:3675–3679). The present work includes a full description of the design process, including the trade-offs that were made during the development of the peptide, a discussion of recent experimental results that were not available at the time of the original design, indications of areas where, in retrospect, the design might have been done differently, and a discussion of how the present work fits into the field of de novo protein design." @default.
- W1991106926 created "2016-06-24" @default.
- W1991106926 creator A5059374607 @default.
- W1991106926 creator A5067725937 @default.
- W1991106926 creator A5079543413 @default.
- W1991106926 date "2008-12-31" @default.
- W1991106926 modified "2023-10-15" @default.
- W1991106926 title "Strategies and rationales for the de novo design of a helical hairpin peptide" @default.
- W1991106926 cites W1501938911 @default.
- W1991106926 cites W1544623810 @default.
- W1991106926 cites W1549731635 @default.
- W1991106926 cites W1550839873 @default.
- W1991106926 cites W1563988826 @default.
- W1991106926 cites W1574312817 @default.
- W1991106926 cites W184140934 @default.
- W1991106926 cites W1965243248 @default.
- W1991106926 cites W1968673134 @default.
- W1991106926 cites W1969216144 @default.
- W1991106926 cites W1970492002 @default.
- W1991106926 cites W1973566939 @default.
- W1991106926 cites W1974027664 @default.
- W1991106926 cites W1974180071 @default.
- W1991106926 cites W1975511017 @default.
- W1991106926 cites W1976271045 @default.
- W1991106926 cites W1980581336 @default.
- W1991106926 cites W1984685683 @default.
- W1991106926 cites W1984723993 @default.
- W1991106926 cites W1987630197 @default.
- W1991106926 cites W1989504189 @default.
- W1991106926 cites W1998084031 @default.
- W1991106926 cites W1998347411 @default.
- W1991106926 cites W1999306340 @default.
- W1991106926 cites W2000889585 @default.
- W1991106926 cites W2001146344 @default.
- W1991106926 cites W2001350069 @default.
- W1991106926 cites W2005145089 @default.
- W1991106926 cites W2005393972 @default.
- W1991106926 cites W2011273569 @default.
- W1991106926 cites W2012716149 @default.
- W1991106926 cites W2014059004 @default.
- W1991106926 cites W2014853910 @default.
- W1991106926 cites W2015561631 @default.
- W1991106926 cites W2019137326 @default.
- W1991106926 cites W2024239863 @default.
- W1991106926 cites W2024368431 @default.
- W1991106926 cites W2026506773 @default.
- W1991106926 cites W2040407044 @default.
- W1991106926 cites W2042252336 @default.
- W1991106926 cites W2044328480 @default.
- W1991106926 cites W2045439785 @default.
- W1991106926 cites W2046073833 @default.
- W1991106926 cites W2053621664 @default.
- W1991106926 cites W2055290772 @default.
- W1991106926 cites W2056770911 @default.
- W1991106926 cites W2056972016 @default.
- W1991106926 cites W2057481603 @default.
- W1991106926 cites W2063329377 @default.
- W1991106926 cites W2065089700 @default.
- W1991106926 cites W2067323731 @default.
- W1991106926 cites W2072628378 @default.
- W1991106926 cites W2076949662 @default.
- W1991106926 cites W2078948535 @default.
- W1991106926 cites W2080686432 @default.
- W1991106926 cites W2081359387 @default.
- W1991106926 cites W2087082736 @default.
- W1991106926 cites W2089958448 @default.
- W1991106926 cites W2093309462 @default.
- W1991106926 cites W2093916503 @default.
- W1991106926 cites W2094604448 @default.
- W1991106926 cites W2094852043 @default.
- W1991106926 cites W2103692741 @default.
- W1991106926 cites W2107276905 @default.
- W1991106926 cites W2107392414 @default.
- W1991106926 cites W2115553515 @default.
- W1991106926 cites W2119825965 @default.
- W1991106926 cites W2128954946 @default.
- W1991106926 cites W2129388900 @default.
- W1991106926 cites W2130904570 @default.
- W1991106926 cites W2140040671 @default.
- W1991106926 cites W2154712137 @default.
- W1991106926 cites W2156686820 @default.
- W1991106926 cites W2162659597 @default.
- W1991106926 cites W2162929118 @default.
- W1991106926 cites W2165499430 @default.
- W1991106926 cites W2170120749 @default.
- W1991106926 cites W2313275058 @default.
- W1991106926 cites W2625908 @default.
- W1991106926 cites W295484251 @default.
- W1991106926 cites W3021991233 @default.
- W1991106926 doi "https://doi.org/10.1002/pro.5560040215" @default.
- W1991106926 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2143057" @default.
- W1991106926 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7757017" @default.
- W1991106926 hasPublicationYear "2008" @default.
- W1991106926 type Work @default.
- W1991106926 sameAs 1991106926 @default.
- W1991106926 citedByCount "25" @default.
- W1991106926 countsByYear W19911069262015 @default.
- W1991106926 countsByYear W19911069262020 @default.