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- W1991110326 abstract "A series of multivalent dendrons containing a bioactive osteogenic growth peptide (OGP) domain and surface-binding catechol domains were obtained through solid phase synthesis, and their binding affinity to hydroxyapatite, TiO2, ZrO2, CeO2, Fe3O4 and gold was characterized using a quartz crystal microbalance with dissipation (QCM-d). Using the distinct difference in binding affinity of the bioconjugate to the metal oxides, TiO2-coated glass slides were selectively patterned with bioactive peptides. Cell culture studies demonstrated the bioavailability of the OGP and that OGP remained on the surface for at least 2 weeks under in vitro cell culture conditions. Bone sialoprotein (BSP) and osteocalcein (OCN) markers were upregulated 3-fold and 60-fold, respectively, relative to controls at 21 days. Similarly, 3-fold more calcium was deposited using the OGP tethered dendron compared to TiO2. These catechol-bearing dendrons provide a fast and efficient method to functionalize a wide range of inorganic materials with bioactive peptides and have the potential to be used in coating orthopaedic implants and fixation devices." @default.
- W1991110326 created "2016-06-24" @default.
- W1991110326 creator A5010338875 @default.
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- W1991110326 date "2014-11-07" @default.
- W1991110326 modified "2023-10-18" @default.
- W1991110326 title "Bioactive Surface Modification of Metal Oxides via Catechol-Bearing Modular Peptides: Multivalent-Binding, Surface Retention, and Peptide Bioactivity" @default.
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- W1991110326 doi "https://doi.org/10.1021/ja508946h" @default.
- W1991110326 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25343707" @default.
- W1991110326 hasPublicationYear "2014" @default.
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