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• W1991120527 abstract "Summary Interleukin (IL)-6 is a pleiotropic cytokine, produced by different cells. There is accumulating evidence that IL-6 promoter polymorphisms impact substantially on various diseases and we identified kidney transplant recipients carrying the IL-6 GGG/GGG −597/−572/−174genotype to have superior graft survival. To prove a functional impact on gene expression, we analysed systematically IL-6 production in healthy individuals with respect to the IL-6 −597/−572/−174genotype. IL-6 was determined in 100 healthy blood donors at protein and mRNA levels upon specific stimulation in monocytes and T lymphocytes under whole blood conditions. GGG/GGG individuals showed a lower IL-6 secretion upon lipopolysaccharide (LPS)-stimulation versus all others (P = 0·039). This link was even stronger when −597 and −174GG genotypes were reanalysed separately (P = 0·008, P = 0·017). However, we found neither a difference at the mRNA level or percentage of CD14+ cells nor after T cell stimulation. We found evidence for the IL-6 −597/−572/−174genotype to affect IL-6 synthesis, i.e. lower levels of IL-6 protein upon LPS-stimulation in GGG/GGG individuals. Further studies are needed in kidney transplant recipients to investigate the potential link between the GGG/GGG genotype and graft survival. In line with this, determination of the genetic risk profiles might be promising to improve the transplant outcome in the individual patient." @default.
• W1991120527 created "2016-06-24" @default.
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• W1991120527 date "2006-11-29" @default.
• W1991120527 modified "2023-09-24" @default.
• W1991120527 title "The impact of interleukin-6 promoter −597/−572/−174genotype on interleukin-6 production after lipopolysaccharide stimulation" @default.
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• W1991120527 doi "https://doi.org/10.1111/j.1365-2249.2006.03273.x" @default.
• W1991120527 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1810465" @default.
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