FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991129150> ?p ?o ?g. }

• W1991129150 endingPage "e23981" @default.
• W1991129150 startingPage "e23981" @default.
• W1991129150 abstract "Targeted gene correction employs a site-specific DNA lesion to promote homologous recombination that eliminates mutation in a disease gene of interest. The double-strand break typically used to initiate correction can also result in genomic instability if deleterious repair occurs rather than gene correction, possibly compromising the safety of targeted gene correction. Here we show that single-strand breaks (nicks) and double-strand breaks both promote efficient gene correction. However, breaks promote high levels of inadvertent but heritable genomic alterations both locally and elsewhere in the genome, while nicks are accompanied by essentially no collateral local mutagenesis, and thus provide a safer approach to gene correction. Defining efficacy as the ratio of gene correction to local deletion, nicks initiate gene correction with 70-fold greater efficacy than do double-strand breaks (29.0±6.0% and 0.42±0.03%, respectively). Thus nicks initiate efficient gene correction, with limited local mutagenesis. These results have clear therapeutic implications, and should inform future design of meganucleases for targeted gene correction." @default.
• W1991129150 created "2016-06-24" @default.
• W1991129150 creator A5063172518 @default.
• W1991129150 creator A5088715864 @default.
• W1991129150 date "2011-09-01" @default.
• W1991129150 modified "2023-10-14" @default.
• W1991129150 title "DNA Nicks Promote Efficient and Safe Targeted Gene Correction" @default.
• W1991129150 cites W1965086193 @default.
• W1991129150 cites W1967999689 @default.
• W1991129150 cites W1982969769 @default.
• W1991129150 cites W2001748204 @default.
• W1991129150 cites W2003646056 @default.
• W1991129150 cites W2005467872 @default.
• W1991129150 cites W2009626008 @default.
• W1991129150 cites W2011067402 @default.
• W1991129150 cites W2030002436 @default.
• W1991129150 cites W2036440495 @default.
• W1991129150 cites W2039316426 @default.
• W1991129150 cites W2043094702 @default.
• W1991129150 cites W2050646440 @default.
• W1991129150 cites W2053679951 @default.
• W1991129150 cites W2058833396 @default.
• W1991129150 cites W2061948650 @default.
• W1991129150 cites W2092633851 @default.
• W1991129150 cites W2092761963 @default.
• W1991129150 cites W2109622089 @default.
• W1991129150 cites W2112006537 @default.
• W1991129150 cites W2113360292 @default.
• W1991129150 cites W2118342841 @default.
• W1991129150 cites W2119693564 @default.
• W1991129150 cites W2120610100 @default.
• W1991129150 cites W2124677401 @default.
• W1991129150 cites W2128377922 @default.
• W1991129150 cites W2135144687 @default.
• W1991129150 cites W2139538055 @default.
• W1991129150 cites W2140494588 @default.
• W1991129150 cites W2143987754 @default.
• W1991129150 cites W2146179684 @default.
• W1991129150 cites W2165918134 @default.
• W1991129150 cites W2323613689 @default.
• W1991129150 cites W4237567990 @default.
• W1991129150 doi "https://doi.org/10.1371/journal.pone.0023981" @default.
• W1991129150 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3164693" @default.
• W1991129150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21912657" @default.
• W1991129150 hasPublicationYear "2011" @default.
• W1991129150 type Work @default.
• W1991129150 sameAs 1991129150 @default.
• W1991129150 citedByCount "58" @default.
• W1991129150 countsByYear W19911291502012 @default.
• W1991129150 countsByYear W19911291502013 @default.
• W1991129150 countsByYear W19911291502014 @default.
• W1991129150 countsByYear W19911291502015 @default.
• W1991129150 countsByYear W19911291502016 @default.
• W1991129150 countsByYear W19911291502017 @default.
• W1991129150 countsByYear W19911291502018 @default.
• W1991129150 countsByYear W19911291502019 @default.
• W1991129150 countsByYear W19911291502020 @default.
• W1991129150 countsByYear W19911291502022 @default.
• W1991129150 crossrefType "journal-article" @default.
• W1991129150 hasAuthorship W1991129150A5063172518 @default.
• W1991129150 hasAuthorship W1991129150A5088715864 @default.
• W1991129150 hasBestOaLocation W19911291501 @default.
• W1991129150 hasConcept C102744134 @default.
• W1991129150 hasConcept C104317684 @default.
• W1991129150 hasConcept C111829913 @default.
• W1991129150 hasConcept C134935766 @default.
• W1991129150 hasConcept C143425029 @default.
• W1991129150 hasConcept C16318435 @default.
• W1991129150 hasConcept C178169997 @default.
• W1991129150 hasConcept C501734568 @default.
• W1991129150 hasConcept C54355233 @default.
• W1991129150 hasConcept C552990157 @default.
• W1991129150 hasConcept C70721500 @default.
• W1991129150 hasConcept C86803240 @default.
• W1991129150 hasConceptScore W1991129150C102744134 @default.
• W1991129150 hasConceptScore W1991129150C104317684 @default.
• W1991129150 hasConceptScore W1991129150C111829913 @default.
• W1991129150 hasConceptScore W1991129150C134935766 @default.
• W1991129150 hasConceptScore W1991129150C143425029 @default.
• W1991129150 hasConceptScore W1991129150C16318435 @default.
• W1991129150 hasConceptScore W1991129150C178169997 @default.
• W1991129150 hasConceptScore W1991129150C501734568 @default.
• W1991129150 hasConceptScore W1991129150C54355233 @default.
• W1991129150 hasConceptScore W1991129150C552990157 @default.
• W1991129150 hasConceptScore W1991129150C70721500 @default.
• W1991129150 hasConceptScore W1991129150C86803240 @default.
• W1991129150 hasIssue "9" @default.
• W1991129150 hasLocation W19911291501 @default.
• W1991129150 hasLocation W19911291502 @default.
• W1991129150 hasLocation W19911291503 @default.
• W1991129150 hasLocation W19911291504 @default.
• W1991129150 hasOpenAccess W1991129150 @default.
• W1991129150 hasPrimaryLocation W19911291501 @default.
• W1991129150 hasRelatedWork W2016949934 @default.
• W1991129150 hasRelatedWork W2026518361 @default.
• W1991129150 hasRelatedWork W2161217413 @default.
• W1991129150 hasRelatedWork W2612428976 @default.
• W1991129150 hasRelatedWork W2735460642 @default.

• next