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- W1991130117 endingPage "215" @default.
- W1991130117 startingPage "201" @default.
- W1991130117 abstract "Radiotherapy is one of the principal modalities of cancer treatment, but the delivery of a curative dose of ionizing radiation (IR) to the tumour is frequently limited by the need to protect the normal tissues within the irradiated area from radiation damage. This problem could be circumvented if tumour cells could be selectively sensitized to killing by IR. One way to achieve this goal would be to transduce the tumour cells with expression vectors carrying toxin genes under the control of promoters that are inactive unless induced by IR. For this approach to be successful, two parameters must be met: (i) the expression vector has to be delivered to the tumour or its immediate vicinity (e.g. its vasculature) and (ii) the promoter driving the expression of the toxin gene has to have negligible basal activity, yet has to be activated by clinically-achievable doses of IR. Several vectors that fulfil these criteria are currently reaching clinical trials. In this review, we examine the response of mammalian cells to IR, and the current status of radiation-induced suicide gene therapy that is dependent on this response." @default.
- W1991130117 created "2016-06-24" @default.
- W1991130117 creator A5015115550 @default.
- W1991130117 creator A5071043734 @default.
- W1991130117 creator A5076452975 @default.
- W1991130117 date "2004-03-04" @default.
- W1991130117 modified "2023-09-23" @default.
- W1991130117 title "Activation of stress-responsive promoters by ionizing radiation for deployment in targeted gene therapy" @default.
- W1991130117 cites W100225602 @default.
- W1991130117 cites W140530753 @default.
- W1991130117 cites W1572772426 @default.
- W1991130117 cites W1606113473 @default.
- W1991130117 cites W1650797637 @default.
- W1991130117 cites W1657827244 @default.
- W1991130117 cites W1827829058 @default.
- W1991130117 cites W1847864430 @default.
- W1991130117 cites W1867555874 @default.
- W1991130117 cites W1925670358 @default.
- W1991130117 cites W1964742508 @default.
- W1991130117 cites W1968930897 @default.
- W1991130117 cites W1969795460 @default.
- W1991130117 cites W1972163180 @default.
- W1991130117 cites W1973584204 @default.
- W1991130117 cites W1978406914 @default.
- W1991130117 cites W1986026405 @default.
- W1991130117 cites W1986179131 @default.
- W1991130117 cites W1986342354 @default.
- W1991130117 cites W1987110949 @default.
- W1991130117 cites W1987453246 @default.
- W1991130117 cites W1987520716 @default.
- W1991130117 cites W1989223012 @default.
- W1991130117 cites W1991494214 @default.
- W1991130117 cites W1992506198 @default.
- W1991130117 cites W1993151115 @default.
- W1991130117 cites W1995741673 @default.
- W1991130117 cites W1999660891 @default.
- W1991130117 cites W2004480518 @default.
- W1991130117 cites W2006234418 @default.
- W1991130117 cites W2008715871 @default.
- W1991130117 cites W2009745999 @default.
- W1991130117 cites W2011229774 @default.
- W1991130117 cites W2011894210 @default.
- W1991130117 cites W2013675727 @default.
- W1991130117 cites W2015314126 @default.
- W1991130117 cites W2015481819 @default.
- W1991130117 cites W2015519364 @default.
- W1991130117 cites W2016119805 @default.
- W1991130117 cites W2016127568 @default.
- W1991130117 cites W2018884388 @default.
- W1991130117 cites W2021253208 @default.
- W1991130117 cites W2022811243 @default.
- W1991130117 cites W2024996523 @default.
- W1991130117 cites W2029057997 @default.
- W1991130117 cites W2030283142 @default.
- W1991130117 cites W2032027012 @default.
- W1991130117 cites W2032603938 @default.
- W1991130117 cites W2034269086 @default.
- W1991130117 cites W2037148821 @default.
- W1991130117 cites W2041186477 @default.
- W1991130117 cites W2045077089 @default.
- W1991130117 cites W2047447041 @default.
- W1991130117 cites W2047491571 @default.
- W1991130117 cites W2050548612 @default.
- W1991130117 cites W2050912993 @default.
- W1991130117 cites W2051241476 @default.
- W1991130117 cites W2052537645 @default.
- W1991130117 cites W2052885484 @default.
- W1991130117 cites W2053301688 @default.
- W1991130117 cites W2059185804 @default.
- W1991130117 cites W2061236267 @default.
- W1991130117 cites W2062809291 @default.
- W1991130117 cites W2063092179 @default.
- W1991130117 cites W2064597261 @default.
- W1991130117 cites W2066613757 @default.
- W1991130117 cites W2068932627 @default.
- W1991130117 cites W2069455791 @default.
- W1991130117 cites W2074061637 @default.
- W1991130117 cites W2074222004 @default.
- W1991130117 cites W2074312794 @default.
- W1991130117 cites W2074511763 @default.
- W1991130117 cites W2080125477 @default.
- W1991130117 cites W2080772875 @default.
- W1991130117 cites W2081774189 @default.
- W1991130117 cites W2082392586 @default.
- W1991130117 cites W2084733813 @default.
- W1991130117 cites W2085482078 @default.
- W1991130117 cites W2086981199 @default.
- W1991130117 cites W2090280626 @default.
- W1991130117 cites W2092537625 @default.
- W1991130117 cites W2098132781 @default.
- W1991130117 cites W2101639664 @default.
- W1991130117 cites W2108603302 @default.
- W1991130117 cites W2110380385 @default.
- W1991130117 cites W2118364944 @default.
- W1991130117 cites W2124501557 @default.
- W1991130117 cites W2125607221 @default.
- W1991130117 cites W2132000251 @default.
- W1991130117 cites W2147678437 @default.