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- W1991133290 endingPage "479" @default.
- W1991133290 startingPage "463" @default.
- W1991133290 abstract "Human malignant pleural mesothelioma (hMPM) is an aggressive asbestos-associated cancer, the incidence of which is increasing and which, despite progress in diagnosis and therapy, continues to have a poor prognosis. Asbestos fibers induce aberrant cell signaling, leading to proto-oncogene activation and chemoresistance. In this review, we discuss the evolution of pharmacological management of hMPM up to the most recent advances. Monotherapy with single cytotoxic drugs achieves modest objective response rates, seldom reaching 30%. However, combination regimens using novel drugs and standard molecules are showing gradually improving responses and clinical benefits. Phase II/III studies have identified pemetrexed, a multitarget folate pathway inhibitor in combination with platinum derivatives, and the cisplatin/gemcitabine association as front-line chemotherapy for hMPM. Detailed knowledge of molecular mechanisms of signal transduction and neoangiogenesis in hMPM should aid in the design and screening of other promising compounds such as more efficacious receptor tyrosine kinase inhibitors." @default.
- W1991133290 created "2016-06-24" @default.
- W1991133290 creator A5007286753 @default.
- W1991133290 creator A5035985266 @default.
- W1991133290 date "2011-08-01" @default.
- W1991133290 modified "2023-09-25" @default.
- W1991133290 title "Combined chemotherapy with cytotoxic and targeted compounds for the management of human malignant pleural mesothelioma" @default.
- W1991133290 cites W110928371 @default.
- W1991133290 cites W1517335907 @default.
- W1991133290 cites W1869777220 @default.
- W1991133290 cites W1966381243 @default.
- W1991133290 cites W1967505269 @default.
- W1991133290 cites W1968027087 @default.
- W1991133290 cites W1968154700 @default.
- W1991133290 cites W1971056168 @default.
- W1991133290 cites W1971170437 @default.
- W1991133290 cites W1971760530 @default.
- W1991133290 cites W1975069903 @default.
- W1991133290 cites W1976015582 @default.
- W1991133290 cites W1977449506 @default.
- W1991133290 cites W1978327177 @default.
- W1991133290 cites W1981629771 @default.
- W1991133290 cites W1982655333 @default.
- W1991133290 cites W1985690846 @default.
- W1991133290 cites W1985990605 @default.
- W1991133290 cites W1987724930 @default.
- W1991133290 cites W1988563723 @default.
- W1991133290 cites W1990104009 @default.
- W1991133290 cites W1992389777 @default.
- W1991133290 cites W1992718174 @default.
- W1991133290 cites W1993968227 @default.
- W1991133290 cites W1999102644 @default.
- W1991133290 cites W2000001069 @default.
- W1991133290 cites W2002574573 @default.
- W1991133290 cites W2005499917 @default.
- W1991133290 cites W2008766290 @default.
- W1991133290 cites W2010146492 @default.
- W1991133290 cites W2010808455 @default.
- W1991133290 cites W2012492706 @default.
- W1991133290 cites W2013288710 @default.
- W1991133290 cites W2013640959 @default.
- W1991133290 cites W2014943535 @default.
- W1991133290 cites W2014956732 @default.
- W1991133290 cites W2026379260 @default.
- W1991133290 cites W2028701020 @default.
- W1991133290 cites W2037614469 @default.
- W1991133290 cites W2040333874 @default.
- W1991133290 cites W2042724367 @default.
- W1991133290 cites W2045400845 @default.
- W1991133290 cites W2048277025 @default.
- W1991133290 cites W2050014528 @default.
- W1991133290 cites W2050291724 @default.
- W1991133290 cites W2050862531 @default.
- W1991133290 cites W2051829053 @default.
- W1991133290 cites W2054256117 @default.
- W1991133290 cites W2055695980 @default.
- W1991133290 cites W2059890247 @default.
- W1991133290 cites W2060047122 @default.
- W1991133290 cites W2062011274 @default.
- W1991133290 cites W2062482778 @default.
- W1991133290 cites W2064074167 @default.
- W1991133290 cites W2064212361 @default.
- W1991133290 cites W2065144267 @default.
- W1991133290 cites W2067583075 @default.
- W1991133290 cites W2067837009 @default.
- W1991133290 cites W2068244585 @default.
- W1991133290 cites W2071347191 @default.
- W1991133290 cites W2073302269 @default.
- W1991133290 cites W2073646991 @default.
- W1991133290 cites W2074669585 @default.
- W1991133290 cites W2075407720 @default.
- W1991133290 cites W2076244147 @default.
- W1991133290 cites W2087304448 @default.
- W1991133290 cites W2087526884 @default.
- W1991133290 cites W2087667095 @default.
- W1991133290 cites W2089481267 @default.
- W1991133290 cites W2090282518 @default.
- W1991133290 cites W2090551745 @default.
- W1991133290 cites W2090699402 @default.
- W1991133290 cites W2090821179 @default.
- W1991133290 cites W2093185281 @default.
- W1991133290 cites W2094586578 @default.
- W1991133290 cites W2096085739 @default.
- W1991133290 cites W2097157431 @default.
- W1991133290 cites W2102627969 @default.
- W1991133290 cites W2113417569 @default.
- W1991133290 cites W2113447234 @default.
- W1991133290 cites W2113954569 @default.
- W1991133290 cites W2115750982 @default.
- W1991133290 cites W2117623649 @default.
- W1991133290 cites W2122514344 @default.
- W1991133290 cites W2125300238 @default.
- W1991133290 cites W2125780801 @default.
- W1991133290 cites W2127235139 @default.
- W1991133290 cites W2129967236 @default.
- W1991133290 cites W2131894349 @default.
- W1991133290 cites W2131934427 @default.
- W1991133290 cites W2134594118 @default.