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• W1991136224 abstract "1 We compared the effects of NG-monomethyl-l-arginine (l-NMMA), an NO synthase inhibitor, on vasodilatation produced by acetylcholine and methacholine in human forearm vasculature. 2 Acetylcholine (83 nmol min−1) infused into the brachial artery of 8 healthy volunteers caused a submaximal increase in forearm blood flow, measured by venous occlusion plethysmography, from 3.3 ± 0.5 (mean ± s.e.mean) to 13.3 ± 1.7 ml min−1 100 ml−1. 3 Co-infusion of l-NMMA (4 μmol min−1) with acetylcholine (83 nmol min−1) over 6 min resulted in a 58% ± 12% fall in the response to acetylcholine whereas during co-infusion of saline over the same time period in the same subjects (n = 8) on a different day the response to acetylcholine fell by only 9% ± 17% (P < 0.01). 4 Methacholine (1.5 and 15 nmol min−1) increased forearm blood flow from 2.5 ± 0.4 to 5.9 ± 0.9 and from 3.2 ± 0.4 to 17.0 ± 1.9 ml min−1 100 ml−1 respectively. 5 Co-infusion of l-NMMA (4 μmol min−1) had no significant effect on the response to methacholine (1.5 or 15 nmol min−1) when compared with saline control (n = 8). Co-infusion of a higher dose of l-NMMA (8 μmol min−1) with methacholine (1.5 nmol min−1) did not significantly inhibit the vasodilator response (n = 7). 6 These results suggest that, in human forearm vasculature, methacholine acts predominantly through mechanisms other than the l-arginine/nitric oxide pathway." @default.
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• W1991136224 date "1993-10-01" @default.
• W1991136224 modified "2023-09-23" @default.
• W1991136224 title "Differential inhibition by NG-monomethyl-l-arginine of vasodilator effects of acetylcholine and methacholine in human forearm vasculature" @default.
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• W1991136224 doi "https://doi.org/10.1111/j.1476-5381.1993.tb13873.x" @default.
• W1991136224 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2175929" @default.
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