FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991137034> ?p ?o ?g. }

• W1991137034 endingPage "261" @default.
• W1991137034 startingPage "255" @default.
• W1991137034 abstract "The Ser/Thr kinases of the PAR-1/MARK/Kin1 family are conserved regulators of polarity in epithelial and non-epithelial cells [1Pellettieri J. Seydoux G. Anterior-posterior polarity in C. elegans and Drosophila–PARallels and differences.Science. 2002; 298: 1946-1950Crossref PubMed Scopus (105) Google Scholar]. Drosophila PAR-1 localizes laterally in the follicular epithelium of the ovary [2Shulman J.M. Benton R. St Johnston D. The Drosophila homolog of C. elegans PAR-1 organizes the oocyte cytoskeleton and directs oskar mRNA localization to the posterior pole.Cell. 2000; 101: 377-388Abstract Full Text Full Text PDF PubMed Scopus (243) Google Scholar, 3Cox D.N. Lu B. Sun T.Q. Williams L.T. Jan Y.N. Drosophila par-1 is required for oocyte differentiation and microtubule organization.Curr. Biol. 2001; 11: 75-87Abstract Full Text Full Text PDF PubMed Scopus (118) Google Scholar], where it has been shown to function at two distinct levels: It stabilizes the cytoskeleton [3Cox D.N. Lu B. Sun T.Q. Williams L.T. Jan Y.N. Drosophila par-1 is required for oocyte differentiation and microtubule organization.Curr. Biol. 2001; 11: 75-87Abstract Full Text Full Text PDF PubMed Scopus (118) Google Scholar, 4Doerflinger H. Benton R. Shulman J.M. Johnston D.S. The role of PAR-1 in regulating the polarised microtubule cytoskeleton in the Drosophila follicular epithelium.Development. 2003; 130: 3965-3975Crossref PubMed Scopus (126) Google Scholar] and it regulates apical-basal polarity by directly inhibiting lateral assembly of the apical aPKC/Bazooka/PAR-6 complex [5Benton R. Johnston D.S. A conserved oligomerization domain in drosophila Bazooka/PAR-3 is important for apical localization and epithelial polarity.Curr. Biol. 2003; 13: 1330-1334Abstract Full Text Full Text PDF PubMed Scopus (117) Google Scholar, 6Benton R. Johnston D.S. Drosophila PAR-1 and 14–3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells.Cell. 2003; 115: 691-704Abstract Full Text Full Text PDF PubMed Scopus (306) Google Scholar]. However, it has been unclear how lateral localization of Drosophila PAR-1 is achieved and whether this localization contributes to epithelial polarity in vivo. Here we show that, through its spacer domain, Drosophila PAR-1 accumulates on the lateral plasma membrane (PM) in cells of the follicular epithelium (FE). Rescue experiments indicate that in FE cells PAR-1 kinase activity is essential for all the described functions of PAR-1. In contrast, the spacer domain of PAR-1 is required for apical-basal polarity and growth control but is dispensable for microtubule (MT) stabilization. Our data indicate that the spacer domain of PAR-1 is required for lateral PM localization of PAR-1 kinase and for development of a polarized FE." @default.
• W1991137034 created "2016-06-24" @default.
• W1991137034 creator A5006681896 @default.
• W1991137034 creator A5018833621 @default.
• W1991137034 creator A5086461219 @default.
• W1991137034 date "2005-02-01" @default.
• W1991137034 modified "2023-09-23" @default.
• W1991137034 title "The Drosophila PAR-1 Spacer Domain Is Required for Lateral Membrane Association and for Polarization of Follicular Epithelial Cells" @default.
• W1991137034 cites W1566790599 @default.
• W1991137034 cites W1965247392 @default.
• W1991137034 cites W1976226144 @default.
• W1991137034 cites W1976577398 @default.
• W1991137034 cites W1986368793 @default.
• W1991137034 cites W2001443225 @default.
• W1991137034 cites W2004071190 @default.
• W1991137034 cites W2006229889 @default.
• W1991137034 cites W2008462998 @default.
• W1991137034 cites W2010335195 @default.
• W1991137034 cites W2013791364 @default.
• W1991137034 cites W2015114060 @default.
• W1991137034 cites W2026070789 @default.
• W1991137034 cites W2035424802 @default.
• W1991137034 cites W2036312848 @default.
• W1991137034 cites W2046831598 @default.
• W1991137034 cites W2060686949 @default.
• W1991137034 cites W2062721107 @default.
• W1991137034 cites W2063368579 @default.
• W1991137034 cites W2071731154 @default.
• W1991137034 cites W2080344484 @default.
• W1991137034 cites W2082861222 @default.
• W1991137034 cites W2096658690 @default.
• W1991137034 cites W2105513224 @default.
• W1991137034 cites W2112310659 @default.
• W1991137034 cites W2118759548 @default.
• W1991137034 cites W2120525124 @default.
• W1991137034 cites W2130965044 @default.
• W1991137034 cites W2133181593 @default.
• W1991137034 cites W2169987970 @default.
• W1991137034 cites W2189435626 @default.
• W1991137034 doi "https://doi.org/10.1016/j.cub.2005.01.033" @default.
• W1991137034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15694310" @default.
• W1991137034 hasPublicationYear "2005" @default.
• W1991137034 type Work @default.
• W1991137034 sameAs 1991137034 @default.
• W1991137034 citedByCount "28" @default.
• W1991137034 countsByYear W19911370342012 @default.
• W1991137034 countsByYear W19911370342013 @default.
• W1991137034 countsByYear W19911370342014 @default.
• W1991137034 countsByYear W19911370342017 @default.
• W1991137034 countsByYear W19911370342018 @default.
• W1991137034 countsByYear W19911370342019 @default.
• W1991137034 countsByYear W19911370342020 @default.
• W1991137034 crossrefType "journal-article" @default.
• W1991137034 hasAuthorship W1991137034A5006681896 @default.
• W1991137034 hasAuthorship W1991137034A5018833621 @default.
• W1991137034 hasAuthorship W1991137034A5086461219 @default.
• W1991137034 hasBestOaLocation W19911370341 @default.
• W1991137034 hasConcept C104317684 @default.
• W1991137034 hasConcept C142669718 @default.
• W1991137034 hasConcept C1491633281 @default.
• W1991137034 hasConcept C196843134 @default.
• W1991137034 hasConcept C20418707 @default.
• W1991137034 hasConcept C2776041557 @default.
• W1991137034 hasConcept C2776690073 @default.
• W1991137034 hasConcept C49353375 @default.
• W1991137034 hasConcept C54355233 @default.
• W1991137034 hasConcept C86803240 @default.
• W1991137034 hasConcept C95444343 @default.
• W1991137034 hasConceptScore W1991137034C104317684 @default.
• W1991137034 hasConceptScore W1991137034C142669718 @default.
• W1991137034 hasConceptScore W1991137034C1491633281 @default.
• W1991137034 hasConceptScore W1991137034C196843134 @default.
• W1991137034 hasConceptScore W1991137034C20418707 @default.
• W1991137034 hasConceptScore W1991137034C2776041557 @default.
• W1991137034 hasConceptScore W1991137034C2776690073 @default.
• W1991137034 hasConceptScore W1991137034C49353375 @default.
• W1991137034 hasConceptScore W1991137034C54355233 @default.
• W1991137034 hasConceptScore W1991137034C86803240 @default.
• W1991137034 hasConceptScore W1991137034C95444343 @default.
• W1991137034 hasIssue "3" @default.
• W1991137034 hasLocation W19911370341 @default.
• W1991137034 hasLocation W19911370342 @default.
• W1991137034 hasOpenAccess W1991137034 @default.
• W1991137034 hasPrimaryLocation W19911370341 @default.
• W1991137034 hasRelatedWork W1964192572 @default.
• W1991137034 hasRelatedWork W1995649075 @default.
• W1991137034 hasRelatedWork W1999411716 @default.
• W1991137034 hasRelatedWork W2049948717 @default.
• W1991137034 hasRelatedWork W2076480564 @default.
• W1991137034 hasRelatedWork W2144495019 @default.
• W1991137034 hasRelatedWork W2151352552 @default.
• W1991137034 hasRelatedWork W2498417509 @default.
• W1991137034 hasRelatedWork W4220942634 @default.
• W1991137034 hasRelatedWork W1927607265 @default.
• W1991137034 hasVolume "15" @default.
• W1991137034 isParatext "false" @default.
• W1991137034 isRetracted "false" @default.
• W1991137034 magId "1991137034" @default.

• next