FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991137257> ?p ?o ?g. }

• W1991137257 endingPage "S105" @default.
• W1991137257 startingPage "S101" @default.
• W1991137257 abstract "BackgroundThe first aim of our long-term study was to describe the natural history of diabetic nephropathy in 59 normotensive type 1 diabetic patients. Secondly, we evaluated genetic and nongenetic progression promoters.MethodsThe following progression promoters were determined: the insertion/deletion polymorphism in the angiotensin converting enzyme (ACE) gene, blood pressure, albuminuria, hemoglobin A1c, cholesterol, smoking, height, and gender. We studied the natural history by measuring 51Cr-EDTA plasma clearance at yearly intervals at least three times during [median (range)] 5.5 (2.2 to 18.3) years.ResultsAt baseline the three groups (II, N = 11; ID, N = 25, and DD, N = 23) had comparable GFR (103 ± 16; 99 ± 19; 113 ± 22 ml/min/1.73 m2, respectively; mean ± SD), arterial blood pressure, albuminuria, and hemoglobin A1c. During the follow-up there was a median rate of decline in GFR in all 59 patients of 1.2 (range 12.9 to –4.4) ml/min/year. During the study period no significant differences were observed in: the rate of decline in glomerular filtration rate [median (range) 0.9 (10.6 to –1.9); 2.5 (12.9 to –4.4); 1.4 (10.8 to –1.9 ml/min/year)], arterial blood pressure, albuminuria, hemoglobin A1c or cholesterol between the three groups (II, ID and DD), respectively. At baseline, multiple linear regression analysis including the above-mentioned putative risk factors revealed that albuminuria, short stature, and male gender independently predict an enhanced decline in GFR [R2 (adjusted) = 0.33; P < 0.002]. During the follow-up period, only albuminuria acted as an independent progression promoter [R2 (adjusted) = 0.37; P < 0.0001].ConclusionsOur study revealed a rather slow progression of kidney disease in normotensive type 1 diabetic patients with diabetic nephropathy. Albuminuria, short stature, and male gender act as progression promoters in such patients. The first aim of our long-term study was to describe the natural history of diabetic nephropathy in 59 normotensive type 1 diabetic patients. Secondly, we evaluated genetic and nongenetic progression promoters. The following progression promoters were determined: the insertion/deletion polymorphism in the angiotensin converting enzyme (ACE) gene, blood pressure, albuminuria, hemoglobin A1c, cholesterol, smoking, height, and gender. We studied the natural history by measuring 51Cr-EDTA plasma clearance at yearly intervals at least three times during [median (range)] 5.5 (2.2 to 18.3) years. At baseline the three groups (II, N = 11; ID, N = 25, and DD, N = 23) had comparable GFR (103 ± 16; 99 ± 19; 113 ± 22 ml/min/1.73 m2, respectively; mean ± SD), arterial blood pressure, albuminuria, and hemoglobin A1c. During the follow-up there was a median rate of decline in GFR in all 59 patients of 1.2 (range 12.9 to –4.4) ml/min/year. During the study period no significant differences were observed in: the rate of decline in glomerular filtration rate [median (range) 0.9 (10.6 to –1.9); 2.5 (12.9 to –4.4); 1.4 (10.8 to –1.9 ml/min/year)], arterial blood pressure, albuminuria, hemoglobin A1c or cholesterol between the three groups (II, ID and DD), respectively. At baseline, multiple linear regression analysis including the above-mentioned putative risk factors revealed that albuminuria, short stature, and male gender independently predict an enhanced decline in GFR [R2 (adjusted) = 0.33; P < 0.002]. During the follow-up period, only albuminuria acted as an independent progression promoter [R2 (adjusted) = 0.37; P < 0.0001]. Our study revealed a rather slow progression of kidney disease in normotensive type 1 diabetic patients with diabetic nephropathy. Albuminuria, short stature, and male gender act as progression promoters in such patients." @default.
• W1991137257 created "2016-06-24" @default.
• W1991137257 creator A5024547064 @default.
• W1991137257 creator A5041442093 @default.
• W1991137257 creator A5041643161 @default.
• W1991137257 creator A5044496367 @default.
• W1991137257 creator A5070884818 @default.
• W1991137257 creator A5077987218 @default.
• W1991137257 creator A5083703658 @default.
• W1991137257 creator A5084645948 @default.
• W1991137257 date "1999-07-01" @default.
• W1991137257 modified "2023-10-16" @default.
• W1991137257 title "Progression of diabetic nephropathy in normotensive type 1 diabetic patients" @default.
• W1991137257 cites W150250187 @default.
• W1991137257 cites W1972939258 @default.
• W1991137257 cites W1980900540 @default.
• W1991137257 cites W1995112840 @default.
• W1991137257 cites W1995721214 @default.
• W1991137257 cites W2001049748 @default.
• W1991137257 cites W2005718118 @default.
• W1991137257 cites W2006779113 @default.
• W1991137257 cites W2007098380 @default.
• W1991137257 cites W2012888011 @default.
• W1991137257 cites W2013709047 @default.
• W1991137257 cites W2028465222 @default.
• W1991137257 cites W2033905400 @default.
• W1991137257 cites W2042708695 @default.
• W1991137257 cites W2044276013 @default.
• W1991137257 cites W2059368542 @default.
• W1991137257 cites W2059571085 @default.
• W1991137257 cites W2065955863 @default.
• W1991137257 cites W2073935745 @default.
• W1991137257 cites W2077386636 @default.
• W1991137257 cites W2091698284 @default.
• W1991137257 cites W2122100165 @default.
• W1991137257 cites W2126157581 @default.
• W1991137257 cites W2143039477 @default.
• W1991137257 cites W2258639162 @default.
• W1991137257 cites W2615684303 @default.
• W1991137257 doi "https://doi.org/10.1046/j.1523-1755.1999.07125.x" @default.
• W1991137257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10412749" @default.
• W1991137257 hasPublicationYear "1999" @default.
• W1991137257 type Work @default.
• W1991137257 sameAs 1991137257 @default.
• W1991137257 citedByCount "88" @default.
• W1991137257 countsByYear W19911372572012 @default.
• W1991137257 countsByYear W19911372572013 @default.
• W1991137257 countsByYear W19911372572015 @default.
• W1991137257 countsByYear W19911372572016 @default.
• W1991137257 countsByYear W19911372572017 @default.
• W1991137257 countsByYear W19911372572018 @default.
• W1991137257 countsByYear W19911372572019 @default.
• W1991137257 countsByYear W19911372572020 @default.
• W1991137257 countsByYear W19911372572021 @default.
• W1991137257 countsByYear W19911372572022 @default.
• W1991137257 countsByYear W19911372572023 @default.
• W1991137257 crossrefType "journal-article" @default.
• W1991137257 hasAuthorship W1991137257A5024547064 @default.
• W1991137257 hasAuthorship W1991137257A5041442093 @default.
• W1991137257 hasAuthorship W1991137257A5041643161 @default.
• W1991137257 hasAuthorship W1991137257A5044496367 @default.
• W1991137257 hasAuthorship W1991137257A5070884818 @default.
• W1991137257 hasAuthorship W1991137257A5077987218 @default.
• W1991137257 hasAuthorship W1991137257A5083703658 @default.
• W1991137257 hasAuthorship W1991137257A5084645948 @default.
• W1991137257 hasBestOaLocation W19911372571 @default.
• W1991137257 hasConcept C126322002 @default.
• W1991137257 hasConcept C126894567 @default.
• W1991137257 hasConcept C134018914 @default.
• W1991137257 hasConcept C159641895 @default.
• W1991137257 hasConcept C2776174234 @default.
• W1991137257 hasConcept C2777180221 @default.
• W1991137257 hasConcept C2778917026 @default.
• W1991137257 hasConcept C2779922275 @default.
• W1991137257 hasConcept C2781184683 @default.
• W1991137257 hasConcept C555293320 @default.
• W1991137257 hasConcept C71924100 @default.
• W1991137257 hasConcept C84393581 @default.
• W1991137257 hasConceptScore W1991137257C126322002 @default.
• W1991137257 hasConceptScore W1991137257C126894567 @default.
• W1991137257 hasConceptScore W1991137257C134018914 @default.
• W1991137257 hasConceptScore W1991137257C159641895 @default.
• W1991137257 hasConceptScore W1991137257C2776174234 @default.
• W1991137257 hasConceptScore W1991137257C2777180221 @default.
• W1991137257 hasConceptScore W1991137257C2778917026 @default.
• W1991137257 hasConceptScore W1991137257C2779922275 @default.
• W1991137257 hasConceptScore W1991137257C2781184683 @default.
• W1991137257 hasConceptScore W1991137257C555293320 @default.
• W1991137257 hasConceptScore W1991137257C71924100 @default.
• W1991137257 hasConceptScore W1991137257C84393581 @default.
• W1991137257 hasLocation W19911372571 @default.
• W1991137257 hasLocation W19911372572 @default.
• W1991137257 hasOpenAccess W1991137257 @default.
• W1991137257 hasPrimaryLocation W19911372571 @default.
• W1991137257 hasRelatedWork W1816896826 @default.
• W1991137257 hasRelatedWork W2009602329 @default.
• W1991137257 hasRelatedWork W2013701055 @default.
• W1991137257 hasRelatedWork W2061298156 @default.

• next