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- W1991140601 abstract "Abstract High-performance liquid Chromatographic (HPLC) procedures were developed for determination of pilocarpine and its major metabolite, pilocarpic acid, in ocular tissues. Chromatographic separation was carried out on an octadecyl reverse-phase column. The mobile phase consisted of 97% (v/v) water, 3% (v/v) methanol. and 5% (w/v) potassium dihydrogen phosphate. At a flow rate of 1.0 ml/min and by monitoring UV absorbance at 215 nm, the retention times for pilocarpine and pilocarpic acid are approximately 18 and 10 min, respectively. In addition, a method to extract pilocarpine and pilocarpic acid from ocular tissues prior to chromatography has been developed and applied to routine tissue drug analysis. This assay method is able to detect 20 ng of compound and is shown to be linear in the range 1–50 μg/ml. With this level of sensitivity, tissues from three eyes need to be pooled, extracted, and assayed in order to monitor pilocarpine and pilocarpic acid ocular disposition." @default.
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- W1991140601 date "1984-07-01" @default.
- W1991140601 modified "2023-09-25" @default.
- W1991140601 title "High-performance Chromatographic determination of pilocarpine and pilocarpic acid in ocular tissues" @default.
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- W1991140601 doi "https://doi.org/10.1016/0378-5173(84)90175-3" @default.
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