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• W1991140984 abstract "Two decades ago best supportive care was considered a valid therapeutic option for advanced non-small cell lung cancer (NSCLC) patients until the evidence derived from meta-analysis showed symptom improvement and a survival advantage from systemic chemotherapy. A further advantage was reported when docetaxel and pemetrexed were used as second-line treatment after failure of first-line platinum-based chemotherapy. Furthermore, the biologic therapies targeting the epidermal growth factor receptor – erlotinib and gefitinib – have modified the therapeutic approach to second- and third-line treatment of NSCLC patients. In fact, to date, erlotinib is the only drug to be licensed for third-line therapy worldwide. So, third-line represents a new frontier to be assessed in advanced NSCLC patients. Third-line therapy is very hard to define correctly as it is difficult to interpret the currently available evidence-based data. A better knowledge of cellular biology will certainly encourage clinical research and could allow oncologists to best select patients and treatments. Here we review the state of the art of third-line therapy in the treatment of NSCLC patients." @default.
• W1991140984 created "2016-06-24" @default.
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• W1991140984 date "2009-01-01" @default.
• W1991140984 modified "2023-10-16" @default.
• W1991140984 title "Third-Line Therapy for Advanced Non-Small-Cell Lung Cancer Patients: A Feasible Therapeutic Option?" @default.
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• W1991140984 doi "https://doi.org/10.1159/000258503" @default.
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• W1991140984 hasPublicationYear "2009" @default.
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