FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991151861> ?p ?o ?g. }

• W1991151861 endingPage "e1005152" @default.
• W1991151861 startingPage "e1005152" @default.
• W1991151861 abstract "Candida albicans is a major invasive fungal pathogen in humans. An important virulence factor is its ability to switch between the yeast and hyphal forms, and these filamentous forms are important in tissue penetration and invasion. A common feature for filamentous growth is the ability to inhibit cell separation after cytokinesis, although it is poorly understood how this process is regulated developmentally. In C. albicans, the formation of filaments during hyphal growth requires changes in septin ring dynamics. In this work, we studied the functional relationship between septins and the transcription factor Ace2, which controls the expression of enzymes that catalyze septum degradation. We found that alternative translation initiation produces two Ace2 isoforms. While full-length Ace2, Ace2L, influences septin dynamics in a transcription-independent manner in hyphal cells but not in yeast cells, the use of methionine-55 as the initiation codon gives rise to Ace2S, which functions as the nuclear transcription factor required for the expression of cell separation genes. Genetic evidence indicates that Ace2L influences the incorporation of the Sep7 septin to hyphal septin rings in order to avoid inappropriate activation of cell separation during filamentous growth. Interestingly, a natural single nucleotide polymorphism (SNP) present in the C. albicans WO-1 background and other C. albicans commensal and clinical isolates generates a stop codon in the ninth codon of Ace2L that mimics the phenotype of cells lacking Ace2L. Finally, we report that Ace2L and Ace2S interact with the NDR kinase Cbk1 and that impairing activity of this kinase results in a defect in septin dynamics similar to that of hyphal cells lacking Ace2L. Together, our findings identify Ace2L and the NDR kinase Cbk1 as new elements of the signaling system that modify septin ring dynamics in hyphae to allow cell-chain formation, a feature that appears to have evolved in specific C. albicans lineages." @default.
• W1991151861 created "2016-06-24" @default.
• W1991151861 creator A5019231415 @default.
• W1991151861 creator A5019704848 @default.
• W1991151861 creator A5028683755 @default.
• W1991151861 creator A5032627099 @default.
• W1991151861 creator A5038884362 @default.
• W1991151861 creator A5039789883 @default.
• W1991151861 creator A5048762675 @default.
• W1991151861 creator A5058333700 @default.
• W1991151861 creator A5058547529 @default.
• W1991151861 creator A5070515468 @default.
• W1991151861 creator A5075596656 @default.
• W1991151861 creator A5076359899 @default.
• W1991151861 creator A5080751289 @default.
• W1991151861 date "2015-04-15" @default.
• W1991151861 modified "2023-10-17" @default.
• W1991151861 title "A Single Nucleotide Polymorphism Uncovers a Novel Function for the Transcription Factor Ace2 during Candida albicans Hyphal Development" @default.
• W1991151861 cites W1565122441 @default.
• W1991151861 cites W1937476509 @default.
• W1991151861 cites W1964685333 @default.
• W1991151861 cites W1978966221 @default.
• W1991151861 cites W1987342892 @default.
• W1991151861 cites W1994902822 @default.
• W1991151861 cites W1997437177 @default.
• W1991151861 cites W2000600916 @default.
• W1991151861 cites W2001229384 @default.
• W1991151861 cites W2001652771 @default.
• W1991151861 cites W2008054941 @default.
• W1991151861 cites W2008513207 @default.
• W1991151861 cites W2012991384 @default.
• W1991151861 cites W2015593638 @default.
• W1991151861 cites W2017324564 @default.
• W1991151861 cites W2022670574 @default.
• W1991151861 cites W2026969336 @default.
• W1991151861 cites W2035091329 @default.
• W1991151861 cites W2037580878 @default.
• W1991151861 cites W2040362471 @default.
• W1991151861 cites W2041308920 @default.
• W1991151861 cites W2049505636 @default.
• W1991151861 cites W2057764157 @default.
• W1991151861 cites W2058813601 @default.
• W1991151861 cites W2060501484 @default.
• W1991151861 cites W2063424209 @default.
• W1991151861 cites W2065458745 @default.
• W1991151861 cites W2066599845 @default.
• W1991151861 cites W2069765131 @default.
• W1991151861 cites W2073639964 @default.
• W1991151861 cites W2074766907 @default.
• W1991151861 cites W2075471766 @default.
• W1991151861 cites W2078116784 @default.
• W1991151861 cites W2082143788 @default.
• W1991151861 cites W2083378865 @default.
• W1991151861 cites W2086589284 @default.
• W1991151861 cites W2091121523 @default.
• W1991151861 cites W2092853099 @default.
• W1991151861 cites W2097284852 @default.
• W1991151861 cites W2103453943 @default.
• W1991151861 cites W2119093018 @default.
• W1991151861 cites W2120741544 @default.
• W1991151861 cites W2126087968 @default.
• W1991151861 cites W2127422455 @default.
• W1991151861 cites W2130652636 @default.
• W1991151861 cites W2132518731 @default.
• W1991151861 cites W2141046490 @default.
• W1991151861 cites W2141573544 @default.
• W1991151861 cites W2141797392 @default.
• W1991151861 cites W2143178270 @default.
• W1991151861 cites W2144365463 @default.
• W1991151861 cites W2153252627 @default.
• W1991151861 cites W2155290094 @default.
• W1991151861 cites W2157275967 @default.
• W1991151861 cites W2158047771 @default.
• W1991151861 cites W2158313582 @default.
• W1991151861 cites W2161724899 @default.
• W1991151861 cites W2167603300 @default.
• W1991151861 cites W2168420911 @default.
• W1991151861 cites W2168616898 @default.
• W1991151861 cites W2168705804 @default.
• W1991151861 cites W2169540909 @default.
• W1991151861 cites W2288738973 @default.
• W1991151861 doi "https://doi.org/10.1371/journal.pgen.1005152" @default.
• W1991151861 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4398349" @default.
• W1991151861 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25875512" @default.
• W1991151861 hasPublicationYear "2015" @default.
• W1991151861 type Work @default.
• W1991151861 sameAs 1991151861 @default.
• W1991151861 citedByCount "16" @default.
• W1991151861 countsByYear W19911518612016 @default.
• W1991151861 countsByYear W19911518612017 @default.
• W1991151861 countsByYear W19911518612018 @default.
• W1991151861 countsByYear W19911518612019 @default.
• W1991151861 countsByYear W19911518612020 @default.
• W1991151861 countsByYear W19911518612021 @default.
• W1991151861 crossrefType "journal-article" @default.
• W1991151861 hasAuthorship W1991151861A5019231415 @default.
• W1991151861 hasAuthorship W1991151861A5019704848 @default.
• W1991151861 hasAuthorship W1991151861A5028683755 @default.

• next