FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991158061> ?p ?o ?g. }

• W1991158061 endingPage "1083" @default.
• W1991158061 startingPage "1073" @default.
• W1991158061 abstract "As antioxidants, polyphenols are considered to be potentially useful in preventing chronic diseases in man, including Parkinson's disease (PD), a disease involving dopamine (DA) neurons. Our studies have demonstrated that polyphenols extracted from green tea (GT) can inhibit the uptake of 3H-dopamine (3H-DA) and 1-methyl-4-phenylpyridinium (MPP(+)) by DA transporters (DAT) and partially protect embryonic rat mesencephalic dopaminergic (DAergic) neurons from MPP(+)-induced injury. The inhibitory effects of GT polyphenols on 3H-DA uptake were determined in DAT-pCDNA3-transfected Chinese Hamster Ovary (DAT-CHO) cells and in striatal synaptosomes of C57BL/6 mice in vitro and in vivo. The inhibitory effects on 3H-MPP(+) uptake were determined in primary cultures of embryonic rat mesencephalic DAergic cells. Inhibition of uptake for both 3H-DA and 3H-MPP(+) was dose-dependent in the presence of polyphenols. Incubation with 50 microM MPP(+) resulted in a significant loss of tyrosine-hydroxylase (TH)-positive cells in the primary embryonic mesencephalic cultures, while pretreatment with polyphenols (10 to 30 microg/ml) or mazindol (10 microM), a classical DAT inhibitor, significantly attenuated MPP(+)-induced loss of TH-positive cells. These results suggest that GT polyphenols have inhibitory effects on DAT, through which they block MPP(+) uptake and protect DAergic neurons against MPP(+)-induced injury." @default.
• W1991158061 created "2016-06-24" @default.
• W1991158061 creator A5007172109 @default.
• W1991158061 creator A5033575833 @default.
• W1991158061 creator A5034458392 @default.
• W1991158061 creator A5062951448 @default.
• W1991158061 creator A5068655451 @default.
• W1991158061 date "2003-01-01" @default.
• W1991158061 modified "2023-10-01" @default.
• W1991158061 title "Effects of green tea polyphenols on dopamine uptake and on MPP+-induced dopamine neuron injury" @default.
• W1991158061 cites W1558654722 @default.
• W1991158061 cites W1934800228 @default.
• W1991158061 cites W1973508975 @default.
• W1991158061 cites W1985766933 @default.
• W1991158061 cites W1990115112 @default.
• W1991158061 cites W1994373252 @default.
• W1991158061 cites W1998546832 @default.
• W1991158061 cites W2003266390 @default.
• W1991158061 cites W2012188134 @default.
• W1991158061 cites W2016832784 @default.
• W1991158061 cites W2034747100 @default.
• W1991158061 cites W2035804819 @default.
• W1991158061 cites W2038557175 @default.
• W1991158061 cites W2056560062 @default.
• W1991158061 cites W2079549766 @default.
• W1991158061 cites W2083674889 @default.
• W1991158061 cites W2093463905 @default.
• W1991158061 cites W2097807975 @default.
• W1991158061 cites W2117335809 @default.
• W1991158061 cites W2128187400 @default.
• W1991158061 cites W2129128665 @default.
• W1991158061 cites W2147600591 @default.
• W1991158061 cites W2158240118 @default.
• W1991158061 cites W2168616526 @default.
• W1991158061 cites W2326924383 @default.
• W1991158061 cites W4319425401 @default.
• W1991158061 doi "https://doi.org/10.1016/s0024-3205(02)02347-0" @default.
• W1991158061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12495785" @default.
• W1991158061 hasPublicationYear "2003" @default.
• W1991158061 type Work @default.
• W1991158061 sameAs 1991158061 @default.
• W1991158061 citedByCount "65" @default.
• W1991158061 countsByYear W19911580612012 @default.
• W1991158061 countsByYear W19911580612013 @default.
• W1991158061 countsByYear W19911580612014 @default.
• W1991158061 countsByYear W19911580612015 @default.
• W1991158061 countsByYear W19911580612016 @default.
• W1991158061 countsByYear W19911580612017 @default.
• W1991158061 countsByYear W19911580612018 @default.
• W1991158061 countsByYear W19911580612019 @default.
• W1991158061 countsByYear W19911580612020 @default.
• W1991158061 countsByYear W19911580612021 @default.
• W1991158061 countsByYear W19911580612022 @default.
• W1991158061 countsByYear W19911580612023 @default.
• W1991158061 crossrefType "journal-article" @default.
• W1991158061 hasAuthorship W1991158061A5007172109 @default.
• W1991158061 hasAuthorship W1991158061A5033575833 @default.
• W1991158061 hasAuthorship W1991158061A5034458392 @default.
• W1991158061 hasAuthorship W1991158061A5062951448 @default.
• W1991158061 hasAuthorship W1991158061A5068655451 @default.
• W1991158061 hasConcept C134018914 @default.
• W1991158061 hasConcept C137183658 @default.
• W1991158061 hasConcept C150903083 @default.
• W1991158061 hasConcept C159167319 @default.
• W1991158061 hasConcept C169760540 @default.
• W1991158061 hasConcept C170493617 @default.
• W1991158061 hasConcept C17077164 @default.
• W1991158061 hasConcept C175656101 @default.
• W1991158061 hasConcept C185592680 @default.
• W1991158061 hasConcept C207001950 @default.
• W1991158061 hasConcept C2776755682 @default.
• W1991158061 hasConcept C2778004101 @default.
• W1991158061 hasConcept C2778794669 @default.
• W1991158061 hasConcept C2779126938 @default.
• W1991158061 hasConcept C513476851 @default.
• W1991158061 hasConcept C55493867 @default.
• W1991158061 hasConcept C70899900 @default.
• W1991158061 hasConcept C86803240 @default.
• W1991158061 hasConcept C98274493 @default.
• W1991158061 hasConceptScore W1991158061C134018914 @default.
• W1991158061 hasConceptScore W1991158061C137183658 @default.
• W1991158061 hasConceptScore W1991158061C150903083 @default.
• W1991158061 hasConceptScore W1991158061C159167319 @default.
• W1991158061 hasConceptScore W1991158061C169760540 @default.
• W1991158061 hasConceptScore W1991158061C170493617 @default.
• W1991158061 hasConceptScore W1991158061C17077164 @default.
• W1991158061 hasConceptScore W1991158061C175656101 @default.
• W1991158061 hasConceptScore W1991158061C185592680 @default.
• W1991158061 hasConceptScore W1991158061C207001950 @default.
• W1991158061 hasConceptScore W1991158061C2776755682 @default.
• W1991158061 hasConceptScore W1991158061C2778004101 @default.
• W1991158061 hasConceptScore W1991158061C2778794669 @default.
• W1991158061 hasConceptScore W1991158061C2779126938 @default.
• W1991158061 hasConceptScore W1991158061C513476851 @default.
• W1991158061 hasConceptScore W1991158061C55493867 @default.
• W1991158061 hasConceptScore W1991158061C70899900 @default.
• W1991158061 hasConceptScore W1991158061C86803240 @default.
• W1991158061 hasConceptScore W1991158061C98274493 @default.

• next