Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991175586> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W1991175586 abstract "Abstract The somatostatin analog octreotide has a defined role in the overall management strategy for patients with acromegaly. Octreotide is effective in managing acromegaly both as an adjuvant to surgery and as a primary therapy. Octreotide is also beneficial to radiotherapy-treated patients in that the drug suppresses growth hormone (GH) secretion until the long-term ablative effects of radiation occur. Older patients, those with microadenomas, and those with systemic sequelae of hypersomatatropism benefit from initial primary medical therapy with octreotide. In these patients, the almost invariable biochemical normalization achieved by octreotide therapy renders it an effective alternative to surgery. Complications associated with octreotide are minor in comparison to the benefits, but the requirement for multiple daily injections is currently a major drawback. Approximately 25% of octreotide-treated acromegaly patients develop asymptomatic gallstones or sludge that require no treatment. The impact of sustained attenuation of GH and insulin-like growth factor-I (IGF-I) levels by octreotide on the pathogenesis of the long-term sequelae of hypersomatatropism can now be prospectively evaluated. Novel longer-acting octreotide-delivery mechanisms and new-generation somatostatin analogs will provide further advantages for primary pharmacotherapy in acromegaly." @default.
- W1991175586 created "2016-06-24" @default.
- W1991175586 creator A5066985276 @default.
- W1991175586 date "1995-01-01" @default.
- W1991175586 modified "2023-09-27" @default.
- W1991175586 title "Comprehensive management of acromegaly" @default.
- W1991175586 cites W135455108 @default.
- W1991175586 cites W1974172715 @default.
- W1991175586 cites W1975789485 @default.
- W1991175586 cites W1976617283 @default.
- W1991175586 cites W1988418236 @default.
- W1991175586 cites W1989673315 @default.
- W1991175586 cites W2000280678 @default.
- W1991175586 cites W2005614064 @default.
- W1991175586 cites W2012615488 @default.
- W1991175586 cites W2015421654 @default.
- W1991175586 cites W2030579930 @default.
- W1991175586 cites W2055402549 @default.
- W1991175586 cites W2067794530 @default.
- W1991175586 cites W2072352723 @default.
- W1991175586 cites W2077089293 @default.
- W1991175586 cites W2083098067 @default.
- W1991175586 cites W2084087648 @default.
- W1991175586 cites W2099948919 @default.
- W1991175586 cites W2152997319 @default.
- W1991175586 cites W2411693876 @default.
- W1991175586 cites W2418363917 @default.
- W1991175586 cites W2432828016 @default.
- W1991175586 cites W33455160 @default.
- W1991175586 doi "https://doi.org/10.1016/0026-0495(95)90307-0" @default.
- W1991175586 hasPublicationYear "1995" @default.
- W1991175586 type Work @default.
- W1991175586 sameAs 1991175586 @default.
- W1991175586 citedByCount "1" @default.
- W1991175586 crossrefType "journal-article" @default.
- W1991175586 hasAuthorship W1991175586A5066985276 @default.
- W1991175586 hasConcept C126322002 @default.
- W1991175586 hasConcept C141071460 @default.
- W1991175586 hasConcept C2776297358 @default.
- W1991175586 hasConcept C2777433750 @default.
- W1991175586 hasConcept C2778886798 @default.
- W1991175586 hasConcept C2781025020 @default.
- W1991175586 hasConcept C2984496839 @default.
- W1991175586 hasConcept C509974204 @default.
- W1991175586 hasConcept C71315377 @default.
- W1991175586 hasConcept C71924100 @default.
- W1991175586 hasConcept C90924648 @default.
- W1991175586 hasConceptScore W1991175586C126322002 @default.
- W1991175586 hasConceptScore W1991175586C141071460 @default.
- W1991175586 hasConceptScore W1991175586C2776297358 @default.
- W1991175586 hasConceptScore W1991175586C2777433750 @default.
- W1991175586 hasConceptScore W1991175586C2778886798 @default.
- W1991175586 hasConceptScore W1991175586C2781025020 @default.
- W1991175586 hasConceptScore W1991175586C2984496839 @default.
- W1991175586 hasConceptScore W1991175586C509974204 @default.
- W1991175586 hasConceptScore W1991175586C71315377 @default.
- W1991175586 hasConceptScore W1991175586C71924100 @default.
- W1991175586 hasConceptScore W1991175586C90924648 @default.
- W1991175586 hasLocation W19911755861 @default.
- W1991175586 hasOpenAccess W1991175586 @default.
- W1991175586 hasPrimaryLocation W19911755861 @default.
- W1991175586 hasRelatedWork W180000229 @default.
- W1991175586 hasRelatedWork W1966058349 @default.
- W1991175586 hasRelatedWork W1973298598 @default.
- W1991175586 hasRelatedWork W1997490255 @default.
- W1991175586 hasRelatedWork W1997504907 @default.
- W1991175586 hasRelatedWork W2084751356 @default.
- W1991175586 hasRelatedWork W2088657084 @default.
- W1991175586 hasRelatedWork W2137923662 @default.
- W1991175586 hasRelatedWork W2152143098 @default.
- W1991175586 hasRelatedWork W2290282553 @default.
- W1991175586 hasRelatedWork W2337780107 @default.
- W1991175586 hasRelatedWork W2338557649 @default.
- W1991175586 hasRelatedWork W2407670339 @default.
- W1991175586 hasRelatedWork W2464152651 @default.
- W1991175586 hasRelatedWork W2742999895 @default.
- W1991175586 hasRelatedWork W3021442203 @default.
- W1991175586 hasRelatedWork W3029454595 @default.
- W1991175586 hasRelatedWork W3035615424 @default.
- W1991175586 hasRelatedWork W3096419718 @default.
- W1991175586 hasRelatedWork W3156105916 @default.
- W1991175586 isParatext "false" @default.
- W1991175586 isRetracted "false" @default.
- W1991175586 magId "1991175586" @default.
- W1991175586 workType "article" @default.