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• W1991200346 abstract "Introduction . PET imaging is a useful clinical tool for studying tumor progression and treatment effects. Conventional 18 F-FDG-PET imaging is of limited usefulness for imaging Glioblastoma Multiforme (GBM) due to high levels of glucose uptake by normal brain and the resultant signal-to-noise intensity. 18 F-Fluorothymidine (FLT) in contrast has shown promise for imaging GBM, as thymidine is taken up preferentially by proliferating cells. These studies were undertaken to investigate the effectiveness of 18 F-FLT-PET in a GBM mouse model, especially after radiation therapy (RT), and its correlation with useful biomarkers, including proliferation and DNA damage. Methods . Nude/athymic mice with human GBM orthografts were assessed by microPET imaging with 18 F-FDG and 18 F-FLT. Patterns of tumor PET imaging were then compared to immunohistochemistry and immunofluorescence for markers of proliferation (Ki-67), DNA damage and repair (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mi>γ</mml:mi></mml:mrow></mml:math>H2AX), hypoxia (HIF-1<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:mi>α</mml:mi></mml:mrow></mml:math>), and angiogenesis (VEGF). Results . We confirmed that 18 F-FLT-PET uptake is limited in healthy mice but enhanced in the intracranial tumors. Our data further demonstrate that 18 F-FLT-PET imaging usefully reflects the inhibition of tumor by RT and correlates with changes in biomarker expression. Conclusions . 18 F-FLT-PET imaging is a promising tumor imaging modality for GBM, including assessing RT effects and biologically relevant biomarkers." @default.
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• W1991200346 date "2013-01-01" @default.
• W1991200346 modified "2023-10-17" @default.
• W1991200346 title "18F-Fluorothymidine-Pet Imaging of Glioblastoma Multiforme: Effects of Radiation Therapy on Radiotracer Uptake and Molecular Biomarker Patterns" @default.
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• W1991200346 doi "https://doi.org/10.1155/2013/796029" @default.
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