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• W1991208631 abstract "The injection of a suspension of a polyacrylamide gel (bio gel) into the dorsal subcutaneous area of mice induced an inflammatory reaction and the migration of neutrophils towards the inflamed site. The intravenous administration of anti‐inflammatory drugs (dexamethasone, indomethacin and lysine‐acetylsalicylate) to Polyacrylamide gel‐treated mice inhibited the accumulation of neutrophils in the inflamed site. A similar administration of a 36 K mouse lipocortin, induced a strong dose‐dependent inhibition of neutrophil accumulation in the inflamed site. Dexamethasone and lipocortin inhibited the production of eicosanoids, prostaglandin E 2 (PGE 2 ) and leukotriene B 4 (LTB 4 ) in the inflamed site of Polyacrylamide gel‐treated mice. Lipocortin impaired both phospholipase A 2 (PLA 2 ) activity and chemotaxis of isolated inflammatory neutrophils. The present studies show an in vivo anti‐inflammatory effect of lipocortin similar to that of glucocorticosteroids. In agreement with recent data on the extracellular effects of various lipocortins, these results might implicate lipocortin(s) in the anti‐inflammatory effects of glucocorticosteroids." @default.
• W1991208631 created "2016-06-24" @default.
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• W1991208631 date "1989-08-01" @default.
• W1991208631 modified "2023-10-17" @default.
• W1991208631 title "A purified lipocortin shares the anti-inflammatory effect of glucocorticosteroids in vivo in mice" @default.
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• W1991208631 doi "https://doi.org/10.1111/j.1476-5381.1989.tb12561.x" @default.
• W1991208631 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1854626" @default.
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