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- W1991214829 endingPage "e41849" @default.
- W1991214829 startingPage "e41849" @default.
- W1991214829 abstract "Marek's disease (MD) is a lymphoproliferative disease in chicken induced by Marek's disease virus (MDV). Although studies have focused on the genetic differences between the resistant and susceptible chicken, less is known about the role of epigenetic factors in MD. In this study, genome-wide histone modifications in the non-MHC-associated resistant and susceptible chicken lines were examined. We found that tri-methylation at histone H3 Lys4 (H3K4me3) enrichment is positively correlated with the expression of protein coding genes as well as microRNA (miRNA) genes, whereas tri-methylation at histone H3 Lys27 (H3K27me3) exhibits a negative correlation. By identifying line-specific histone modifications in MDV infection, we found unique H3K4me3 islands in the resistant chicken activated genes, which are related to immune response and cell adhesion. Interestingly, we also found some miRNAs from unique H3K27me3 patterns in the susceptible chickens that targeted genes involved in 5-hydroxytryptamine (5-HT)-receptor and adrenergic receptor pathways. In conclusion, dynamic line-specific histone modifications in response to MDV infection suggested that intrinsic epigenetic mechanisms may play a role in MD-resistance and -susceptibility." @default.
- W1991214829 created "2016-06-24" @default.
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- W1991214829 date "2012-07-26" @default.
- W1991214829 modified "2023-10-18" @default.
- W1991214829 title "Histone Methylation Analysis and Pathway Predictions in Chickens after MDV Infection" @default.
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- W1991214829 doi "https://doi.org/10.1371/journal.pone.0041849" @default.
- W1991214829 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3406056" @default.
- W1991214829 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22848633" @default.
- W1991214829 hasPublicationYear "2012" @default.
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