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• W1991222457 abstract "Rad17-Mec3-Ddc1 forms a proliferating cell nuclear antigen-like complex that is required for the DNA damage response in <i>Saccharomyces cerevisiae</i> and acts at an early step of the signal transduction cascade activated by DNA lesions. We used the <i>mec3-dn</i> allele, which causes a dominant negative checkpoint defect in G₁ but not in G₂, to test the stability of the complex <i>in vivo</i> and to correlate its assembly and disassembly with the mechanisms controlling checkpoint activation. Under physiological conditions, the mutant complex is formed both in G₁ and G₂, although the mutant phenotype is detectable only in G₁, suggesting that is not the presence of the mutant complex <i>per se</i> to cause a checkpoint defect. Our data indicate that the Rad17-Mec3-Ddc1 complex is very stable, and it takes several hours to replace Mec3 with Mec3-dn within a wild type complex. On the other hand, the mutant complex is rapidly assembled when starting from a condition where the complex is not pre-assembled, indicating that the critical factor for the substitution is the disassembly step rather than complex formation. Moreover, the kinetics of mutant complex assembly, starting from conditions in which the wild type form is present, parallels the kinetics of checkpoint inactivation, suggesting that the complex acts in a stoichiometric way, rather than catalytically." @default.
• W1991222457 created "2016-06-24" @default.
• W1991222457 creator A5043484634 @default.
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• W1991222457 date "2003-06-01" @default.
• W1991222457 modified "2023-10-16" @default.
• W1991222457 title "Correlation between Checkpoint Activation and in Vivo Assembly of the Yeast Checkpoint Complex Rad17-Mec3-Ddc1" @default.
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• W1991222457 doi "https://doi.org/10.1074/jbc.m301260200" @default.
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• W1991222457 hasPublicationYear "2003" @default.
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