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- W1991231518 abstract "Prostaglandin E2 (PGE2) acts as a potent stimulator of bone resorption. We examined PGE2-induced bone resorption using mice lacking each subtype (EP1, EP2, EP3 and EP4) of PGE receptor and identified the PGE receptor subtype(s) mediating PGE2 action. In calvarial culture from EP1-, EP2-, and EP3- knockout mice, PGE2 stimulated bone resorption to a similar extent to that found in calvaria from the wild-type mice. On the other hand, a marked reduction in bone resorption in response to PGE2 was found in the calvarial culture from EP4-knockout/mice. DbcAMP greatly stimulated bone resorption similarly in both wild-type and EP4-knockout mice. In mouse calvarial cultures, EP4-agonist markedly stimulated bone resorption, but its maximal stimulation was less than that induced by PGE2. EP2-agonist also stimulated bone resorption, but only slightly, EP1- and EP3-agonists did not stimulate it at all. These findings suggest that PGE2 stimulates bone resorption by a mechanism involving cAMP, which is mediated mainly by EP4 and partially by EP2." @default.
- W1991231518 created "2016-06-24" @default.
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- W1991231518 date "2001-01-01" @default.
- W1991231518 modified "2023-09-25" @default.
- W1991231518 title "The Prostanoid Receptors: Molecular Approaches to Drug Development. Role of EP4 receptor in bone resorption induced by PGE." @default.
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- W1991231518 doi "https://doi.org/10.1254/fpj.117.293" @default.
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