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- W1991231618 abstract "Our group has previously shown that excess glucose induces a pro-inflammatory and anti-angiogenic milieu in first trimester trophoblasts (TBs). These placental perturbations may contribute to the increased risk of preeclampsia in pregnancies with diabetes. N-acetylcysteine (NAC) is a potent hydroxyl radical scavenger that imparts anti-inflammatory actions in multiple disease models, but its effects on TBs have not been elucidated. The objective of this study is to determine the ability of NAC to reverse the glucose-induced cytokine and angiogenic factor effects of first trimester TBs. The human first trimester extravillous TBs cell line (Sw-71) was cultured with media containing glucose [5 mM, normoglycemia (NG); 10 mM, borderline hyperglycemia (HG); or 25 mM, HG), and co-treated with NAC (0.625 mM or 0.8 mM). After 72 hrs, supernatants were collected and assayed for IL-6, sFlt-1, and VEGF by ELISA. Statistical significance (p<0.05) was determined using one-way ANOVA with Bonferroni correction for multiple comparisons. In response to excess glucose, IL-6 and sFlt-1 secretion increased, as previously reported. Increased secretion of the pro-inflammatory IL-6 was not reversed by NAC, and NAC further increased secretion of IL-6 at the high dose (Figure 1, *p<0.05). Increased secretion of the antiangiogenic factor sFlt-1 was also not reversed by NAC (Figure 2, *p<0.05). VEGF secretion did not change with hyperglycemia and was not altered by NAC (Figure 3, *p<0.05). Although NAC has been shown to reverse inflammation in multiple disease models, the free radical scavenger does not appear to be able to reverse the potent inflammation and anti-angiogenic milieu induced by excess glucose in first trimester TBs." @default.
- W1991231618 created "2016-06-24" @default.
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- W1991231618 date "2014-01-01" @default.
- W1991231618 modified "2023-10-14" @default.
- W1991231618 title "780: N-acetylcysteine (NAC) does not reverse pro-inflammatory and anti-angiogenic effects of excess glucose on trophoblasts" @default.
- W1991231618 doi "https://doi.org/10.1016/j.ajog.2013.10.813" @default.
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