Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991231925> ?p ?o ?g. }
- W1991231925 endingPage "945" @default.
- W1991231925 startingPage "931" @default.
- W1991231925 abstract "Loss-of-function mutations in the parkin gene, which encodes an E3 ubiquitin ligase, are the major cause of early-onset Parkinson's disease (PD). Decreases in parkin activity may also contribute to neurodegeneration in sporadic forms of PD. Here, we show that bcl-2-associated athanogene 5 (BAG5), a BAG family member, directly interacts with parkin and the chaperone Hsp70. Within this complex, BAG5 inhibits both parkin E3 ubiquitin ligase activity and Hsp70-mediated refolding of misfolded proteins. BAG5 enhances parkin sequestration within protein aggregates and mitigates parkin-dependent preservation of proteasome function. Finally, BAG5 enhances dopamine neuron death in an in vivo model of PD, whereas a mutant that inhibits BAG5 activity attenuates dopaminergic neurodegeneration. This contrasts with the antideath functions ascribed to BAG family members and suggests a potential role for BAG5 in promoting neurodegeneration in sporadic PD through its functional interactions with parkin and Hsp70." @default.
- W1991231925 created "2016-06-24" @default.
- W1991231925 creator A5022984404 @default.
- W1991231925 creator A5032473070 @default.
- W1991231925 creator A5033165479 @default.
- W1991231925 creator A5036111826 @default.
- W1991231925 creator A5040887607 @default.
- W1991231925 creator A5044640424 @default.
- W1991231925 creator A5061833849 @default.
- W1991231925 creator A5063481044 @default.
- W1991231925 creator A5071124477 @default.
- W1991231925 creator A5083838944 @default.
- W1991231925 date "2004-12-01" @default.
- W1991231925 modified "2023-09-25" @default.
- W1991231925 title "BAG5 Inhibits Parkin and Enhances Dopaminergic Neuron Degeneration" @default.
- W1991231925 cites W1507128123 @default.
- W1991231925 cites W1527671059 @default.
- W1991231925 cites W1529474377 @default.
- W1991231925 cites W1541950149 @default.
- W1991231925 cites W1550876205 @default.
- W1991231925 cites W1559661072 @default.
- W1991231925 cites W1606037334 @default.
- W1991231925 cites W1877873625 @default.
- W1991231925 cites W1879327185 @default.
- W1991231925 cites W1901873593 @default.
- W1991231925 cites W1971340048 @default.
- W1991231925 cites W1972939055 @default.
- W1991231925 cites W1974208595 @default.
- W1991231925 cites W1986188355 @default.
- W1991231925 cites W1987956070 @default.
- W1991231925 cites W1993218631 @default.
- W1991231925 cites W1997369314 @default.
- W1991231925 cites W2011603170 @default.
- W1991231925 cites W2024891592 @default.
- W1991231925 cites W2025116212 @default.
- W1991231925 cites W2025270890 @default.
- W1991231925 cites W2026314272 @default.
- W1991231925 cites W2032817175 @default.
- W1991231925 cites W2035531816 @default.
- W1991231925 cites W2039824115 @default.
- W1991231925 cites W2040272587 @default.
- W1991231925 cites W2042208155 @default.
- W1991231925 cites W2045597126 @default.
- W1991231925 cites W2047211900 @default.
- W1991231925 cites W2068806054 @default.
- W1991231925 cites W2071960241 @default.
- W1991231925 cites W2073687064 @default.
- W1991231925 cites W2073991273 @default.
- W1991231925 cites W2076344205 @default.
- W1991231925 cites W2080173749 @default.
- W1991231925 cites W2080889643 @default.
- W1991231925 cites W2083081815 @default.
- W1991231925 cites W2084228067 @default.
- W1991231925 cites W2091586455 @default.
- W1991231925 cites W2091693910 @default.
- W1991231925 cites W2094478098 @default.
- W1991231925 cites W2105970121 @default.
- W1991231925 cites W2110780830 @default.
- W1991231925 cites W2114881821 @default.
- W1991231925 cites W2115988944 @default.
- W1991231925 cites W2116414519 @default.
- W1991231925 cites W2117743221 @default.
- W1991231925 cites W2120706471 @default.
- W1991231925 cites W2130565053 @default.
- W1991231925 cites W2132620387 @default.
- W1991231925 cites W2133301860 @default.
- W1991231925 cites W2133550059 @default.
- W1991231925 cites W2137952321 @default.
- W1991231925 cites W2142780460 @default.
- W1991231925 cites W2145669564 @default.
- W1991231925 cites W2145683656 @default.
- W1991231925 cites W2148869194 @default.
- W1991231925 cites W2153747430 @default.
- W1991231925 cites W2154445158 @default.
- W1991231925 cites W2157295566 @default.
- W1991231925 cites W2166987747 @default.
- W1991231925 cites W2170594193 @default.
- W1991231925 cites W2171114341 @default.
- W1991231925 cites W2792448780 @default.
- W1991231925 cites W37005 @default.
- W1991231925 cites W4297062289 @default.
- W1991231925 cites W62603772 @default.
- W1991231925 doi "https://doi.org/10.1016/j.neuron.2004.11.026" @default.
- W1991231925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15603737" @default.
- W1991231925 hasPublicationYear "2004" @default.
- W1991231925 type Work @default.
- W1991231925 sameAs 1991231925 @default.
- W1991231925 citedByCount "179" @default.
- W1991231925 countsByYear W19912319252012 @default.
- W1991231925 countsByYear W19912319252013 @default.
- W1991231925 countsByYear W19912319252014 @default.
- W1991231925 countsByYear W19912319252015 @default.
- W1991231925 countsByYear W19912319252016 @default.
- W1991231925 countsByYear W19912319252017 @default.
- W1991231925 countsByYear W19912319252018 @default.
- W1991231925 countsByYear W19912319252019 @default.
- W1991231925 countsByYear W19912319252020 @default.
- W1991231925 countsByYear W19912319252021 @default.