Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991232080> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1991232080 endingPage "1372" @default.
- W1991232080 startingPage "1365" @default.
- W1991232080 abstract "Monoclonal antibodies (MAbs) directed against epitopes on the Cγ1, Cγ2, Cγ3 and Cγ2-Cγ3 interface regions of human IgG were used to attempt to localize the monocyte Fc receptor (FcR) binding site. The MAbs have been assayed for their capacity to inhibit the interaction between 125I-labelled IgG (125I-IgG) and human monocytes or human histiocytic lymphoma U937 cells. Two MAbs specific for epitopes on the N-terminal region of the Cγ2 domain, and one MAb recognizing an epitope in the Cγ2-Cγ3 inter-domain region inhibited binding of 125I-IgG to monocyte FcRs. The remaining MAbs, against a C-terminal Cγ3 domain epitope, another Cγ2/Cγ3 region epitope and the Glm(f) allotope on the Cγl domain did not inhibit the interaction. The capacity of the MAbs to bind to their respective epitopes on cell surface FcR-bound IgG was also studied, using indirect radiobinding and immunofluorescence assays. All of the MAbs, except those with Cγ2 domain specificities, were able to detect FcR-bound IgG under these conditions. The results confirm the role of the Cγ2 domain in the interaction of IgG with monocytes and demonstrate that epitopes in the Cγ3 and Cγ2-Cγ3 regions are not involved in the binding site." @default.
- W1991232080 created "2016-06-24" @default.
- W1991232080 creator A5020989649 @default.
- W1991232080 creator A5058546353 @default.
- W1991232080 creator A5059311261 @default.
- W1991232080 creator A5086098057 @default.
- W1991232080 date "1986-12-01" @default.
- W1991232080 modified "2023-09-24" @default.
- W1991232080 title "The use of anti-IgG monoclonal antibodies in mapping the monocyte receptor site on IgG" @default.
- W1991232080 cites W111759003 @default.
- W1991232080 cites W1511067427 @default.
- W1991232080 cites W1579031049 @default.
- W1991232080 cites W1601423739 @default.
- W1991232080 cites W1608668899 @default.
- W1991232080 cites W1655785034 @default.
- W1991232080 cites W1893865091 @default.
- W1991232080 cites W1964522754 @default.
- W1991232080 cites W1966290907 @default.
- W1991232080 cites W1984001284 @default.
- W1991232080 cites W1989924708 @default.
- W1991232080 cites W1997811409 @default.
- W1991232080 cites W2009811622 @default.
- W1991232080 cites W2018552607 @default.
- W1991232080 cites W2042482831 @default.
- W1991232080 cites W2045193638 @default.
- W1991232080 cites W2066683383 @default.
- W1991232080 cites W2073235310 @default.
- W1991232080 cites W2075619296 @default.
- W1991232080 cites W2092562610 @default.
- W1991232080 cites W2128285319 @default.
- W1991232080 cites W2309779194 @default.
- W1991232080 doi "https://doi.org/10.1016/0161-5890(86)90022-2" @default.
- W1991232080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2434846" @default.
- W1991232080 hasPublicationYear "1986" @default.
- W1991232080 type Work @default.
- W1991232080 sameAs 1991232080 @default.
- W1991232080 citedByCount "36" @default.
- W1991232080 countsByYear W19912320802013 @default.
- W1991232080 countsByYear W19912320802017 @default.
- W1991232080 countsByYear W19912320802021 @default.
- W1991232080 crossrefType "journal-article" @default.
- W1991232080 hasAuthorship W1991232080A5020989649 @default.
- W1991232080 hasAuthorship W1991232080A5058546353 @default.
- W1991232080 hasAuthorship W1991232080A5059311261 @default.
- W1991232080 hasAuthorship W1991232080A5086098057 @default.
- W1991232080 hasConcept C153911025 @default.
- W1991232080 hasConcept C159654299 @default.
- W1991232080 hasConcept C185592680 @default.
- W1991232080 hasConcept C195616568 @default.
- W1991232080 hasConcept C203014093 @default.
- W1991232080 hasConcept C2781184567 @default.
- W1991232080 hasConcept C2781241564 @default.
- W1991232080 hasConcept C542903549 @default.
- W1991232080 hasConcept C78598654 @default.
- W1991232080 hasConcept C86803240 @default.
- W1991232080 hasConceptScore W1991232080C153911025 @default.
- W1991232080 hasConceptScore W1991232080C159654299 @default.
- W1991232080 hasConceptScore W1991232080C185592680 @default.
- W1991232080 hasConceptScore W1991232080C195616568 @default.
- W1991232080 hasConceptScore W1991232080C203014093 @default.
- W1991232080 hasConceptScore W1991232080C2781184567 @default.
- W1991232080 hasConceptScore W1991232080C2781241564 @default.
- W1991232080 hasConceptScore W1991232080C542903549 @default.
- W1991232080 hasConceptScore W1991232080C78598654 @default.
- W1991232080 hasConceptScore W1991232080C86803240 @default.
- W1991232080 hasIssue "12" @default.
- W1991232080 hasLocation W19912320801 @default.
- W1991232080 hasLocation W19912320802 @default.
- W1991232080 hasOpenAccess W1991232080 @default.
- W1991232080 hasPrimaryLocation W19912320801 @default.
- W1991232080 hasRelatedWork W1540778049 @default.
- W1991232080 hasRelatedWork W1998113631 @default.
- W1991232080 hasRelatedWork W2003373552 @default.
- W1991232080 hasRelatedWork W2011407993 @default.
- W1991232080 hasRelatedWork W2062700146 @default.
- W1991232080 hasRelatedWork W2182360597 @default.
- W1991232080 hasRelatedWork W2471846512 @default.
- W1991232080 hasRelatedWork W3096915742 @default.
- W1991232080 hasRelatedWork W3105097885 @default.
- W1991232080 hasRelatedWork W4241031629 @default.
- W1991232080 hasVolume "23" @default.
- W1991232080 isParatext "false" @default.
- W1991232080 isRetracted "false" @default.
- W1991232080 magId "1991232080" @default.
- W1991232080 workType "article" @default.