FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991232794> ?p ?o ?g. }

• W1991232794 abstract "Non-heart-beating donors (NHBDs) are considered potential sources of transplant organs in an effort to alleviate the problem of donor shortage in clinical liver transplantation. We investigated the possibility of pharmacologic protection of hepatic allograft function from NHBDs without donor pretreatment.Orthotopic liver transplantation was performed using pigs. In donors, cardiac arrest was induced by stopping the respirator. Forty-five minutes after cessation of the respirator, the liver was flushed with cold lactated Ringer's solution including heparin and with the University of Wisconsin (UW) solution, and then preserved for 8 hr at 4 degrees C in the UW solution. The pigs were divided into two groups: a control group and a treated group. In the treated group, an endothelin antagonist TAK-044 was added to the UW solutions (10 mg/L), and TAK-044 (10 mg/kg body weight) and a platelet activating factor antagonist E5880 (0.3 mg/kg body weight) were also administered to the recipients.TAK-044 and E5880 treatment significantly increased the 7-day survival rate of the recipients (100% vs. 17%, P<0.05). In the treated group, portal venous pressure immediately after reperfusion of the graft was significantly lower than in the control group, and postoperative increase in serum concentrations of glutamic oxaloacetic transaminase and total bilirubin was attenuated. Moreover, the energy charge and adenosine triphosphate concentration of the liver were rapidly restored after reperfusion.Pharmacologic modulation with TAK-044 and E5880 avoiding donor pretreatment can improve the viability of hepatic allografts procured from NHBDs." @default.
• W1991232794 created "2016-06-24" @default.
• W1991232794 creator A5001938499 @default.
• W1991232794 creator A5021360652 @default.
• W1991232794 creator A5038228073 @default.
• W1991232794 creator A5039763317 @default.
• W1991232794 creator A5047894538 @default.
• W1991232794 creator A5053290611 @default.
• W1991232794 creator A5072488038 @default.
• W1991232794 creator A5079510389 @default.
• W1991232794 creator A5082962036 @default.
• W1991232794 creator A5091877732 @default.
• W1991232794 date "2000-10-01" @default.
• W1991232794 modified "2023-09-22" @default.
• W1991232794 title "PHARMACOLOGIC GRAFT PROTECTION WITHOUT DONOR PRETREATMENT IN LIVER TRANSPLANTATION FROM NON-HEART-BEATING DONORS1" @default.
• W1991232794 cites W1971328499 @default.
• W1991232794 cites W1980968806 @default.
• W1991232794 cites W1985509496 @default.
• W1991232794 cites W1986756802 @default.
• W1991232794 cites W1996131549 @default.
• W1991232794 cites W2001639220 @default.
• W1991232794 cites W2006687037 @default.
• W1991232794 cites W2010844371 @default.
• W1991232794 cites W2014608270 @default.
• W1991232794 cites W2024884563 @default.
• W1991232794 cites W2028479043 @default.
• W1991232794 cites W2038271519 @default.
• W1991232794 cites W2041816954 @default.
• W1991232794 cites W2044682314 @default.
• W1991232794 cites W2061437240 @default.
• W1991232794 cites W2065892808 @default.
• W1991232794 cites W2070218196 @default.
• W1991232794 cites W2095105800 @default.
• W1991232794 cites W2098300843 @default.
• W1991232794 cites W2140673033 @default.
• W1991232794 cites W2143827991 @default.
• W1991232794 cites W2144501970 @default.
• W1991232794 cites W2144936958 @default.
• W1991232794 cites W2144987204 @default.
• W1991232794 cites W2408673183 @default.
• W1991232794 cites W2474891563 @default.
• W1991232794 cites W3143099449 @default.
• W1991232794 doi "https://doi.org/10.1097/00007890-200010150-00006" @default.
• W1991232794 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11045637" @default.
• W1991232794 hasPublicationYear "2000" @default.
• W1991232794 type Work @default.
• W1991232794 sameAs 1991232794 @default.
• W1991232794 citedByCount "12" @default.
• W1991232794 countsByYear W19912327942015 @default.
• W1991232794 countsByYear W19912327942019 @default.
• W1991232794 crossrefType "journal-article" @default.
• W1991232794 hasAuthorship W1991232794A5001938499 @default.
• W1991232794 hasAuthorship W1991232794A5021360652 @default.
• W1991232794 hasAuthorship W1991232794A5038228073 @default.
• W1991232794 hasAuthorship W1991232794A5039763317 @default.
• W1991232794 hasAuthorship W1991232794A5047894538 @default.
• W1991232794 hasAuthorship W1991232794A5053290611 @default.
• W1991232794 hasAuthorship W1991232794A5072488038 @default.
• W1991232794 hasAuthorship W1991232794A5079510389 @default.
• W1991232794 hasAuthorship W1991232794A5082962036 @default.
• W1991232794 hasAuthorship W1991232794A5091877732 @default.
• W1991232794 hasConcept C113278225 @default.
• W1991232794 hasConcept C126322002 @default.
• W1991232794 hasConcept C126894567 @default.
• W1991232794 hasConcept C141071460 @default.
• W1991232794 hasConcept C2779609443 @default.
• W1991232794 hasConcept C2780114680 @default.
• W1991232794 hasConcept C2911091166 @default.
• W1991232794 hasConcept C42219234 @default.
• W1991232794 hasConcept C541997718 @default.
• W1991232794 hasConcept C71924100 @default.
• W1991232794 hasConceptScore W1991232794C113278225 @default.
• W1991232794 hasConceptScore W1991232794C126322002 @default.
• W1991232794 hasConceptScore W1991232794C126894567 @default.
• W1991232794 hasConceptScore W1991232794C141071460 @default.
• W1991232794 hasConceptScore W1991232794C2779609443 @default.
• W1991232794 hasConceptScore W1991232794C2780114680 @default.
• W1991232794 hasConceptScore W1991232794C2911091166 @default.
• W1991232794 hasConceptScore W1991232794C42219234 @default.
• W1991232794 hasConceptScore W1991232794C541997718 @default.
• W1991232794 hasConceptScore W1991232794C71924100 @default.
• W1991232794 hasLocation W19912327941 @default.
• W1991232794 hasLocation W19912327942 @default.
• W1991232794 hasOpenAccess W1991232794 @default.
• W1991232794 hasPrimaryLocation W19912327941 @default.
• W1991232794 hasRelatedWork W1980968806 @default.
• W1991232794 hasRelatedWork W1982599965 @default.
• W1991232794 hasRelatedWork W1993462029 @default.
• W1991232794 hasRelatedWork W2003151317 @default.
• W1991232794 hasRelatedWork W2005523157 @default.
• W1991232794 hasRelatedWork W2026422568 @default.
• W1991232794 hasRelatedWork W2027702624 @default.
• W1991232794 hasRelatedWork W2056270423 @default.
• W1991232794 hasRelatedWork W2061437240 @default.
• W1991232794 hasRelatedWork W2062218007 @default.
• W1991232794 hasRelatedWork W2065892808 @default.
• W1991232794 hasRelatedWork W2070218196 @default.
• W1991232794 hasRelatedWork W2077438414 @default.
• W1991232794 hasRelatedWork W2089988407 @default.
• W1991232794 hasRelatedWork W2090225310 @default.

• next