Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991232823> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W1991232823 endingPage "328" @default.
- W1991232823 startingPage "314" @default.
- W1991232823 abstract "The mAb A6 was produced by immunization of mice with human PHA-stimulated PBMC. Immunoprecipitation studies and staining of cell lines transfected with individual leukocyte common antigen (LCA) isoforms showed that A6 recognizes a unique epitope strongly expressed on the lower MW isoform (p180) of LCA, but also weakly expressed on the p190 isoform coded by exon B and the p205 coded by exons A and B. The epitope recognized by A6 was carbohydrate-dependent in that it was neuraminidase-sensitive, but trypsin-resistant. A6 stained most TCR-αβ+ cells with differential intensities, subdividing them into a bright and dim population, and strongly stained all TCR-γδ+ cells. A6 did not stain CD19+ B cells nor CD56+ NK cells. Anti-CD45 mAb such as UCHL1 recognizing CD45RO have been used to define memory T cells. Depletion of PBMC subsets with A6 or UCHL1 mAb dramatically decreased proliferative responses to the recall antigens anti-CD3 mAb and alloantigen and enhanced their responses to PHA. A6, unlike UCHL1, also depleted alloreactive T cells that affect primary and secondary MLC and CML. Thus, A6 was shown to recognize the lower MW isoforms of LCA which are expressed on functional T cell subsets including memory, activated, and alloreactive T cells." @default.
- W1991232823 created "2016-06-24" @default.
- W1991232823 creator A5013495107 @default.
- W1991232823 creator A5020556945 @default.
- W1991232823 creator A5042060009 @default.
- W1991232823 date "1994-10-01" @default.
- W1991232823 modified "2023-09-26" @default.
- W1991232823 title "A Monoclonal Antibody (A6) Recognizing a Unique Epitope Restricted to CD45RO and RB Isoforms of the Leukocyte Common Antigen Family Identifies Functional T Cell Subsets" @default.
- W1991232823 doi "https://doi.org/10.1006/cimm.1994.1279" @default.
- W1991232823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7522974" @default.
- W1991232823 hasPublicationYear "1994" @default.
- W1991232823 type Work @default.
- W1991232823 sameAs 1991232823 @default.
- W1991232823 citedByCount "18" @default.
- W1991232823 countsByYear W19912328232012 @default.
- W1991232823 countsByYear W19912328232015 @default.
- W1991232823 countsByYear W19912328232017 @default.
- W1991232823 countsByYear W19912328232021 @default.
- W1991232823 countsByYear W19912328232022 @default.
- W1991232823 crossrefType "journal-article" @default.
- W1991232823 hasAuthorship W1991232823A5013495107 @default.
- W1991232823 hasAuthorship W1991232823A5020556945 @default.
- W1991232823 hasAuthorship W1991232823A5042060009 @default.
- W1991232823 hasConcept C104317684 @default.
- W1991232823 hasConcept C147483822 @default.
- W1991232823 hasConcept C153911025 @default.
- W1991232823 hasConcept C159654299 @default.
- W1991232823 hasConcept C195616568 @default.
- W1991232823 hasConcept C203014093 @default.
- W1991232823 hasConcept C2776090121 @default.
- W1991232823 hasConcept C53345823 @default.
- W1991232823 hasConcept C542903549 @default.
- W1991232823 hasConcept C54355233 @default.
- W1991232823 hasConcept C86803240 @default.
- W1991232823 hasConcept C8891405 @default.
- W1991232823 hasConceptScore W1991232823C104317684 @default.
- W1991232823 hasConceptScore W1991232823C147483822 @default.
- W1991232823 hasConceptScore W1991232823C153911025 @default.
- W1991232823 hasConceptScore W1991232823C159654299 @default.
- W1991232823 hasConceptScore W1991232823C195616568 @default.
- W1991232823 hasConceptScore W1991232823C203014093 @default.
- W1991232823 hasConceptScore W1991232823C2776090121 @default.
- W1991232823 hasConceptScore W1991232823C53345823 @default.
- W1991232823 hasConceptScore W1991232823C542903549 @default.
- W1991232823 hasConceptScore W1991232823C54355233 @default.
- W1991232823 hasConceptScore W1991232823C86803240 @default.
- W1991232823 hasConceptScore W1991232823C8891405 @default.
- W1991232823 hasIssue "2" @default.
- W1991232823 hasLocation W19912328231 @default.
- W1991232823 hasLocation W19912328232 @default.
- W1991232823 hasOpenAccess W1991232823 @default.
- W1991232823 hasPrimaryLocation W19912328231 @default.
- W1991232823 hasRelatedWork W1604248381 @default.
- W1991232823 hasRelatedWork W1973692620 @default.
- W1991232823 hasRelatedWork W1989765228 @default.
- W1991232823 hasRelatedWork W1999614011 @default.
- W1991232823 hasRelatedWork W2001280522 @default.
- W1991232823 hasRelatedWork W2041069158 @default.
- W1991232823 hasRelatedWork W2162389703 @default.
- W1991232823 hasRelatedWork W2400620861 @default.
- W1991232823 hasRelatedWork W2408918468 @default.
- W1991232823 hasRelatedWork W4239344034 @default.
- W1991232823 hasVolume "158" @default.
- W1991232823 isParatext "false" @default.
- W1991232823 isRetracted "false" @default.
- W1991232823 magId "1991232823" @default.
- W1991232823 workType "article" @default.