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- W1991235040 abstract "Surfactant replacement therapy for treatment or prevention of the respiratory distress syndrome (RDS) has been studied intensively over the past decade. Randomized controlled trials have demonstrated a reduction in the odds of neonatal death of about 40% and of pulmonary air leaks of 35 to 70% depending upon the type of surfactant used. Prophylaxis or very early treatment is superior to later treatment, especially for the very preterm (< 28 week) infant. Natural (derived from animal lungs) surfactants have a more rapid onset of action than synthetic surfactants and may also provide better long-term benefits, but further comparative trials will be needed to demonstrate this conclusively. Surfactant treatment should not be viewed as a substitute for prenatal steroid therapy to enhance fetal lung maturity; the treatments are synergistic. © 1995 Wiley-Liss, Inc." @default.
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- W1991235040 date "1995-01-01" @default.
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- W1991235040 title "Surfactant replacement therapy" @default.
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- W1991235040 doi "https://doi.org/10.1002/ppul.1950191147" @default.
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